Comparison of cytokine-inducing Activity of Different Types of Burkholderia's Antigens
- Authors: Proshina OB1, Zukova SI1, Piven NN1, Khrapova NP1, Avrorova IV1, Drefs NM1
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- Issue: Vol 3, No 2 (2006)
- Pages: 44-46
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/117809
- ID: 117809
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Abstract
The purpose of this work was to study the cytokinе-inducing activity of antigens of the melioidosis agent (Burkholderia pseudomallei) and its nonpathogenic type (Burkholderia thailandensis). In experiments in vitro on BALB/c mice macrophages and lymphocytes induced by water-salt extracts of Burkholdeias the activity of lymphokines and monokines was studied. The interrelation between the protective properties of Burkholderia's antigens and some parameters of its cytokin-inducing activity (the level of expression of Fc-receptors on neutrophils, phagocytic activity of macrophages and cytotoxic activity of TNF-α for mice fibroblasts L-929) was shown.
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References
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