Email this article 
Low molecular weight compound GSB-106 mimics the cellular effects of BDNF after serum deprivation
- Authors: Zainullina L.F.1, Gudasheva T.A.1, Vakhitova Y.V.1, Seredenin S.B.1
-
Affiliations:
- State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
- Issue: Vol 489, No 5 (2019)
- Pages: 521-524
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/18851
- DOI: https://doi.org/10.31857/S0869-56524895521-524
- ID: 18851
Cite item
Full Text
Abstract
The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4-th mimetic GSB‑106 (10-7 М), which is comparable to that of endogenous neurotrophin (10-9 М). The analysis of the cell cycle and S‑phase showed that GSB‑106, like BDNF, induces cell cycle arrest in the G1 phase, diminishes the number of cells in the S‑phase, reduces the number of apoptotic cells and does not stimulate proliferation.
About the authors
L. F. Zainullina
State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
T. A. Gudasheva
State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
Yu. V. Vakhitova
State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Author for correspondence.
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
S. B. Seredenin
State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Academician of the Russian Academy of Medical Sciences
Russian Federation, 8, Baltiyskaya street, Moscow, 125315References
- Lewin G.R., Barde Y.A. // Annu. Rev. Neurosci. 1996. V. 19. P. 289-317.
- Reichardt L.F. // Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2006. V. 361. P. 1545-1564.
- Nagahara A.H., Tuszynski M.H. // Nat. Rev. Drug Discov. 2011. V. 10. № 3. P. 209-219.
- Ochs G., Penn R.D., York M., et al. // Amyotroph. Lateral Scler. Other Motor Neuron. Disord. 2000. V. 1. № 3. P. 201-206.
- Lu B., Nagappan G., Guan X., et al. // Nat. Rev. Neurosci. 2013. V. 14. № 6. P. 401-416.
- Гудашева Т.А., Логвинов И.О., Антипова Т.А., Середенин С.Б. // ДАН. 2013. Т. 451. № 5. С. 577-580.
- Гудашева Т.А., Поварнина П.Ю., Середенин С.Б. // Бюлл. эксперим. биол. мед. 2016. Т. 162. № 10. С. 448-451.
- Середенин С.Б., Воронина Т.А., Гудашева Т.А. и др. // Acta natur. 2013. Т. 5. № 4. С. 116-120.
- Поварнина П.Ю., Гарибова Т.Л., Гудашева Т.А., Середенин С.Б. // Acta natur. 2018. Т. 10. № 3. С. 88-92.
- Середенин С.Б., Гудашева Т.А. // Журн. неврол. и психиат. 2015. Т. 6. С. 63-70.
- Agholme L., Lindstrom T., Kagedal K., et al. // J. Alzheimers Dis. 2010. V. 20. № 4. P. 1069-1082.
- Mosmann T. // J. Immunol. Methods. 1983. V. 65. № 1/2. P. 55-63.
- Koh J.-Y., Gwag B.J., Lobner D., et al. // Science. 1995. V. 268. P. 573-575.
- Hetman M., Kanning K., Cavanaugh J.E., et al. // J. Biol. Chem. 1999. V. 274. № 32. P. 22 569-22 580.
Supplementary files
