Molecular mechanisms of action of natural bioactive compounds in personalized medicine for the rehabilitation of cancer patients after chemo and radiation therapy

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The purpose of the study. To analyze scientific data on the molecular targets and mechanisms of action of key natural bioactive substances used to support cancer patients after chemotherapy and radiation therapy in the framework of personalized medicine. Personalized medicine is associated with the selection of targeted drugs based on tumor genomics, taking into account the bioindividuality of each patient, his molecular, physiological and behavioral characteristics. In the context of natural bioactive compounds, a personalized approach involves the study of interindividual variability in the metabolism of phytocomponents, polymorphisms of detoxification genes, and individual characteristics of molecular targets.

Material and methods. A systematic literature analysis was conducted for the period 2010-2024 in the databases Cyberleninka, PubMed, Cochrane Library, SAGE Premier, Springer, and Wiley Journals.

Results. The natural compounds with the greatest vector of development in the rehabilitation of cancer patients (mushrooms, phytopreparations, nutrients) and their molecular mechanisms are considered. Clinical studies have been analyzed, indicating the resources of natural compounds in reducing the toxic effects of antitumor therapy and accelerating the rehabilitation of patients, taking into account individual and molecular characteristics.

Conclusion. The use of natural bioactive compounds at the stage of rehabilitation of cancer patients is considered as an interdisciplinary approach requiring further validation of scientific data. Natural compounds, when used scientifically, can provide additional opportunities to support patients' health and improve their quality of life.

The integration of phytotherapy into oncology is an area that requires further study. Large multicenter RCTs in various populations are needed, and further study of the pharmacokinetics and interactions of drugs and natural compounds in the rehabilitation of cancer patients. A promising area is "molecular integrative oncology", which uses natural products in accordance with the molecular profile of the tumor and the patient.

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作者简介

Tatyana Potupchik

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1133-4447

Associate Professor of the Department of Pharmacology and Clinical Pharmacology with a Postgraduate Education Course, Сandidate of medical sciences

俄罗斯联邦, Partizan Zheleznyak str., 1, Krasnoyarsk, 660022

Olga Usoltseva

SibPribor Limited Liability Company

Email: usolceva@baikal-legend.ru
ORCID iD: 0000-0002-6947-0057

scientific research coordinator, Candidate of Medical Sciences

俄罗斯联邦, Trilissera St., 87, Irkutsk, 664047

Sergey Kupov

LLC Oncology Clinic

Email: kupov@onco.rehab
ORCID iD: 0009-0009-8696-9579

Candidate of Medical Sciences, Oncologist, Chief Physician, Scientific and Practical Center for Supportive Cancer Therapy, Integrative and Immuno-Oncology "Onco Rehab"

俄罗斯联邦, Stadionnaya str., 2, Orekhovo-Zuyevo, Moscow Region, 142603

Olga Veselova

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: Veselovaof@mail.ru
ORCID iD: 0000-0002-6126-665X

Head of the Department of Pharmacology and Clinical Pharmacology with a postgraduate course, Candidate of Medical Sciences

俄罗斯联邦, Partizan Zheleznyak str., 1, Krasnoyarsk, 660022

Sofya Efremova

Peoples' Friendship University of Russia named after Patrice Lumumba

Email: moniiica999@yandex.ru
ORCID iD: 0009-0002-2090-4106

6th-year Student

俄罗斯联邦, Miklukho-Maklaya St., 6, Moscow, 117198

Elina Baskakova

Kursk State Medical University

Email: elina.bas46.8@gmail.com
ORCID iD: 0009-0000-9812-667X

6th-year Student

俄罗斯联邦, Karl Marx St., 3, Kursk, Kursk region, 305004

Alena Boyarko

Orenburg State Medical University of the Ministry of Health of the Russian Federation

