Kisspeptins: molecular mechanisms of respiratory system pathology

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The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and mechanisms of development of lung pathology, as well as the development of adequate methods for diagnosing, treating and preventing diseases of the respiratory system, carried out at the molecular and cellular levels, is not only an important, but also an extremely urgent task of biomedicine. As is known, the violation of homeostasis between cell proliferation and apoptosis leads to inflammatory changes and/or fibrosis of the lung tissue. The purpose of this review was to systematize scientific data on the expression of kisspeptins and their function in the pathology of the respiratory system. Material and methods. The expression of kisspeptins and their receptors was analyzed in pulmonary fibrosis, bronchial asthma, and non-small cell lung cancer. In addition, the role of kisspeptins in the development of the body’s immune response to viral infections in the cells of the ciliated epithelium of the upper respiratory tract has been shown. Conclusion. More and more data from modern studies demonstrate the involvement of kisspeptins and their participation in the regulation of the cell cycle, limiting cell metastasis, and other processes.

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作者简介

Mikhail Paltsev

Lomonosov Moscow State University

Email: mpaltzev@gmail.com

Director of the Center of Immunology and Molecular Biomedicine, Faculty of Biology

俄罗斯联邦,

Anna Drobintseva

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg State Pediatric Medical University

Email: info@spbniif.ru

Senior Researcher, Center of Molecular Biomedicine

俄罗斯联邦,

Ekaterina Mironova

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg Institute of Bioregulation and Gerontology

Email: katerina.mironova@gerontology.ru

Senior Researcher, Center of Molecular Biomedicine

俄罗斯联邦,

Ekaterina Paltseva

Russian Academy of Sciences

Email: paltseva-k@yandex.ru

Professor of RAS, Doctor of Medical Sciences

俄罗斯联邦,

Ngoc Do

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg State University; Vietnam Military Medical University

Email: dongochophvqy@gmail.com

postgraduate student of the Department of Pathology, Faculty of Medicine

俄罗斯联邦,

Ulyana Novak-Bobarykina

St. Petersburg State University

Email: ulyana.boba0304@mail.ru

post-graduate student of the Department of Pathology, Faculty of Medicine

俄罗斯联邦,

Daria Leontyeva

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg Institute of Bioregulation and Gerontology

编辑信件的主要联系方式.
Email: info@spbniif.ru

Research assistant, Center of Molecular Biomedicine

俄罗斯联邦,

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2. Scheme of formation of kisspeptins from pre-pro-kisspeptin encoded by the kiss1 gene [modified from 2]

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