Identification of tinctures by the polarimetric method


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Relevance. The ambiguity of the observed therapeutic effects of tinctures and the absence of pharmacopoeial articles require the development of new approaches to their quality control. In this work, for the first time, the polarimetry method and the dynamic light scattering method were used to identify tinctures with sedative and cardiotonic effects. The purpose. To develop the methods of polarimetry and dynamic light scattering for quality control of valerian, motherwort and hawthorn tinctures Material and methods. Objects of research: tinctures of rare series from different manufacturers. Methods: polarimetry (POL-1/2, Atago, Japan); dynamic light scattering method - DLS (Zetasizer Nano ZS, Malvern, UK). Results. Polarimetric method established that tinctures are optically active environment. This made it possible to develop a method for identifying tinctures with sedative and cardiotonic effects, which is based on measuring the optical rotation angle of 95% ethanol dilutions of different multiplicities. When diluting valerian tincture in a ratio of 1:40, the angle of optical rotation is in the range of -0.10° 2.5° were excluded from consideration as unstable dispersed systems. Conclusions. A polarimetric method for identifying tinctures based on measuring the optical activity of dilutions with 95% ethanol has been developed. The angle of optical rotation of valerian tinctures is in the range -0.10°2.5° as unstable disperse systems.

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作者简介

A. Syroeshkin

Peoples' Friendship University of Russia

Email: livmatter@mail.ru
Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and Toxicological Chemistry, Medical Institute

D. Ogotoeva

Peoples' Friendship University of Russia

Email: livmatter@mail.ru

Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute

D. Galkina

Peoples' Friendship University of Russia

Email: livmatter@mail.ru

Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute

M. Dzhavakhyan

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: livmatter@mail.ru

Dr.Sc. (Pharm.), Chief Research Scientist

T. Elizarova

«KoAl Farmanaliz» LLC

Email: livmatter@mail.ru

Ph.D. (Pharm.), General Manager

E. Uspenskaya

Peoples' Friendship University of Russia

Email: livmatter@mail.ru

Dr.Sc. (Pharm.), Professor, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute

T. Pleteneva

Peoples' Friendship University of Russia

编辑信件的主要联系方式.
Email: livmatter@mail.ru

Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute

参考

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2. Fig. 1. Examples of optically active compounds contained in the raw materials of valerian, motherwort and hawthorn (* - centers of chirality)

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3. Fig. 2. Dependence of the optical activity (αav±SD) of valerian tincture on the dilution ratio with 95% ethanol (A) or water (B) and on the concentration of ethanol for a 1:40 dilution for two weeks (C)

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4. Fig. 3. Optical activity kinetics of tinctures of valerian, motherwort and hawthorn from different manufacturers and individual series

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5. Fig. 4. Size spectra of dynamic light scattering (DLS) of freshly prepared water (left) and alcohol (right) dilutions of valerian tincture; (Iav±SD), n=3, p<0.05.

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6. Fig. 5. Correlation of optical activity α° with z-potential (a) and number of photon pulses (b) for hawthorn tincture

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