Fat-soluble antioxidant vitamins in female and male reproduction (review)

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Introduction. According to data provided in a WHO report published on April 4, 2023, about 17.5% of the adult population or every sixth person in the world suffers from infertility. The problem of infertility does not have regional, national and social manifestations, which creates an urgent need to study its causes and develop safe, effective and affordable treatment methods.

The purpose of this work was to analyze scientific data on the effect of fat-soluble antioxidant vitamins on human reproductive function and to assess the prospects of antioxidant therapy in the treatment of female and male infertility.

Material and Methods. The PRISMA principle was used to search and select articles. The search for publications for review was carried out in the Cochrane databases (Cochrane Group on Gynecology and Infertility Treatment (CGF), MedLine (PubMEd), ScienceDirect (Elsevier), as well as the Russian scientific electronic library eLibrary.Ru, including neurosearch.

Results. Study of the functional state Numerous studies have been devoted to the human reproductive system in conditions of deficiency of fat-soluble vitamins and antioxidants, during which the relationship between the content of carotenoids, retinol, α-tocopherol and other fat-soluble antioxidants in the blood of women and men and reproductive dysfunction has been identified. An analysis and synthesis of published clinical studies has been carried out. on the influence of fat-soluble antioxidant vitamins on the human reproductive system, and it has been established that the prospects for antioxidant therapy in the treatment of infertility are being investigated, while focusing on the deficiency of antioxidants, in particular vitamins A, E, D and carotenoids, as a significant factor causing reproductive dysfunction systems. Their role and potential impact on improving the reproductive health of men and women is discussed.

Conclusions. The lack of representation of antioxidant therapy regimens in standard clinical guidelines for the treatment of female and male infertility is due to the current lack of evidence of adequate quality confirming its effectiveness and safety. In this regard, the need to design and conduct high-quality randomized placebo-controlled clinical trials to determine the effectiveness and safety of antioxidant therapy in the treatment of infertility is emphasized.

全文:

受限制的访问

作者简介

V. Malyavina

Kuban State Medical University

编辑信件的主要联系方式.
Email: malyavinavv@gmail.com
ORCID iD: 0000-0002-9498-2003
SPIN 代码: 9693-8221

Ph.D. (Pharm.), Associate Professor, Associate Professor of the Department of Pharmacy

俄罗斯联邦, 4 Sedina str., Krasnodar, 350063

M. Khochava

Kuban State Medical University

Email: hochavamr@ksma.ru
ORCID iD: 0000-0002-0066-3598
SPIN 代码: 6077-6575

Ph.D. (Pharm.), Associate Professor, Associate Professor of the Department of Profile Hygienic Disciplines,
Epidemiology and General Hygiene

俄罗斯联邦, 4 Sedina str., Krasnodar, 350063

O. Bykova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: vilar8@rambler.ru
ORCID iD: 0000-0002-6032-2357
SPIN 代码: 1721-8472

