THE ROLE OF LEPTIN AND NEUROPEPTIDE Y IN PATHOGENESIS OF REPRODUCTIVEDYSFUNCTIONS IN ADOLESCENT GIRLS WITH ANOREXIA NERVOSA
- Authors: Andreeva VO1, Andreeva VO1
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Affiliations:
- Issue: Vol 6, No 4 (2009)
- Pages: 84-87
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/118076
- ID: 118076
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Abstract
Serum leptin and neuropeptide Y levels have been determined in 2 studied groups of patients and in the control
group. A decreased leptin level was found at the anorectic stage, and hyperproduction of leptin was found at the stage of reduction of anorexia nervosa. It was also determined that leptin level is not depend on BMI. Hypoleptinemia of anorectic
stage was accompanied by a decreased neuropeptide Y level, which indicates formation of resistance to the low leptin level
that may be caused by a disorder of leptin transport through the hematoencephalic barrier and by hypoinsulinemia.
group. A decreased leptin level was found at the anorectic stage, and hyperproduction of leptin was found at the stage of reduction of anorexia nervosa. It was also determined that leptin level is not depend on BMI. Hypoleptinemia of anorectic
stage was accompanied by a decreased neuropeptide Y level, which indicates formation of resistance to the low leptin level
that may be caused by a disorder of leptin transport through the hematoencephalic barrier and by hypoinsulinemia.
References
- Богданова Е. А. Гинекология детей и подростков. - М.: МИА 2000. - С. 226-230.
- Зайчик А. Ш., Чурилов Л. П. Основы общей патологии. - СПб.: ЭЛБИ, 2001. - 688 с. 3.
- Международная классификация болезней (10-й пересмотр). - М., 1999. 4.
- Ожирение. Этиология, патогенез, клинические аспекты: Руководство для врачей / Под ред. И. И. Дедова, Г. А. Мельниченко. - М.: МИА, 2004.
- Frieling H., Wilhelm J., Fiszer R. // J. of Neural Transmission. - 2005. - № 112 (7). - Р. 979-985.
- Holtkamp K., Hebebrand J., Mika C. // J. of Neural Transmission. - 2003. - № 110. - Р. 427-435
- Inui А. // Molecular Psychiatry. - 2001. - № 6. - Р. 620-624.
- Mantzoroz C. S. // Annals of the New York Academy of Science. - 2000. - № 900. - Р. 174-183.
- Oswiecimska J., Ziora K., Geisler G. // NeuroEndocrinol-Letters. - 2005. - № 26 (4). - Р. 301-304.
- Perfetto F., Tarquini R., Simonini G. // Annals of the Rheumatic Diseases. - 2005. - № 64. - Р. 149-152
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