Biochemical Indices at Assessment of Traumatic Disease Course in Multiple Fractures of Extremity Bones When Treated by Ilizarov Technique

Abstract


Dynamics of concentration of the products of protein, carbohydrate, lipid and mineral metabolism in serum and daily urine was studied in 60 patients with multiple closed fractures of the extremities treated by Ilizarov technique. In the period of early traumatic disease complications alkaline phosphatase activity, calcium and hydroxyproline excretion, intensity of hypoproteinemia, hypocalcemia, hypocholesterinemia and hypotriglyceridemia increased in proportion to injury severity. Maximum changes in metabolic status during the period of early traumatic disease complications were observed in patients been operated on 2 nd - 3 rd days after injury. At early terms of traumatic disease the criteria for evaluation of multiple injury severity were the following: increase in alkaline phosphatase level, marked hypocalcemia and hypercalciuria. Long-term preservation of hypocalcemia and hypercalciuria on the background of blood urea increase at traumatic disease stages confirms the disturbance of osteoreparation and requires medicamental correction.

About the authors

E. A Kireeva

Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia

Email: ea_tkachuk@mail.ru

M. V Stogov

Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia


D. V Samusenko

Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia


References

  1. Цибин Ю.Н., Гальцева И.В., Рыбаков И.Р. Многофакторная оценка тяжести травматического шока в условиях клиники и ее прикладное значение: Методические рекомендации МЗ РСФСР. Л.; 1981.
  2. Gebhard F., Riepl C., Liener U.C., Kinzl L., Bruckner U.B. Volume replacement in trauma patients within the first 24 h and its impact on the interpretation of biochemical data. Langenbecks Arch. Surg. 2000; 385 (6): 406-11.
  3. Dossett L.A., Redhage L.A., Sawyer R.G., May A.K. Revisiting the validity of APACHE II in the trauma ICU: Improved risk stratification in critically injured adults. Injury. 2009; 40 (9): 993-8.
  4. Le Gall J.R., Lemeshow S., Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA. 1993; 270 (24): 2957-63.
  5. Жуков Ю.Б. Диагностическая и прогностическая роль среднемолекулярных полипептидов при сочетанных повреждениях опорно-двигательной системы и головного мозга. Ортопедия, травматология и протезирование. 1997; 1: 42-6.
  6. Коханов А.В., Белопасов В.В., Метелкина Е.В., Демичев Н.П., Ларионов А.А., Суринков Д.Б. Взаимосвязь уровней сывороточных, острофазовых белков и онкомаркеров с количественной оценкой тяжести травмы и общего состояния пострадавших. Клиническая лабораторная диагностика. 2008; 9: 40a-40.
  7. Лунева С.Н., Ткачук Е.А., Стогов М.В. Биохимические показатели в оценке репаративного остеогенеза у пациентов с различными типами скелетной травмы. Гений ортопедии. 2010; 1: 112-5.
  8. Мамаев В.И. Чрескостный остеосинтез и возможности прогнозирования исходов лечения последствий переломов костей. Вестник травматологии и ортопедии им. Н.Н. Приорова. 2008; 3: 25-30.
  9. Устьянцева И.М. Лабораторная диагностика при политравме. Политравма. 2008; 4: 51-9.
  10. Shabat S., Nyska M., Eintacht S., Lis M., Bogomolni A., Berner Y. et al. Serum leptin level in geriatric patients with hip fractures: possible correlation to biochemical parameters of bone remodeling. Arch. Gerontol. Geriatr. 2009; 48 (2): 250-3.
  11. Weisman S.M., Matkovic V. Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk. Clin. Ther. 2005; 27 (3): 299-308.
  12. Bergman I., Lexley R. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Anal. Chem. 1963; 12: 1961-5.
  13. Селезнев С.А., Багненко С.Ф., Шапота Ю.Б., Курыгина А.А., ред. Травматическая болезнь и ее осложнения. СПб.: Политехника; 2004.
  14. Сидоркина А.Н., Сидоркин В.Г. Биохимические аспекты травматической болезни и ее осложнений. Н. Новгород: ННИИТО; 2007.
  15. Дерябин И.И., Насонкин О.С., ред. Травматическая болезнь. Л.: Медицина; 1987.

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Copyright (c) 2014 Kireeva E.A., Stogov M.V., Samusenko D.V.

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