Smoking as one of the predictors of the severity of the condition of patients suffering from a new coronavirus infection

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The relationship between smoking and the lung damage volume in patients with a confirmed new coronavirus infection diagnosis, hospitalized in a temporary infectious hospital for the treatment of patients suffering from a new coronavirus infection and community-acquired pneumonia was evaluated. This was in the Odintsovo District’s Patriot Park of the Moscow region. Smoking cigarettes, both active and passive, as well as exposure to tobacco smoke on the body, are important upper and lower respiratory tract infection risk factors due to local immune response suppression. Nevertheless, data from a number of international studies indicate a significantly lower number of hospitalized smoking patients compared to non-smokers. These indicators were investigated as the percentage and degree of lung damage, smoking history, the number of cigarettes smoked per day, and the smoker's index. In the course of the study, the data on a smaller percentage of smokers admitted to inpatient treatment were confirmed in comparison with non-smokers and smokers in the general population. There was no statistically significant difference in the volume of lung damage between smoking and non-smoking patients according to the chest organs computed tomography. At the same time, there was an increase in the volume of lung tissue damage, depending on the smoking experience. This is apparently due to the irreversible changes formation in lung tissue against a long-term smoking background. The median age of smoking patients was 56 years with a variation from 46 to 68 years. The minimum and maximum ages were 29 and 82. The median lung lesion was 32% with a variation from 23% to 39%. The minimum and maximum lung damage is 10% and 40%, respectively. A moderate correlation was found between the smoking experience and the volume of lung damage. An increase in lung damage by 0.309% should be expected with an increase in smoking experience by one full year. There was also no statistically significant difference in the number of cigarettes smoked per day and the smoker’s index.

Full Text

Restricted Access

About the authors

Alexey А. Mikhaylov

Military Medical Academy of S.M. Kirov

Author for correspondence.
Email: auri8@mail.ru
ORCID iD: 0000-0001-5656-2764
SPIN-code: 3957-6107

