HPgV infection: literature review


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Abstract

Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to 2020. Results: the history of the study of the virus, its structure, genetic heterogeneity, as well as the problem of epidemiology, tropism and pathogenesis of this infection are described. Due to the presence of a number of the virus properties, possible prospects of HPgV infection research for population genetics and gene therapy are reflected. The modern data on the relationship of HPgV infection with HIV infection, lymphomas and some other diseases are presented. A brief description of a relatively recently described HPgV-2 is presented. The problems of diagnosis and interpretation of HPgV infection in the Russian Federation and foreign countries are outlined. Conclusion: Although HPgV was originally described as the cause of hepatitis, it is not a cytopathic virus, and infection is not associated with the development of pathological processes.

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About the authors

Valeriy Viktorovich Litvinov

FSBEI HE «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: drlitvinov@mail.ru
Assistant professor, Department of pathology

Genrietta Gerhardovna Freynd

FSBEI HE «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: gfreynd@mail.ru
Head of the department of pathology

Vladimir Pavlovich Korobov

FSBSIPerm Federal Research Center «Institute of Ecology and Genetic of Microorganisms» Ural Office of the Russian Academy of Sciences

Email: korobov@iegm.ru
Head of the Laboratory of Microorganisms’ Biochemical Development

Anna Dmitrievna Shestakova

FSBI «National medical research center of Oncology named after N.N. Petrov» Ministry of Healthcare of the Russian Federation