Email: boyarko.alyona2002@mail.ru
ORCID iD: 0009-0006-1966-9240

5th-year Student

俄罗斯联邦, Sovetskaya St., 6, Orenburg, 460000

参考

  1. Goetz L.H., Schork N.J. Personalized medicine: motivation, challenges, and progress. Fertil Steril. 2018; 109 (6): 952–63. doi: 10.1016/j.fertnstert.2018.05.006
  2. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell. 2011; 144 (5): 646–74. doi: 10.1016/j.cell.2011.02.013
  3. Seyfried T.N., Shelton L.M. Cancer as a metabolic disease. Nutr Metab (Lond). 2010; 7: 7. doi: 10.1186/1743-7075-7-7
  4. Latte-Naor S., Mao J.J. Putting Integrative Oncology Into Practice: Concepts and Approaches. J. Oncol. Pract. 2019; 15 (1): 7–14. doi: 10.1200/JOP.18.00554
  5. Goetz L.H., Schork N.J. Personalized medicine: motivation, challenges, and progress. Fertil Steril. 2018; 109 (6): 952–63. doi: 10.1016/j.fertnstert.2018.05.006
  6. Lee R.T., Kwon N., Wu J., To C., To S., Szmulewitz R., Tchekmedyian R. et al. Prevalence of potential interactions of medications, including herbs and supplements, before, during, and after chemotherapy in patients with breast and prostate cancer. Cancer. 2021; 127 (11): 1827–35. doi: 10.1002/cncr.33324
  7. Liu Y., Shi X., Tian Y., Zhai S., Liu Y., Xiong Z., Chu S. An insight into novel therapeutic potentials of taxifolin. Front Pharmacol. 2023; 14: 1173855. doi: 10.3389/fphar.2023.1173855
  8. Lu Y., Jia Y., Xue Z., Li N., Liu J., Chen H. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). 2021; 13 (9): 1441. doi: 10.3390/polym13091441
  9. Suthar M., Dufossé L, Singh S.K. The Enigmatic World of Fungal Melanin: A Comprehensive Review. J. Fungi (Basel). 2023; 9 (9): 891. doi: 10.3390/jof9090891.
  10. Chaudhry G.-S., Akim A.M., Sung Y.Y., Sifzizul T.M.T. Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Pharmacol. 2022; 13. doi: 10.3389/fphar.2022.842376
  11. Zoi V., Galani V., Lianos G.D., Voulgaris S., Kyritsis A.P., Alexiou G.A. The Role of Curcumin in Cancer Treatment. Biomedicines. 2021; 9 (9): 1086. doi: 10.3390/biomedicines9091086
  12. Liao L.-Y., He Y.-F., Li L., Meng H., Dong Y.-M., Yi F., Xiao P.-G. et al. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide Chin Med. 2018; 13: 57. doi: 10.1186/s13020-018-0214-9
  13. Li S., So T.H., Tang G., Tan H.Y., Wang N., Ng B.F.L., Chan C.K.W. et al. Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Front Oncol. 2020; 10: 599073. doi: 10.3389/fonc.2020.599073.
  14. Loef M., Walach H. Quality of life in cancer patients treated with mistletoe: a systematic review and meta-analysis. BMC Complement Med Ther. 2020; 20 (1): 227. doi: 10.1186/s12906-020-03013-3
  15. Pelzer F., Loef M., Martin D.D., Baumgartner S. Cancer-related fatigue in patients treated with mistletoe extracts: a systematic review and meta-analysis. Support Care Cancer. 2022; 30 (8): 6405–18. doi: 10.1007/s00520-022-06921-x
  16. De Araujo D.P., Pereira P.T.V.T., Fontes A.J.C., Marques K.D.S., de Moraes Е.B., Guerra R.N.M., Garcia J.B.S.. The use of guarana (Paullinia cupana) as a dietary supplement for fatigue in cancer patients: a systematic review with a meta-analysis. Support Care Cancer. 2021; 29 (12): 7171–82. doi: 10.1007/s00520-021-06242-5
  17. Schauss A.G., Tselyico S.S., Kuznetsova V.A., Yegorova I. Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol). International J. of Toxicology. 2015; 34 (2): 162–81. doi: 10.1177/1091581815576975
  18. Zhang J., Zheng Y., Hong B., Ma L., Zhao Y., Zhang S., Sun S. et al. Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes. Biomed Pharmacother. 2022; 155: 113727. doi: 10.1016/j.biopha.2022.113727
