CLINICOPATHOGENETIC IMPORTANCE OF ANALYSIS OF PURINE METABOLISM ENZYME ACTIVITY IN LYMPHOCYTE LYSATES AND ERYTHROCYTES OF PATIENTS WITH OSTEOARTROSIS

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Abstract

Activities of adenosine deaminase (ADA), adenosine monophosphate deaminase (AMPHDA) and adenin deaminase
(AD) were determined depending on clinical features of the disease in lyzates of lymphocytes and erythrocytes in blood of 52 patients with ostheoarthrosis. The results of the investigation demonstrated that the greatest changes in enzymatic
activity were observed in patients with synovitis and a high degree of functional insufficiency of the joints. A severe course of the disease was accompained by a considerable reduction of the activity of ADA in lymphocytes and a high activity of ADA, AMPHDA and AD in erythrocytes. Investigation of enzymatic activity promoted the control of objectivity and effectiveness of treatment.

References

  1. Бадокин В. В. // Русский медицинский журнал. 2006. Т. 14, № 25. C. 1824-1828.
  2. Базоркина Д. Н., Эрдес Ш. // Научно-практическая ревматология. 2005. № 6. С. 79-85.
  3. Карпищенко А. Н. Медицинские лабораторные технологии. Справочник. СПб: Интермедика, 2002. 600 с.
  4. Лила А. М. // Русский медицинский журнал. 2007. Т. 15, № 5. С. 331-334.
  5. Насонов Е. Л. // Consilium Medicum. 2001. № 9. С. 408-415.
  6. Ушакова И. С. Клинико-диагностическое значение исследования активности ферментов адениловой ветви пуринового метаболизма в лизатах лимфоцитов, эритроцитов и плазме крови больных ревматоидным артритом: дис. ... канд. мед. наук. Волгоград, 2007. 201 с.

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Copyright (c) 2009 Gerusov Y.I., Zborovskaya I.A., Martem'yanov V.F., Bedina S.A., Mozgovaya E.E., Gerusov Y.I., Zborovskaya I.A., Martemjanov V.F., Bedina S.A., Mozgovaya E.E.

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