ROLE OF POLYAMINES SYSTEM IN PATHOGENESISAND TREATMENT OF REGENERATIVEAND PLASTIC HEART FAILURE
- Authors: Khloponin DP1, Khloponin DP1
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Affiliations:
- Issue: Vol 5, No 2 (2008)
- Pages: 62-64
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/117988
- ID: 117988
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Abstract
Polyamines (putrescine, spermidine, & spermine) are associated with an ongoing myocardial injury in the failing heart. The cardioprotective effect of (3-blockers during heart failure treatment is partly explained by polyamines metabolism modulation. Cardioselective p1-blocker nebivolol is shown to normalize the myocardial level of putrescine, spermidine & spermine, which are essentially disturbed in adriamycin-induced regenerative & plastic heart failure in rats.
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References
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