Adjunct

Russian Federation, Saint Petersburg

Ruslan Т. Velibekov

Military Medical Academy of S.M. Kirov

Email: mr.ruslan.velibekov@gmail.com
SPIN-code: 5406-2909

Cadet

Russian Federation, Saint Petersburg

Fedor M. Ivashinenko

Military Medical Academy of S.M. Kirov

Email: fedoremissaria@gmail.com
SPIN-code: 5894-3296

Cadet

Russian Federation, Saint Petersburg

Ruslan I. Litvinenko

Military Medical Academy of S.M. Kirov

Email: litvius@yandex.ru
ORCID iD: 0000-0001-8435-9958
SPIN-code: 8981-4000

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

References

  1. Zyl-Smit RN, Richards G, Leone FT. Tobacco smoking and COVID-19 infection. Lancet Respir Med. 2020;8(7):475–481. doi: 10.1016/S2213-2600(20)30239-3
  2. Mustafaev ShM. Analiz riska zdorov'yu pri upotreblenii kal'yanov, ehlektronnykh kuritel'nykh izdelii, sistem dlya nagrevaniya tabaka, kuritel'nykh smesei i tabachnoi/bestabachnoi (nikotinosoderzhashchei) produktsii. Proceeding of the X All-Russian science and practice conference with international participation: «Analiz riska zdorov'yu-2020 sovmestno s mezhdunarodnoi vstrechei po okruzhayushchei srede i zdorov'yu Rise-2020 i kruglym stolom po bezopasnosti pitaniya». 13–15 May 2020. Permian. P. 667–676. (In Russ.).
  3. Evropeiskoe regional'noe byuro VOZ. Doklad o tendentsiyakh v oblasti upotrebleniya tabaka v Evrope 2019 g. Copenhagen: Vsemirnaya organizatsiya zdravookhraneniya, 2019. 68 с. (In Russ.).
  4. Polverino F. Cigarette Smoking and COVID-19: A Complex Interaction. Am J Respir Crit Care Med. 2020;202(3):471–472. doi: 10.1164/rccm.202005-1646LE
  5. Panasyuk EhI, Agurbash AN. Sravnitel'naya otsenka tyazhesti zabolevaniya COVID-19 u kuryashchikh patsientov. Proceeding of the international science and practice conference: «Meditsina i zdravookhranenie v sovremennom obshchestve». 15 Aug 2020; Penza. Penza: Nauka i prosveshchenie, 2020. P. 9–11. (In Russ.).
  6. Ivanov MA, Agurbash AN, Panasyuk EhI. Kurenie kak faktor riska bolee tyazhelogo techeniya COVID-19. Proceeding of the All-Russian science and practice conference with international participation: «Profilakticheskaya meditsina -2020». 18–19 Nov 2020; Saint Petersburg. Saint Petersburg: North-Western State Medical University named after I.I. Mechnikov, 2020. P. 158–163. (In Russ.).
  7. Guan W-J, Ni Z-Y, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382: 1708–1720. doi: 10.1056/NEJMoa2002032
  8. Lawrence H, Hunter A, Murray R, et al. Cigarette smoking and the occurrence of influenza–Systematic review. J Infect. 2019;79(5): 401–406. doi: 10.1016/j.jinf.2019.08.014
  9. Leung JM, Sin DD. Smoking, ACE-2 and COVID-19: ongoing controversies. Eur Respir J. 2020;56(1):19–26. doi: 10.1183/13993003.01759-2020
  10. Shastri MD, Shukla SD, Chong WC, at al. Smoking and COVID-19: What we know so far. Respir Med. 2021;176:121–128. doi: 10.1016/j.rmed.2020.106237
  11. Leung JM, Yang CX, Tam A, et al. ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J. 2020;55(5):56–62. doi: 10.1183/13993003.00688-2020
  12. Zhao Q, Meng M, Kumar R, et al. The impact of COPD and smoking history on the severity of COVID-19: A systemic review and meta-analysis. J Med Virol. 2020;92(10):1915–1921. doi: 10.1002/jmv.25889
  13. Ivchenko EV, Kotiv BN, Ovchinnikov DV, Bucenko SA. Results of the work of the Military medical academy research institute of novel coronavirus infection problems through 2020–2021. Bulletin of the Russian Military Medical Academy. 2021;23(4):93–104. (In Russ.). doi: 10.17816/brmma83094
  14. Hamming I, Timens W, Bulthuis MLC, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2): 631–637. doi: 10.1002/path.1570
  15. Yаblonskiy PK, Sukhovskaya OA, Smirnova MA, Vasil’yev VS. Change in smoking behaviour during COVID-19 pandemic. Medical Alliance. 2021;9(3):89–95. (In Russ.). doi: 10.36422/23076348-2021-9-3-89-95
  16. Cai G, Bosse Y, Xiao F, et al. Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2. Am J Respir Crit Care Med. 2020;201(12):1557–1559. doi: 10.1164/rccm.202003-0693LE
  17. Liu W, Tao Z-W, Lei W, et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J. 2020;133(9):1032–1038. doi: 10.1097/CM9.0000000000000775
  18. Gambaryan MG, Drapkina OM. Tobacco smoking and COVID-19: an old enemy in a new guise. Review of current publications. Cardiovascular Therapy and Prevention. 2020;19(3):2604. (In Russ.). doi: 10.15829/1728-8800-2020-2604
  19. Kashyap VK, Dhasmana A, Massey A, et al. Smoking and COVID-19: Adding Fuel to the Flame. Int J Mol Sci. 2020;21(18):6581. doi: 10.3390/ijms21186581
  20. Williamson EJ, Walker AJ, Bhaskaran KJ, et al. Factors Associated with COVID-19-Related Hospital Death in the Linked Electronic Health Records of 17 Million Adult NHS Patients. OpenSAFELY. 2020;584:430–436. doi: 10.1038/s41586-020-2521-4
  21. Mehra MR, Desai SS, Kuy S, et al. Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. 2020;382:e102. doi: 10.1056/NEJMoa2007621
  22. Farsalinos K, Barbouni A, Niaura R. Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? Intern Emerg Med. 2020;15(5):845–852. doi: 10.1007/s11739-020-02355-7
  23. Salukhov VV, Kharitonov MA, Kryukov EV, et al. Topical issues of diagnostics, examination and treatment of patients with COVID-19-associated pneumonia in different countries and continents. Medical Council. 2020;(21):96–102. (In Russ.). doi: 10.21518/2079-701X-2020-21-96-102
  24. Cloëz-Tayarani I, Changeux J. Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. J Leukoc Biol. 2007;81(3):599–606. doi: 10.1189/jlb.0906544
  25. Cui W-Y, Li MD. Nicotinic modulation of innate immune pathways via α7 nicotinic acetylcholine receptor. J Neuroimmun Pharmacol. 2010;5(4):479–488. doi: 10.1007/s11481-010-9210-2
  26. Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol. 2002;2(5):372–377. doi: 10.1038/nri803
  27. Kolyubaeva SN, Kondratenko AA, Alkhazhe K, et al. Investigation of HLA-DRB1 and IL28 gene polymorphism in patients with varying severity of COVID-19 infection. Genes and cells. 2021;16(3):86–90. (In Russ.). doi: 10.23868/202110012
  28. Kryukov EV, Trishkin DV, Salukhov VV, Ivchenko IV. Opyt voennoi meditsiny v bor'be s novoi koronavirusnoi infektsiei. Vestnik Rossijskoj Akademii Nauk. 2022;92(7):699–706. (In Russ.). doi: 10.31857/S086958732207009X
  29. Wang J, Luo Q, Chen R, et al. Susceptibility Analysis of COVID-19 in Smokers Based on ACE2. Preprints. 2020:2020030078. doi: 10.20944/preprints202003.0078.v1
  30. Minnullin TI, Stepanov AV, Chepur SV, et al. Immunological aspects of SARS-CoV-2 coronavirus damage. Bulletin of the Russian Military Medical Academy. 2021;23(2):187–198. (In Russ.). doi: 10.17816/brmma72051
  31. Zhang W, Li H, Zhou M, et al. Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects. Front Immunol. 2022;13:826–889. doi: 10.3389/fimmu.2022.826889

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Regression function characterizing the dependence of lung damage on smoking experience

Download (57KB)
3. Fig. 2. Regression function characterizing the dependence of lung damage on the smoker's index

Download (57KB)

Copyright (c) 2022 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 77762 от 10.02.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies