GLYCINE IMPORTANCE IN ACUTE ISCHEMIC STROKE THERAPY



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Abstract

There was shown the prevalence of vascular diseases, including acute cerebrovascular events, reasons of such disorders being multiple systemic changes of neuron metabolism. The correction of imbalance of excitatory and inhibitory neurotransmitter systems is one of the most promising methods of neuroprotection. Much attention is paid to the role of an inhibitory neurotransmitter glycine in the mechanisms of acute cerebral ischemia. Positive effects of glycine on neuronal mitochondrial metabolism have been observed under hypoxic (anoxic) conditions. It was also shown a reduction of events which had been induced by glutamate concentration excess. Along with the effect of direct vasodilation of glycine on arterioles of different tissues it enables to consider glycine as a neuroprotective compound i.e. the medicines which protect against ischemic cascade in therapeutic window.

About the authors

Yaroslav R Nartsissov

Institute of Cytochemistry and Molecular Pharmacology

115404, Moscow, 6th Radialnaya str., 24/14

Elena V Sheshegova

Institute of Cytochemistry and Molecular Pharmacology

115404, Moscow, 6th Radialnaya str., 24/14

Elena V Mashkovtseva

Institute of Cytochemistry and Molecular Pharmacology

115404, Moscow, 6th Radialnaya str., 24/14

Lyudmila N Maksimova

Institute of Cytochemistry and Molecular Pharmacology

Email: ludamaksimova@mail.ru
115404, Moscow, 6th Radialnaya str., 24/14

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Copyright (c) 2015 Nartsissov Y.R., Sheshegova E.V., Mashkovtseva E.V., Maksimova L.N.

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