Kinetics of chemical processes in the human brain. Modeling of the BOLD-signal at f-MRT research

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Abstract

A kinetic model describing the impulse of increasing oxygen in the excited nervous tissue of the human brain in response to an external signal is presented. The model is based on biochemical data and describes experimental data on an impulsed hemodynamic response. The model predicts the dynamic behavior of the process participants, which preceding the oxygen impulse and determining the level of the BOLD-signal.

About the authors

S. D. Varfolomeev

Institute of Biochemical Physics of the Russian Academy of Sciences; Lomonosov Moscow State University

Email: vibykov@mail.ru

Corresponding Member of the Russian Academy of Sciences

Russian Federation, 4, Kosygina street, Moscow, 119991; 1, Leninskie gory, Moscow, 119991

N. A. Semenova

Institute of Biochemical Physics of the Russian Academy of Sciences

Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991

V. I. Bykov

Institute of Biochemical Physics of the Russian Academy of Sciences

Author for correspondence.
Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991

S. B. Tsybenova

Institute of Biochemical Physics of the Russian Academy of Sciences

Email: vibykov@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991

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