Glucogenic and ketogenic effects in the light of introducing their skeletons into Krebs cycle
- 作者: Malinovsky A.V.1
-
隶属关系:
- Branch of FSUE "EPM" FMBA of Russia
- 期: 卷 25, 编号 5 (2022)
- 页面: 3-11
- 栏目: Biological chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/112953
- DOI: https://doi.org/10.29296/25877313-2022-05-01
- ID: 112953
如何引用文章
详细
After catabolism of all amino acids became known, attempts to make up a scheme of ways of introducing amino acids'carbon skeletons in different stages of oxydative transformations in Krebs cycle were made several times; amino acids having been united in groups. However, all schemes which are known so far have some faults particularly referring to glucogenic or ketogenic effects of one or another amino acid. Moreover, the conclusion to which the scientists came with reference to this effect, do not always correspond to the scheme. Faults both in the sceme and conclusions concerning glucogenic and ketogenic effects of amino acids are not admissible; these effects can be clearly observed in case of diabetes: introduction of glucogenic amino acids into the organism reduces the severity of ketosis whereras that of ketogenic increases it. In the present paper a scheme of introducing amino acids'carbon skeletons into Krebs cycle, specified on the basis of modern data of amino acids' transformation, and conclusions of glucogenic or ketogenic effects of one or another amino acid that fully correspond to the scheme are given. The results should be taken into account when dealing with diabetes and some other diseases.
全文:
![受限制的访问](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
作者简介
A. Malinovsky
Branch of FSUE "EPM" FMBA of Russia
编辑信件的主要联系方式.
Email: info@eco-vector.com
Process Engineer, Special Design and Technology Bureau "Biofizpribor"
St. Petersburg, Russia参考
- Большая медицинская энциклопедия. Издание второе. М.: Советская энциклопедия. 1961; т. 21; ст. «Окисление биологическое».
- Ленинджер А. Биохимия. М.: Мир. 1976.
- Биохимия: Учеб. для медицинских вузов под ред. Е.С. Северина. М.: ГЭОТАР. 2015.
- Большая медицинская энциклопедия. Изд. 2-е. М.: Изд-во медицинской литературы. 1956; т. 1; ст. «Азотистый обмен».
- Большая медицинская энциклопедия. Изд. 2-е. М.: Советская энциклопедия. 1961; т. 21; ст. «Оксипролин».
- Рудзит В.К. Триптофан. Монография. М.: Медицина. 1973.
- Дэгли С., Никольсон Д. Метаболические пути. М.: Мир. 1973.
- Большая медицинская энциклопедия. Издание третье. М.: Медицина. 1974; т. 1; ст. «Азотистый обмен».
- Малиновский А.В. Обладает ли треонин кетогенным действием? Вопросы биологической, медицинской и фармацевтической химии. 2020; 6:34.
- Покровский А.А. Роль биохимии в развитии науки о питании. М.: Наука. 1974.
- Watanabe R., Fujimura, S., Kadowaki, M, Ishibashi, T. Effects of dietary threonine levels on the threonine-degrading enzyme activities and tissue threonine related amino acid concentration in rats. Anim. Sci. Technol. (Jpn.). 1998; 69: 108-116.
- House J.D., Hall B.N., Brosnan J.T. Threonine metabolism in isolated rat hepatocytes. Am. J. Physiol. Endocrinol. Metab. 2002; 281. Е1300-Е1307.
- Nagao K., Bannai M., Seki S., Mori M., Takahashi M. Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats. Amino Acids. 2009. March.
- Badawi A.A-B. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects.Int. J. Tryptophan. Res. 2017; 10. 1-20. https://doi.org/10.1177/1178646917691938
- Ленинджер А. Биохимия. М.: Мир. 1985.
- Малиновский А.В. Схема и выводы Ленинджера нуждаются в уточнениях. Биоорганическая химия. 2022; 48(1): 53-62.
补充文件
![](/img/style/loading.gif)