Contents of volatile fatty acids in condensate of exhaused air in smoking persons


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Smoking annually leads to nearly six million deaths. Exposure of tobacco smoke components to cells leads to significant metabolic shifts, including lipid metabolism disorders. Volatile fatty acids are important biologically active substances, the metabolism of which may be important in the development of bronchopulmonary pathology. Aim. To study the quantitative shifts in the spectrum of short-chain fatty acids in the condensate of exhaled air from smokers. Methods: Gas-liquid chromatography in the condensate of exhaled air was used to determine: C2 - acetic, C3 - propionic, C4 - oil, isoC4 - isobutyric, C5 - valeric, C6 - caproic, C7 - heptane acid. Results. Be level of acetate, butyrate, isobutyrate, valerate, heptane increases in the condensate of exhaled air of smokers. As the smoking experience and the number of cigarettes smoked per day increase, the concentration of exhaled volatile fatty acids increases, which may indicate metabolic, physiological disorders in the respiratory organs and, possibly, the beginning of the development of any pathological processes.

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作者简介

T. Karavaeva

Chita State Medical Academy

Email: KaTany1@yandex.ru
Ph.D. (Med.), Associate Professor, Department of Chemistry and Biochemistry

P. Tereshkov

Chita State Medical Academy

Email: tpp6915@mail.ru
Ph.D. (Med.), Leading Research Scientist, Laboratory of Clinical and Experimental Biochemistry and Immunology, Scientific Research Institute of Molecular Medicine

M. Maximienya

Chita State Medical Academy

Email: mmv4510@mail.ru
Ph.D. (Biol.), Senior Research Scientist, Laboratory of Clinical and Experimental Biochemistry and Immunology, Scientific Research Institute of Molecular Medicine

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