North Caucasus branch, Ph.D. (Agricul.), Director

俄罗斯联邦, village Vasyurinskaya, Dinskoy district, Krasnodar Territory, 353225

参考

  1. Vsemirnaya organizaciya zdravooxraneniya: oficz. sajt. URL: https://www.who.int/ru/health-topics/infertility#tab=tab_1 (data obrashheniya: 16.06.2024). (In Russ.).
  2. Federal State Budgetary Institution "National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov" Ministry of Health of the Russian Federation: ofic. website. URL: https://ncagp.ru/index.php?_t8=323#:~:text=В%20России%20бесплодны%204-4,причину%20бесплодия%20. (In Russ.).
  3. Labygina A.V., Kolesnikova L.I., Grebenkina L.A. i dr. Retinol content and reproductive disorders in residents of Eastern Siberia (literature review). 2018; 4:51-58. doi: 10.33396/1728-0869-2018-4-51-58. (In Russ.).
  4. Clagett-Dame M, Knutson D. Vitamin A in reproduction and development. Nutrients. 2011; Apr; 3(4): 385–428. doi: 10.3390/nu3040385.
  5. Nizamutdinova R.I., Nagimova E.M. Hygiene: health and prevention: A collection of materials of the IV Interregional scientific and practical conference with international participation, Samara, November 25, 2020. Samara: Samara State Medical University. Controls-Samara LLC, 2020: 101-103. (In Russ.).
  6. Ross A.C., Ternus M.E. Vitamin A as a hormone: recent advances in understanding the actions of retinol, retinoic acid, and beta carotene. J Am Diet Assoc. 1993; Nov; 93(11): 1285–1290; quiz 1291-2. doi: 10.1016/0002-8223(93)91956-q.
  7. Ghyasvand T., Goodarzi M.T., Amiri I., Karimi J., Ghorbani M. Serum levels of lycopene, beta-carotene, and retinol and their correlation with sperm DNA damage in normospermic and infertile men. Int. J. Reprod. Biomed. 2015; Dec; 13(12): 787–792.
  8. Sheiko L.D., Mamina V.P., Balezin S.L. The possibility of using beta-carotene as a therapeutic and prophylactic agent in reproductive toxicology. Problems of reproduction. 2001; 7(6): 37 –41. (In Russ.).
  9. Galchenko E.V. The use of antioxidants in the complex therapy of women with ovarian dysfunction and dishormonal mastopathy: specialty 14.01.01 "Obstetrics and gynecology": dissertation for the degree of candidate of medical Sciences. Irkutsk, 2007: 123 p. (In Russ.)
  10. Kudinova E.G. Deficiency of vitamins and micronutrients and features of reproductive health in women. breast cancer. Mother and child. 2022; 5(3): 182-187. doi: 10.32364/2618-8430-2022-5-3-182-187. (In Russ.).
  11. Babichev V.N., Yeltseva T.V. Vitamins and their role in the reproductive system functioning. Problems of Endocri-nology. 1993; 39(2): 51–55; https://doi.org/10.14341/probl11978. (In Russ.).
  12. Abashova E.I. Yarmolinskaya M.I., Misharina E.V. The role of vitamin D in reproduction. Doctor.Ru. 2018; 10(154): 37–42. doi: 10.31550/1727-2378-2018-154-10-37-42. (In Russ.).
  13. Bochkarnikova A.G., Trishkin A.G., Pustotina O.A., Moses V.G. "D-status" of patients with reproductive disorders. Fundamental and clinical medicine. 2018; 3(3): 6–11. (In Russ.)
  14. Tyuzikov I.A., Kalinchenko S.Y., Vorslov L.O., Titova Yu.A. Vitamin D, men's health and male reproduction. Andrology and genital surgery. 2013; 14(4): 36–44. (In Russ.).
  15. Adami L.N.G., Belardin L.B., Lima B.T. et al. Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress. Andrologia. 2018 Feb 2. doi: 10.1111/and.12959.
  16. Cicek N., Eryilmaz O.G., Sarikaya E., Gulerman C., Genc Y.J. Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. Assist Reprod Genet. 2012 Apr; 29(4): 325–328. doi: 10.1007/s10815-012-9714-1.
  17. Md Amin N.A., Sheikh Abdul Kadir S.H., Arshad A.H. et al. Are Vitamin E Supplementation Beneficial for Female Gynaecology Health and Diseases? Molecules. 2022; Mar 15; 27(6): 1896. doi: 10.3390/molecules27061896.
  18. Clagett-Dame M., DeLuca H.F. The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr. 2002; 22: 347–381. doi: 10.1146/annurev.nutr.22.010402.102745E.
  19. Pasquariello R., Anipchenko P., Pennarossa G.C. et al. Carotenoids in female and male reproduction. Phytochemistry. 2022 Dec; 204: 113459. doi: 10.1016/j.phytochem.2022.113459. Epub 2022 Sep 29.
  20. Bastos Maia S., Rolland Souza A.S., Costa Caminha M.F. et al. Vitamin A and Pregnancy: A Narrative Review. Nutrients. 2019; Mar 22; 11(3):81. doi: 10.3390/nu11030681.
