In Vivo Study of Tricomponent Resorbable Calcium Phosphate Bone Cement Based on Tricalcium Phosphate



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Abstract

Results of experimental morphologic study of tricomponent resorbable calcium phosphate bone cement (CPhC), based on tricalcium phosphate for the filling of defect as a temporary bearing resorbable matrix are presented. Study was performed on soviet chinchilla rabbits weighting 3200-3500 g. The model of critical spongy bone defect was used. At different observation terms (6, 9 and 12 months) gradual substitution of biomaterial with newly formed bone tissue from periphery to the center was observed with complete cement resorption 12 months after surgery. By mechanic characteristics newly formed bone in the defect was stronger than the surrounding trabecular one. It was stated that material possessed hemostatic effect and moderate toxicity. Peripheral bone marrow maintained its cellularity at all terms, gradually filling intertrabecular space of newly formed bone. Achieved data enable to recommend wide used of CPhC for bone defects substitution.

About the authors

National Research Center for Hematology, Moscow, RF Mamonov

Email: vasily-mamonov@yandex.ru

National Research Center for Hematology, Moscow, RF Chemis

National Research Center for Hematology, Moscow, RF Drize

National Research Center for Hematology, Moscow, RF Proskurina

I. I Kryazhkov

Institute of Metallurgy and Material Science named after A.A. Baykov, Moscow, RF

V. S Komlev

Institute of Metallurgy and Material Science named after A.A. Baykov, Moscow, RF

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