Kisspeptins: molecular mechanisms of respiratory system pathology

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Abstract

The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and mechanisms of development of lung pathology, as well as the development of adequate methods for diagnosing, treating and preventing diseases of the respiratory system, carried out at the molecular and cellular levels, is not only an important, but also an extremely urgent task of biomedicine. As is known, the violation of homeostasis between cell proliferation and apoptosis leads to inflammatory changes and/or fibrosis of the lung tissue. The purpose of this review was to systematize scientific data on the expression of kisspeptins and their function in the pathology of the respiratory system. Material and methods. The expression of kisspeptins and their receptors was analyzed in pulmonary fibrosis, bronchial asthma, and non-small cell lung cancer. In addition, the role of kisspeptins in the development of the body’s immune response to viral infections in the cells of the ciliated epithelium of the upper respiratory tract has been shown. Conclusion. More and more data from modern studies demonstrate the involvement of kisspeptins and their participation in the regulation of the cell cycle, limiting cell metastasis, and other processes.

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About the authors

Mikhail Aleksandrovich Paltsev

Lomonosov Moscow State University

Email: mpaltzev@gmail.com

Director of the Center of Immunology and Molecular Biomedicine, Faculty of Biology

Russian Federation,

Anna Olegovna Drobintseva

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg State Pediatric Medical University

Email: info@spbniif.ru

Senior Researcher, Center of Molecular Biomedicine

Russian Federation,

Ekaterina Sergeevna Mironova

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg Institute of Bioregulation and Gerontology

Email: katerina.mironova@gerontology.ru

Senior Researcher, Center of Molecular Biomedicine

Russian Federation,

Ekaterina Mikhailovna Paltseva

Russian Academy of Sciences

Email: paltseva-k@yandex.ru

Professor of RAS, Doctor of Medical Sciences

Russian Federation,

Ngoc Hop Do

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg State University; Vietnam Military Medical University

Email: dongochophvqy@gmail.com

postgraduate student of the Department of Pathology, Faculty of Medicine

Russian Federation,

Ulyana Aleksandrovna Novak-Bobarykina

St. Petersburg State University

Email: ulyana.boba0304@mail.ru

post-graduate student of the Department of Pathology, Faculty of Medicine

Russian Federation,

Daria Olegovna Leontyeva

St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg Institute of Bioregulation and Gerontology

Author for correspondence.
Email: info@spbniif.ru

Research assistant, Center of Molecular Biomedicine

Russian Federation,

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Supplementary files

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1. JATS XML
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2. Scheme of formation of kisspeptins from pre-pro-kisspeptin encoded by the kiss1 gene [modified from 2]

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