  21. Smits R.M., Mackenzie-Proctor R., Fleischer K., Showell M.G. Antioxidants in fertility: impact on male and female reproductive outcomes. Fertil Steril. 2018 Sep; 110(4): 578–580. doi: 10.1016/j.fertnstert.2018.05.028.
  22. Bazhenov I.V., Filippova E.S. The role of oxidative stress in the pathogenesis of male infertility. Effective pharmacotherapy. 2018; 29:50-58.
  23. Kirilenko E.A., Onopko V.F. Oxidative stress and male fertility: a modern view of the problem. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2017; 2(114): 102-108. doi: 10.12737/article_59a614fd84d146.40261567. (In Russ.).
  24. Leisegang K., Henkel R., Agarwal A. Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor. Curr. Pharm. Des. 2017 Nov 28; 23(30): 4438–4450. doi: 10.2174/1381612822666161019150241.
  25. Kuznetsova I.V. The role of oxidative stress and antioxidant protection in human reproduction. Obstetrics and gynecology. 2016; 3: 116-121. doi: 10.18565/aig.2016.3.116-121. (In Russ.)
  26. Berezina D.A., Kudryavtseva E.V., Gavrilov I.V. The role of oxidative stress in the female reproductive system: a literature review Perm Medical Journal. 2023; 40(4): 62-72. doi: 10.17816/pmj40462-72. (In Russ.).
  27. Agarwal A., Gupta S., Sharma R.K. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005 Jul 14; 3: 28. doi: 10.1186/1477-7827-3-28.
  28. Imran M., Ghorat F., Ul-Haq I. et al. Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders. Antioxidants (Basel). 2020. Aug 4; 9(8): 706. doi: 10.3390/antiox9080706.
  29. Caseiro M., Ascenso A., Costa A. et al. Lycopene in human health. S.LWT. 2020; 127: 109323. doi: 10.1016/j.lwt.2020.10932.
  30. Abouelgreed T.A., Amer M.A.H. et al. The influence of oral antioxidants on men with infertility: a systemic review. Arch Ital Urol Androl. 2024 May 2; 96(2): 12323. doi: 10.4081/aiua.2024.12323.
  31. Tremellen K., Miari G., Froiland D. et al. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust. N. Z. J. Obstet Gynaecol. 2007 Jun; 47 (3): 216–221. doi: 10.1111/j.1479-828X.2007.00723.x.
  32. Moslemi M.K., Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int. J. Gen. Med. 2011 Jan 23; 4: 99–104. doi: 10.2147/IJGM.S16275.
  33. Hashemi Z., Sharifi N., Khani B. et al. The effects of vitamin E supplementation on endometrial thickness, and gene expression of vascular endothelial growth factor and inflammatory cytokines among women with implantation failure. J. Matern. Fetal. Neonatal. Med. 2019 Jan; 32(1): 95–102. doi: 10.1080/14767058.2017.1372413.
  34. Nashar El. A., Salama K., Benha El. A.-Deen. et al. Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated By ICSI: A Randomized Clinical Trial. J. Appl. Sci. 2021; 5: 1–6. doi: 10.21608/BJAS.2020.135845.
  35. O'Flaherty C., Scarlata E. Oxidative stress and reproductive function: The protection of mammalian spermatozoa against oxidative stress. Reproduction. 2022; Oct 26; 164(6): F67-F78. doi: 10.1530/REP-22-0200.
  36. Agarwal A., Leisegang K., Majzoub A. et al. Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence. World J Mens Health. 2021 Apr; 39(2): 233–290; https://doi.org/10.5534/wjmh.200196.
  37. Dimitriadis F., Borgmann H., Struck J.P. et al. Antioxidant Supplementation on Male Fertility-A Systematic Review. Antioxidants (Basel). 2023; Mar 30; 12(4): 836. doi: 10.3390/antiox12040836.
  38. Abouelgreed T.A., Amer M.A., Mamdouh H. et al. The influence of oral antioxidants on men with infertility: a systemic review. Arch Ital Urol Androl. 2024; May 2; 96(2): 12323. doi: 10.4081/aiua.2024.12323.
  39. De Ligny W., Smits R.M., Mackenzie-Proctor R. et al. Antioxidants for male subfertility. Cochrane Database Syst. Rev. 2022; May 4; 5(5): CD007411. doi: 10.1002/14651858.CD007411.pub5.
  40. Showell M.G., Mackenzie-Proctor R., Jordan V., Hart R.J. Antioxidants for female subfertility. Cochrane Database Syst. Rev. 2020; Aug 27; 8(8): CD007807. doi: 10.1002/14651858.CD007807.pub4.
  41. Lundin K., Bentzen J.G., Bozdag G. et al. Good practice recommendations on add-ons in reproductive medicine. ESHRE Add-ons working group. Hum Reprod. 2023; Nov 2; 38(11): 2062–2104. doi: 10.1093/humrep/dead184.
  42. Clinical guidelines "Female infertility" URL: https://base.garant.ru/404763029/.
  43. Clinical guidelines "Male infertility" URL: https://base.garant.ru/400871573/.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russkiy Vrach Publishing House, 2025