Email: message19@rambler.ru
Resident doctor

References

  1. Stapleton J.T., Foung S., Muerhoff A.S., Bukh J., Simmonds P. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J. of General Virology. 2011; 92 (2): 233-46. https://doi.org/10.1099/vir.0.027490-0
  2. Stapleton J.T. GB virus type C/Hepatitis G. virus. Seminars in Liver Disease. 2003; 23 (2):137-48. https://doi.org/10.1055/s-2003-39943
  3. Smith D.B., Becher P., Bukh J., Gould E.A., Meyers G., Monath T. eds. Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flavi-viridae family. J. of General Virology. 2016; 97 (11): 2894-907. https://doi.org/10.1099/jgv.0.000612
  4. Epstein J.H., Quan P.-L., Briese T., Street C., Jabado O., Conlan S. eds. Identification of GBV-D, a Novel GB-like Flavivirus from Old World Frugivorous Bats (Pteropus giganteus) in Bangladesh. PLoS Pathogens. 2010; 6 (7): e1000972. https://doi.org/10.1371/journal.ppat.1000972
  5. Sibley S.D., Lauck M., Bailey A.L., Hyeroba D., Tumukunde A., Weny G. eds. Discovery and Characterization of Distinct Simian Pegiviruses in Three Wild African Old World Monkey Species. PloS One. 2014; 9 (6): e98569. https://doi.org/10.1371/journal.pone.0098569
  6. Adams M.J., King A.M.Q., Carstens E.B. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2013). Archives of Virology 2013; 158 (9): 2023-30. https://doi.org/10.1007/s00705-013-1688-5
  7. Heffron A.S., Lauck M., Somsen E.D., Townsend E.C., Bailey A.L., Sosa M., Eickhoff J., Capuano III.S., Newman C.M., Kuhn J.H., Mejia A., Simmons H.A., O'Connor D.H. Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis. Microorganisms. 2020; 8 (10): 1509. https://doi.org/10.3390/microorganisms8101509
  8. Lefkowitz E.J., Dempsey D.M., Hendrickson R.C., Orton R.J., Siddel S.G., Smith D.B. Virus taxonomy: The database of the International Committee on Taxonomy of Viruses (ICTV). Nucleic Acids Research. 2018; 46 (D1): 708-17. https://doi.org/10.1093/nar/gkx932
  9. Porter A.F., Pettersson J.H.O., Wei-Shan C., Harvey E., Rose K., Shi M., Eden J., Buchmann J., Moritz C., Holmes E.C. Metagenomic identification of diverse animal hepa-civiruses and pegiviruses. bioRxiv. 2020. https://doi.org/10.1101/2020.05.16.100149
  10. Tomlinson J.E., Kapoor A., Kumar A., Tennant B.C., Laverack M.A., Beard L., Delph K., Davis E., Schott Ii.H., Lascola K. eds. Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014-2018). J. of Veterinary Internal Medicine. 2019; 33 (1): 251-7. https://doi.org/10.1111/jvim.15368
  11. Xiang J., Klinzman D., McLinden J. eds. Characterization of hepatitis G. virus (GB-C Virus) particles: evidence for a nucleocap-sid and expression of sequences upstream of the E1 protein. J. of Virology 1998; 72 (4): 2738-44. https://doi.org/10.1128/jvi.72.4.2738-2744.1998
  12. Penin F., Dubuisson J., Rey F.A., Moradpour D., Pawlotsky J.M. Structural biology of hepatitis C. virus. Hepatology. 2004; 39 (1): 5-19. https://doi.org/10.1002/hep.20032
  13. Belyaev A.S., Chong S., Novikov A. eds. Hepatitis G. virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. J. of Virology 1998; 72 (1): 868-72. https://doi.org/10.1128/jvi.72.1.868-872.1998
  14. Walewski J.L., Keller T.R., Stump D.D., Branch A.D. Evidence for a new hepatitis C. virus antigen encoded in an overlapping reading frame. RNA. 2001; 7 (1): 710-21. https://doi.org/10.1017/s1355838201010111
  15. Taklual W., Tang S., Yue W. Effect of human pegivirus route of transmission on the genetic distribution of the virus: an institution based cross-sectional study Virology J. 2019; 16 (1): 50-6. https://doi.org/10.1186/s12985-019-1161-5
  16. Pavesi A. Origin and evolution of GBV-C/ Hepatits G. Virus and relationships with ancient human migrations. J. of Molecular Evolution. 2001; 53 (2): 104-13. https://doi.org/10.1007/s002390010198
  17. Feng Y., Zhao W., Feng Y., Dai J., Li Z., Zhang X. eds. A novel genotype of GB virus C: its identification and predominance among injecting drug users in Yunnan, China. PLoS One. 2011; 6 (10): e21151. https://doi.org/10.1371/journal.pone.0021151
  18. Mohr E.L., Murthy K.K., McLinden J.H., Xiang J., Stapleton J.T. The natural history of nonhuman gb virus c in captive chimpanzees. J. of General Virology 2011; 92 (1): 91-100. https://doi.org/10.1099/vin0.026088-0
