Clinical features of disorders which have central sensitivity syndrome in its nature are reviewed in this article. Also clinical features and treatment of fibromyalgia syndrome, irritable bowel syndrome, myofascial pain syndrome, tension-type headache, migraine, interstitial cystitis, primary dysmenorrheal are considered.

Full Text


About the authors

Radyey G Esin

Kazan state medical academy

Email: radyesin@gmail.com
420012, Каzan, Мushtari street 11
department of neurology and manual therapy

Oleg R Esin

Republican clinical hospial №2 HM RT

Каzan, Chekhov street, 1а

Elvira R Mukhametova

Kazan state medical academy

420012, Каzan, Мushtari street 11
department of neurology and manual therapy

Nailya Z Lotfullina

Republican clinical hospial №2 HM RT

Каzan, Chekhov street, 1а


  1. Кукушкин М.Л., Яхно Н.Н. Патофизиологические аспекты невропатической боли // Российский журнал боли. 2012. № 1. С. 19–20
  2. Рачин А.П., Якунин К.А., Демешко А.В. Миофасциальный болевой синдром. М.: ГЭОТАР-Медиа, 2009. 120 с
  3. Яхно Н.Н. Боль: руководство для врачей и студентов. М.: МЕДпресс-информ, 2009. 304 с
  4. Arnold L.D., Bachmann G.A., Rosen R. et al. Vulvodynia: Characteristics and associations with comorbidities and quality of life // Obstet. Gynecol. 2006. № 107. P. 617–624
  5. Bajaj P., Madsen H., Arendt-Nielsen L. A comparison of modality-specific somatosensory changes during menstruation in dysmenorrheic and nondysmenorrheic women // Clin. J. Pain. 2002. № 18. P. 180–190
  6. Banic B., Petersen-Felix S., Anderson O.K. et al. Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury // Pain. 2004. № 107. P. 7–15
  7. Bara-Jimenez W., Aksu M., Graham B. et al. Periodic limb movements in sleep: State-dependent excitability of the spinal cord reflex // Neurology. 2000. № 54. P. 1609–1616
  8. Beers M.H., Porter R. S. The Merck Manual of Diagnosis and Therapy. 18th Edition. John Wiley & Sons Incorporated, 2006. 2991 p
  9. Burstein R., Yarnitsky D., Goor-Aryeh I. et al. An association between migraine and cutaneous allodynia // Ann. Neurol. 2000. № 47. P. 614–624
  10. Chae Y., Kim H.Y., Lee H.J. et al. The alteration of pain sensitivity at disease-specific acupuncture points in premenstrual syndrome // J. Physiol. Sci. 2007. Vol. 57, № 2. P. 115–119
  11. Cook D.B., Lange G., Ciccone D.S. et al. Functional imaging of pain in patients with primary fibromyalgia // J. Rheumatol. 2004. № 31. P. 364–378
  12. Curatolo M., Petersen-Felix S., Arendt-Nielsen L. et al. Central hypersen-sitivity in chronic pain after whiplash injury // Clin. J. Pain. 2001. № 17. P. 306–315
  13. Desmeules J.A., Cedraschi C., Rapiti E. et al. Neurophysiologicevidence for a central sensitization in patients with fibromyalgia // Arthritis Rheum. 2003. № 48. P. 1420–1429
  14. Dworkin S.F., Le Resche L. Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique // J. Craniomadib. Disord. 1992. № 6. P. 301–355
  15. Giamberardino M.A., Berkley K.J., Iezzi S. et al. Pain threshold variations in somatic wall tissues as a function of menstrual cycle,segmental site, and tissue depth in non-dysmenorrheic women, dysmenorrheic women, andomen // Pain. 1997. № 71. P. 187–197
  16. Giesecke J., Reed B.D., Haefner H.K. et al. Quantitative sensory testing in vulvodynia patients and increased peripheral pressure pain sensitivity // Obstet. Gynecol. 2004. № 104. P. 126–133
  17. Hapidou E.G., De Catanzaro D. Sensitivity to cold ressor pain in dysmenorrheic and non-dysmenorrheic women as a function of menstrual cycle phase // Pain. 1988. № 34. P. 77–283