  19. Gmoshinski I.V., Ananyan M.A., Shipelin V.A. et al. Effect of dihydroquercetin supplementation on the toxic properties of nickel nanoparticles in the experiment. Foods and Raw Materials. 2023; 11 (2): 232–42. doi: 10.21603/2308-4057-2023-2-572
  20. Усольцева О.Н., Оленников Д.Н., Потупчик Т.В. Оценка качества и биологической активности БиоДигидрокверцетина. Фармация. 2022; 71 (8): 5–14. [Usoltseva O.N., Olennikov D.N., Potupchik T.V. Assessment of the quality and biological activity of Bio-Dihydroquercetin. Pharmacy. 2022; 71 (8): 5–14. doi: 10.29296/25419218-2022-08-01 (in Russian)].
  21. Belosludtseva N.V., Uryupina T.A., Pavlik L.L. et al. Structural and functional alterations in heart mitochondria in a rat model of isoprenaline-induced myocardial injury and their correction with water-soluble Taxifolin. Int. J. Mol. Sci. 2024; 5 (21): 11596. doi: 10.3390/ijms252111596
  22. Хундерякова Н.В., Белослудцева Н.В., Хмиль Н.В. и др. Исследование влияния водорастворимой формы дигидрокверцетина при его введении per os на энергетический обмен в лимфоцитах крови крыс с экспериментальной кардиомиопатией. Вопросы питания. 2021; 90 (6): 50–8. [Hunderyakova N.V., Belosludtseva N.V., Khmil N.V. et al. Investigation of the effect of the water-soluble form of dihydroquercetin when administered per os on energy metabolism in blood lymphocytes of rats with experimental cardiomyopathy. Nutrition issues. 2021; 90 (6): 50–8. doi: 10.33029/0042-8833-2021-90-6-50-58 (in Russian)].
  23. Alalykina E.S., Sergeeva T.N., Ananyan M.A. et al. A Watersoluble form of dihydroquercetin reduces LPS-induced astrogliosis, vascular remodeling, and mRNA VEGF-a levels in the substantia nigra of aged rats. J. Neurosci Neurol Disord. 2024; 8: 014–9. doi: 10.29328/journal.jnnd.1001092
  24. Уракова В.А., Ананян М.А., Алалыкина Е.С. и др. Оценка влияния дигидрокверцетина на организацию микроциркуляторного русла черной субстанции мозга крыс разного возраста при введении липополисахарида. Материалы IV Российской научно-практической конференции «Фундаментальные, клинические и трансляционные аспекты нейронаук», Ижевск. Ижевский государственный университет. 2022. [Urakova V.A., Ananyan M.A., Alalykina E.S. et al. Evaluation of the effect of dihydroquercetin on the organization of the microcirculatory bed of the substantia nigra of the brain of rats of different ages with lipopolysaccharide administration. Proceedings of the IV Russian Scientific and Practical Conference "Fundamental, Clinical and translational aspects of Neuroscience", Izhevsk. Izhevsk State University. 2022. URL: https://www.elibrary.ru/item.asp?edn=rfdmkm (in Russian)].
  25. Shubina V.S., Kozina V.I., Shatalin Y.V. A Comparative Study of the Inhibitory Effect of Some Flavonoids and a Conjugate of Taxifolin with Glyoxylic Acid on the Oxidative Burst of Neutrophils. Int. J. Mol. Sci. 2023; 24 (20): 15068. doi: 10.3390/ijms242015068.
  26. Ганов Д.И. Использование качественных природных БАДов в качестве сопроводительной терапии при радикальном лучевом лечении и химиотерапии онкоурологических пациентов. Врач. 2021; 32 (11): 76–9. [Ganov D.I. The use of high-quality natural dietary supplements as an accompanying therapy for radical radiation treatment and chemotherapy of oncourological patients. The Doctor. 2021; 32 (11): 76–9. doi: 10.29296/25877305-2021-11-16 (in Russian)].