  19. Santos L.M., Lobato R.C., Barral M.F.M., Goncalves C.V., da Hora V.P., Martinez A.M.B. Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV. International J. of Gynecology & Obstetrics. 2017; 138 (1): 113-8. https://doi.org/10.1002/ijgo.12175
  20. George S.L., Varmaz D., Stapleton J.T. GB virus C. replicates in primary T. and B. lymphocytes. The J. of Infectious Diseases. 2006; 193 (3): 451-4. https://doi.org/10.1086/499435
  21. Послова Л.Ю., Алексеев А.Б., Сергеева А.В., Ковалишена О.В., Шкарин В.В., Сенягина Н.Е., Бруснигина Н.Ф., Бутина Т.Ю. Оценка частоты и условий инфицирования вирусами TTV и HGV у детей с впервые установленным острым лимфобластным лейкозом на разных этапах лечения. Инфекция и иммунитет. 2019; 9 (1): 147-54.
  22. Bihl F., Castelli D., Marincola F. eds. Transfusion-transmitted infections. J. of Translational Medicine. 2007; 5 (1): 25-36. https://doi.org/10.1186/1479-5876-5-25
  23. Alter H.J. G-pers creepers, where'd you get those papers? A reassessment of the literature on the hepatitis G virus. Transfusion. 1997; 37 (6): 569-72. https://doi.org/10.1046/j.1537-2995.1997.37697335149.x
  24. Акимкин В.Г., Алимов А.В., Захарова Ю.А., Болгарова Е.В., Питерский М.В., Сисин Е.И. Обзор актуальных вопросов диагностики и профилактики гемоконтактных нозокомиальных вирусных инфекций. Вопросы вирусологии. 2019; 64 (6): 262-7
  25. Chivero E.T., Stapleton J.T. Tropism of human pegivirus (formerly known as GB virus C/ hepatitis G virus) and host immunomodula-tion: insights into a highly successful viral infection. J. of General Virology 2015; 96 (7): 1521-32. https://doi.org/10.1099/vir.0.000086
  26. Wunschmann S., Muller H.M., Stipp C.S., Hemler M.E., Stapleton J.T. In Vitro Interaction between Hepatitis C. Virus (HCV) Envelope Glycoprotein E2 and Serum Lipoproteins (LPs) Results in Enhanced Cellular Binding of Both HCV E2 and LPs. The J. of Infectious Diseases. 2006; 194 (8): 1058-67. https://doi.org/10.1086/507647
  27. Bhattarai N., McLinden J.H., Xiang J.H., Landay A.L., Chivero E.T., Stapleton J.T. GB virus C. particles inhibit T. cell activation via envelope E2 protein-mediated inhibition of TCR signaling. The J. of Immunology 2013; 190 (12): 6351-9. https://doi.org/10.4049/jimmunol.1300589
  28. Agnello V., Abel G., Elfahal M., Knight G.B., Zhang Q.X. Hepatitis C. virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proceedings of the National Academy of Sciences. 1999; 96 (22): 12766-71. https://doi.org/10.1073/pnas.96.22.12766
  29. Chivero E.T., Bhattarai N., Rydze R.T., Winters M.A., Holodniy M., Stapleton J.T. Human pegivirus RNA is found in multiple blood mononuclear cells in vivo and serum-derived viral RNA-containing particles are infectious in vitro. J. of General Virology 2014; 95 (6): 1307-19. https://doi.org/10.1099/vir.0.063016-0
  30. Bhattarai N., Stapleton J.T. GB virus C: the good boy virus? Trends in Microbiology 2012; 20 (3): 124-30. https://doi.org/10.1016/j.tim.2012.01.004
  31. Zhang W. eds. Effect of early and late GB virus C. viraemia on survival of HIV-infected individuals: a meta-analysis. HIV Medicine. 2006; 7 (3): 173-80. https://doi.org/10.1111/j.1468-1293.2006.00366.x
  32. Supapol W.B. eds. Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C. infection. The J. of Infectious Diseases. 2008; 197 (10): 1369-77. https://doi.org/10.1086/587488
  33. Koedel Y. eds. Peptides derived from a distinct region of GB Virus C. glycoprotein E2 mediate strain specific HIV-1 entry inhibition. J. of Virology 2011; 85 (14): 7037-47. https://doi.org/10.1128/jvi.02366-10
  34. Nunnari G. eds. Slower progression of HIV-1 infection in persons with GB virus C. co-infection correlates with an intact T-helper 1 cytokine profile. Annals of Internal Medicine. 2003; 139 (1): 26-30. https://doi.org/10.7326/0003-4819-139-1-20030701000009
  35. Moenkemeyer M. eds. GBV-C coinfection is negatively correlated to Fas expression and Fasmediated apoptosis in HIV-1 infected patients. Journal of Medical Virology 2008; 80 (11): 1933-40. https://doi.org/10.1002/jmv.21305
