Clinical evaluation of the effectiveness of the gel of rare-cut acrylic polymers with a complex of natural antimicrobial peptides FLIP-7 in the treatment of borderline skin burns

The effectiveness of the treatment of borderline skin burns using a gel of rare-sewn acrylic polymers with natural antimicrobial peptides FLIP-7 was evaluated. A total of 60 burned patients hospitalized in the Burn Center of Saint Petersburg Scientific Research Institute for First Aid named after I.I. Janelidze were examined during the period from 2019–2021. The following were evaluated: the general condition of patients, planimetric indicators, as well as the results of microscopic examination of smears-prints from the wound surface. This drug was established to be effective in the treatment of borderline skin burns from the first day of use. The burn wound areas upon use of FLIP-7 gel compared to wet-drying dressings and water-soluble ointment levomekol decreased by 6.25% and 8.6%, respectively. A complete restoration of the integrity of the skin was noted by the 7th treatment day, against the background FLIP-7 gel use. A complete restoration of skin integrity was noted by the 7th day of treatment, against the background of FLIP-7 gel use. The application of a hydrogel with a complex of natural antimicrobial peptides was demonstrated to have a pronounced antibacterial effect against most pathogenic microorganisms. Hence, the number of burn wound infection decreased by 35% by the 4th day from the treatment initiation. There was a possibility of reducing the analyzed indicator to 10% by the end of the week of local treatment with FLIP-7 gel, which indicates almost complete elimination of pathogenic microflora from the burn wound. It was proven that the humid environment conditions formed by hydrogel can stimulate the reparative regeneration processes. This was confirmed by the results of microscopic examination of smear prints, indicating a statistically significant increase in the concentration of fibroblasts on the wound surface by the 4^th day of observation compared with the results obtained before treatment initiation with FLIP-7 gel. Not a single case of side effect or undesirable phenomenon was recorded during course of the clinical study. The gel of rare-stitched acrylic polymers with natural antimicrobial peptides FLIP-7 is an effective means of local treatment of borderline skin burns, which provides not only optimal conditions for the course of reparative regeneration processes, but also actively eliminates pathogenic microflora, including polyresistant microorganisms strains.