  27. Suthar M. Dufossé L., Singh S.K. The Enigmatic World of Fungal Melanin: A Comprehensive Review. J. fungi (Basel). 2023; 9 (9): 891. doi: 10.3390/jof9090891
  28. Bartusik-Aebisher D., Serafin I., Dynarowicz K. et al. Photodynamic therapy and associated targeting methods for treatment of brain cancer. Front. Pharmacol. 2023; 14: 1250699. doi: 10.3389/fphar.2023.1250699
  29. Огарков Б.Н., Шишкин Н.А., Огаркова Г.Р., Самусенок Л.В. Способ получения пигмента-меланина из базидиоспор трутовых грибов. Патент №2565178 от 20.10.2015 г., Федеральная служба по интеллектуальной собственности РФ. [Ogarkov B.N., Shishkin N.A., Ogarkova G.R., Samusenok L.V. Method of obtaining pigment melanin from basidiospores of tinder fungi. Patent No.2565178 dated 10/20/2015, Federal Service for Intellectual Property of the Russian Federation. (in Russian)].
  30. Усольцева О.Н., Потупчик Т.В., Полютова А.А. Меланины: функциональные свойства и возможности применения в медицинской практике. Фармация. 2024; 73 (6): 39–47. [Usoltseva O.N., Potupchik T.V., Politova A.A. Melanins: functional properties and application possibilities in medical practice. Pharmacy. 2024; 73 (6): 39–47. doi: 10.29296/25419218-2024-06-06 (in Russian)].
  31. Арсаханова Г.А. Меланин в структуре противодействия стрессовым явлениям организма. Международный журнал прикладных наук и технологий INTEGRAL. 2020; 6: 5. [Arsakhanova G.A. Melanin in the structure of countering stress phenomena of the body. International J. of Applied Sciences and Technologies INTEGRAL. 2020; 6: 5. doi: 10.24411/2658-3569-2020-10117 (in Russian)].
  32. Freuding M., Keinki C., Micke O., Buentzel J., Huebner J. Mistletoe in oncological treatment: a systematic review: Part 1: survival and safety. J. Cancer Res Clin. Oncol. 2019; 145 (3): 695–707. doi: 10.1007/s00432-018-02837-4
  33. Freuding M., Keinki C., Kutschan S., Micke O., Buentzel J., Huebner J. Mistletoe in oncological treatment: a systematic review : Part 2: quality of life and toxicity of cancer treatment. J. Cancer Res Clin. Oncol. 2019; 145 (4): 927–39. doi: 10.1007/s00432-018-02838-3
  34. Jin X., Ruiz Beguerie J., Sze D.M., Chan G.C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016; 4 (4): CD007731. doi: 10.1002/14651858.CD007731.pub3
  35. Zoi V., Galani V., Lianos G.D., Voulgaris S., Kyritsis A.P., Alexiou G.A. The Role of Curcumin in Cancer Treatment. Biomedicines. 2021; 9 (9): 1086. doi: 10.3390/biomedicines9091086
  36. Xiao Q., Zhu W., Feng W., Lee S.S., Leung A.W., Shen J., Gao L. et al. A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy. Front Pharmacol. 2019; 9: 1534. doi: 10.3389/fphar.2018.01534.
  37. Cai S., Xie L.-W., Xu J.-Y., Zhou H., Yang C., Tang L.-F., Tian Y. et al. Epigallocatechin3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against RadiationInduced Intestinal Injury in Mice. Front. Oncol. 2022; 12: 848107. doi: 10.3389/fonc.2022.848107
  38. Yennurajalingam S., Reddy A., Tannir N.M., Chisholm G.B., Lee R.T., Lopez G., Escalante C.P. et al. High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report. Integr Cancer Ther. 2015; 14 (5): 419–27. doi: 10.1177/1534735415580676
  39. Vashi R., Patel B.M., Goyal R.K. Keeping abreast about ashwagandha in breast cancer. J. Ethnopharmacol. 2021; 269: 113759. doi: 10.1016/j.jep.2020.113759
  40. Bower J.E., Lacchetti C., Alici Y., Barton D.L., Bruner D., Canin B.E., Escalante C.P. et al. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update. J. Clin. Oncol. 2024; 42 (20): 2456–87. doi: 10.1200/JCO.24.00541

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