  18. IASP Taxonomy [электронный ресурс]. URL: http://www.iasp-pain.org/Content/NavigationMenu/ GeneralResource Links/ PainDefinitions/default.htm (дата обращения 01.12.2012)
  19. Langemark M., Bach F.W., Jensen T.S. et al. Decreased nociceptive flexion reflex threshold in chronic tension-type headache // Arch. Neurol. 1993. № 50. P. 1061–1064
  20. Maixner W., Fillingim R., Booker D. et al. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain // Pain. 1995. № 63. P. 341–351
  21. McBeth J., Silman A.J., Gupta A. et al. Moderation of psychosocial isk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of widespread musculoskeletal pain: Findings of a population-based prospective cohort study // Arthritis Rheum. 2007. №56. P. 360–371
  22. McDermid A.J., Rollman G.B., McCain G.A. Generalized hypervigilance in fibromyalgia: Evidence of perceptual amplification // Pain. 1996. № 66. P. 133–144
  23. Moog M., Quinter J., Hall T. et al. The late whiplash syndrome: A psychophysical study // Eur. J. Pain. 2002. № 6. P. 283–294
  24. Ness T.J., Powell-Boone T., Cannon R. et al. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis // J. Urol. 2005. № 173. P. 1983–1987
  25. Pinsonneault O., Lefebvre G. Primary Dysmenorrhea Consensus Guideline // SOGC Clinical Practice Guidelines. December. 2005. № 169. P. 1117‒1130
  26. Pukall C.F., Binik Y.M., Khalife S.et al. Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome // Pain. 2002. № 96. P. 163–175
  27. Shaver J.L., Wilburn J., Robinson F.P. et al. Womens’s health issues with fibromyalgia syndrome // J. Womens Health. 2006. № 15. P. 1035–1045
  28. Simons D.G. New views of myofascial trigger points: etiology and diagnosis // Arch. Phys. Med. Rehabil. 2008. Vol. 89, № 1. P. 157‒159
  29. Staud R., Vierck C.J., Cannon R.L. et al. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome // Pain. 2001. № 91. P. 165–175
  30. Stedman’s Medical Dictionary 28th Ed. Lippincott Williams & Wilkins, 2006. P.485
  31. Stiasny-Kolster K., Magerl W., Oertel W.H. et al. Staticmechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome // Brain. 2004. № 127. P. 773–782
  32. The International Classification of Headache Disorders 2nd Edition // Cephalalgia. 2004. Vol. 24, suppl. 1. P. 1–160
  33. Trimble K.C., Farouk R., Pryde A. et al. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity // Dig. Dis. Sci. 1995. № 40. P. 1607–1613
  34. Weissman-Fogel I., Sprecher E., Granovsky Y. et al. Repeated noxious stimulation of the skin enhances cutaneous perception of migraine patients in-between attacks: Clinical evidence for cutaneous sub-threshold increase in membrane excitability of central trigeminovascular neurons // Pain. 2003. № 104. P. 693–700
  35. Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity // Nature. 1983. Vol. 306, № 5944. P. 686–688
  36. Yunus M.B. Central sensitivity syndromes: A unified concept for fibromyalgia and other similar maladies // J. Indian Rheum Assoc. 2000. №8. P. 27–33
  37. Yunus M.B. Fibromyalgia and overlapping disorders: A unifying concept of central sensitivity syndromes // Semin. Arthritis Rheum. 2007. Vol. 36, №6. P. 339‒356
  38. Yunus M.B. The Prevalence of Fibromyalgia in Other Chronic Pain Conditions // Pain Res. Treat. 2012. Vol. 2012, Article ID 584573. 8 p



Abstract - 85


Article Metrics

Metrics Loading ...




  • There are currently no refbacks.

Copyright (c) 2013 Esin R.G., Esin O.R., Mukhametova E.R., Lotfullina N.Z.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies