ACTIVITY OF FREE-RADICAL OXIDATION AT SMALL CHILDREN WITH SPASTIC FORMS OF CHILDREN’S CEREBRAL PARALYSIS AT EARLY RESIDUAL STAGE

Abstract


The activity of free-radical oxidation and expressiveness of clinical manifestation of disease (severity level) in children with spastic forms of children’s cerebral paralysis have been studied. It has been proved that in children with spastic diplegia of children’s cerebral paralysis and double hemiplegia with pathological changes of periventricular area the process of free-radical oxidation proceeds actively - the level of antiradical protection enzymes has been increased as well as products of lipid peroxidation. There was revealed a correlation of activity of oxidation processes and severity of clinical manifestations of children’s cerebral paralysis. It was established that a severe degree of the disease proceeds in the background of high-active peroxidation, especially of processes of lipid peroxidation.

About the authors

Dina D Gajnetdinova

Kazan State Medical University

420012 Каzan, Butlerov Street 49
department of neurology, neurosurgery and medical genetics

Dina V Ayzatulina

Kazan State Medical University

Email: dina34@rambler.ru
420012 Каzan, Butlerov Street 49
department of neurology, neurosurgery and medical genetics

References

  1. Гайнетдинова Д.Д. Айзатулина Д.В., Валеева И.Х., Юсупова Э.Ф. Патогенетические механизмы формирования нестабильности генома у детей с перивентрикулярной лейкомаляцией с исходом в детский церебральный паралич // Журнал неврологии и психиатрии им. С.С. Корсакова. 2011. Т.111, №1. С. 74-77
  2. Дубинина Е.Е. Продукты метаболизма кислорода в функциональной активности клеток (жизнь и смерть, созидание и разрушение). Физиологические и клинико-биохимические аспекты. CПб: Медицинская пресса, 2006. 400 с
  3. Методические рекомендации Минздрава СССР “Организация центров воспитания детей“. М., 1990. 24 с
  4. Петрухин А.С. Созаева Н.С. Факторы риска и ранние проявления отдельных форм детского церебрального паралича в различном гестационном возрасте // Казанский медицинский журнал. 2010. Том 91, № 2. С. 180-186
  5. Семенов А.С., Скальный А.В. Иммунопатологические и патохимические аспекты патогенеза перинатального поражения мозга. СПб: Наука, 2009. 368 с
  6. Скворцов И.А. Неврология развития: руководство для врачей. М.: Литтерра, 2008. 544 с
  7. EI-Dib M. Massaro AN., Bulas D., Aly H. Neuroimaging and neurodevelopmental outcome of premature infants // Am. J. Perinatol. 2010. Vol. 27, №. 10. P. 803-818
  8. Fatemi A. Wilson M.A., Johnston M.V. Hypoxic-ishemic encephalopathy in the term infant // Clin. Perinatol. 2009. Vol. 36, № 4. P. 835-858
  9. Morrison J. Preterm Birth - Mother and Child. USA: InTech, 2012. 368p
  10. Msall M.E. Limperopoulos C., Park J.J. Neuroimaging and cerebral palsy in children. // Minerva Pediatr. 2009. Vol.61, № 4. P. 415-424

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