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Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on NA+ transport in frog skin
- Authors: Krutetskaya Z.I.1, Melnitskaya A.V.1, Antonov V.G.1, Nozdrachev A.D.1
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Affiliations:
- Saint-Petersburg State University
- Issue: Vol 484, No 5 (2019)
- Pages: 629-632
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12788
- DOI: https://doi.org/10.31857/S0869-56524845629-632
- ID: 12788
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Abstract
Using voltage-clamp technique, the involvement of sigma-1 receptors in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with sigma-1 receptor antagonists – haloperidol or chlorpromazine – attenuates the stimulatory effect of glutoxim on Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in glutoxim effect on Na+transport in frog skin epithelium.
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About the authors
Z. I. Krutetskaya
Saint-Petersburg State University
Author for correspondence.
Email: z.krutetskaya@spbu.ru
Russian Federation, Saint-Petersburg
A. V. Melnitskaya
Saint-Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, Saint-Petersburg
V. G. Antonov
Saint-Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, Saint-Petersburg
A. D. Nozdrachev
Saint-Petersburg State University
Email: z.krutetskaya@spbu.ru
Academician of the RAS
Russian Federation, Saint-PetersburgReferences
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