  36. N'Guessan K.F., Boyce C., Kwara A. eds. Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B. virus (HBV). Virus Genes. 2018; 54 (3): 361-7. https://doi.org/10.1007/s11262-018-1555-2
  37. Greenhalgh S., Schmidt R., Day T. Fighting the Public Health Burden of AIDS With the Human Pegivirus. Am. J. of Epidemiology. 2019; 188 (9): 1586-94. https://doi.org/10.1093/aje/kwz139
  38. Fama A., Xiang J., Link B.K., Allmer C., Klinzman D., Feldman A.L., Nowakowski G.S., Liebow M., Larson M.C., Maurer M.J., Ansell S.M., Novak A.J., Asmann Y.W., Slager S.L., Call T.G., Habermann T.M., Cerhan J.R., Stapleton J.T. Human Pegivirus infection and lymphoma risk and prognosis: a North American study. British J. of Haematology. 2018; 182 (5): 644-53. https://doi.org/10.1111/bjh.15416
  39. Fama A., Larson M.C., Link B.K., Habermann T.M., Feldman A.L., Call T.G., Ansell S.M., Liebow M., Xiang J., Maurer M.J. eds. Human pegivirus infection and lymphoma risk: A systematic review and meta-analysis. Clinical Infectious Diseases. 2020; 71 (5): 1221-8. https://doi.org/10.1093/cid/ciz940
  40. Giordano T.P., Henderson L., Landgren O., Chiao E.Y., Kramer J.R., El-Serag H., Engels E.A. Risk of Non-Hodgkin Lymphoma and Lymphoproliferative Precursor Diseases in US Veterans With Hepatitis C Virus. JAMA. 2007; 297 (18): 2010-7. https://doi.org/10.1001/jama.297.18.2010
  41. Keresztes K., Takacs M., Horanyi M., Miltenyi Z., Illes A. HCV and HGV infection in Hodgkin's disease. Pathology & Oncology Research. 2003; 9 (4): 222-5. https://doi.org/10.1007/bf02893381
  42. Bhattarai N., McLinden J.H., Xiang J., Mathahs M.M., Schmidt W.N., Kaufman T.M., Stapleton J.T. Hepatitis C. virus infection inhibits a Src-kinase regulatory phosphatase and reduces T. cell activation in vivo. PLOS Pathogens. 2017; 13 (2): e1006232. https://doi.org/10.1371/journal.ppat.1006232
  43. Charbonneau B., Maurer M.J., Ansell S.M., Slager S.L., Fredericksen Z.S., Ziesmer S.C., Macon W.R., Habermann T.M., Witzig T.E., Link B.K., Cerhan J.R., Novak A.J. Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study. Cytokine. 2012; 60 (3): 882-9. https://doi.org/10.1016/j.cyto.2012.08.028
  44. Tucker T.J., Smuts H.E., Eedes C., Knobel G.D., Eickhaus P., Robson S.C., Kirsch R.E. Evidence that the GBV-C/hepatitis G. virus is primarily a lymphotropic virus. J. of Medical Virology. 2000; 61 (1): 52-8. https://doi.org/10.1002/(sici)1096-9071(200005)61:1<52::aid-jmv8>3.0.co;2-l
  45. Nicolosi Guidicelli S., Lopez-Guillermo A., Falcone U., Conconi A., Christinat A., Rodriguez-Abreu D., Grisanti S., Lobetti-Bodoni C., Piffaretti J.C., Johnson P.W. eds. Hepatitis C. virus and GBV-C virus prevalence among patients with B-cell lymphoma in different European regions: a case-control study of the International Extranodal Lymphoma Study Group. Hematological Oncology. 2012; 30 (2): 137-42. https://doi.org/10.1002/hon.1015
  46. Bukowska-Ośko I., Perlejewski K., Pawełczyk A., Rydzanicz M., Pollak A., Popiel M., Cortés K.C., Paciorek M., Horban A., Dzieciątkowski T., Radkowski M., Laskus T. Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland. Emerging Infectious Diseases. 2018; 24 (10): 1785-94. https://doi.org/10.3201/eid2410.180161
  47. Fridholm H., 0stergaard S0rensen L., Rosenstierne M.W., Nielsen H., Sellebjerg F., Bengard Andersen A., Fomsgaard A. Human pegivirus detected in a patient with severe encephalitis using a metagen-omic pan-virus array. J. of Clinical Virology. 2016; 77: 5-8. https://doi.org/10.10Wj.jcv.2016.01.013
  48. Lauck M., Bailey A.L., Andersen K.G., Goldberg T.L., Sabeti P.C., O'Connor D.H. GB virus C. coinfections in West African Ebola patients. J. of Virology. 2015; 89 (4): 2425-9. https://doi.org/10.1128/jvi.02752-14
  49. Jones J.F., Kulkarni P.S., Butera S.T. eds. GB virus-C - a virus without a disease: We cannot give it chronic fatigue syndrome. BMC Infectious Diseases. 2005; 5 (1): 78-82. https://doi.org/10.1186/1471-2334-5-78
  50. Zhengwei Wan eds. Evidence that the second human pegivirus (HPgV-2) is primarily a lymphotropic virus and can replicate independent of HCV replication. Emerging Microbes & Infections. 2020; 9 (1): 485-95. https://doi.org/10.1080/22221751.2020.1730247

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