Vol 6, No 4 (2009)

Articles

METHOD OF ESTIMATING EFFECTIVENESS OF IMPLEMENTING MEDICALADVANCES INTO PRACTICE

Andreeva I.L., Andreeva I.L.

Abstract

The paper describes a method of estimating the ffectiveness of implementing medical advances into health care practice on the basis of innovative result with financial leverage, precluded economic damage, therapeutic effect and economic benefit from cost cutting, etc. we present an information system making it possible to perform a comparative analysis of effectiveness of research for the sake of enhancing its quality and effectiveness.
Journal of Volgograd State Medical University. 2009;6(4):3-11
pages 3-11 views

PERSPECIVES AND PROBLEMS OF NANOPHARMACOLOGY

Kosolapov V.A., Spasov A.A., Kosolapov V.A., Spasov A.A.

Abstract

Nanotechnologies are one of key trends in the development of modern medicine and pharmacology in particular. It is associated with enormous possibilities towards optimization of drug properties and development of newer medicines using the unique properties of nanoparticles.
Journal of Volgograd State Medical University. 2009;6(4):12-16
pages 12-16 views

МODIFICATION OF INTRABONE IMPLANTS SURFACES: MODERN RESEARCH AND NANOTECHNOLOGIES

Kalita V.I., Malanin D.A., Mamaeva V.A., Mamaev A.I., Komlev D.A., Derevyanko I.V., Novochadov V.V., Lantsov Y.A., Suchilin I.A., Kalita V.I., Malanin D.A., Mamaeva V.A., Mamaev A.I., Komlev D.A., Derevyanko I.V., Novochadov V.V., Lantsov Y.A., Suchilin I.A.

Abstract

This review includes information about characteristics and properties of various coatings for implan ts used in traumatology and orthopedics. We discuss modern nanotechnologies of manufacturing textured and bioceramic coatings with antimicrobial properties for titanium implants. Results of experimental research confirm osteoinductional properties of porous and bioceramic coatings.
Journal of Volgograd State Medical University. 2009;6(4):17-22
pages 17-22 views

MODEL OF OPTIMIZING IMPLEMENTATIONOF RESEARCH FINDINGS INTO HEALTH CARE

Andreeva I.L., Andreeva I.L.

Abstract

An information monitoring system was developed for the purpose of controlling implementation of research findings in health care of Russian Federation. This system helps to regulate, systematize and make a complex use of information of on-site work, which is an additional factor optimizing the implementation. A process approach to optimization at the expense of restructuring was complemented with a resource component. The proposed model is both workable and effective.
Journal of Volgograd State Medical University. 2009;6(4):23-29
pages 23-29 views

IMPACT OF AMINALON ON PARAMETERSOF CEREBRAL MICROCIRCULATION OF DISADAPTED SWIMMERSIN VARIOUS TYPES OF SYSTEMIC HEMODYNAMICS

Likhodeeva .A., Spasov A.A., Mandrikov V.B., Isupov I.B., Lichodeeva V.A., Spasov A.A., Mandrikov V.B., Isupov I.B.

Abstract

Aminalon (0,25g) taken by swimmers as a means of rehabilitation facilitated restoration of biochemical status and optimized cerebral blood flow in the types of systemic hemodynamics.
Journal of Volgograd State Medical University. 2009;6(4):29-32
pages 29-32 views

PARAMETERS OF LIPID PEROXIDATION, ANTIOXIDANT PROTECTIONIN OSTEOARTHROSIS

Aleksenko E.Y., Govorin A.V., Aleksenko E.Y., Govorin A.V.

Abstract

Some parameters of lipid peroxidation, antioxidant protection and lipid spectrum in patients with primary osteoarthrosis, evaluating pathogenetic importance of detected changes were investigated. Patients with OA revealed an increase in initial and intermediate products and lipid peroxidation, increased level of low density lipoprotein and triglycerides, a decrease in parameters of antioxidant protection.
Journal of Volgograd State Medical University. 2009;6(4):33-36
pages 33-36 views

CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS

Chernova S.I., Plokhov V.N., Chernova S.I., Plohov V.N.

Abstract

The content of proinflammatory сytokines IL-1 β, TNF- α and IL-6 in patients with atherosclerosis of brachiocephalic arteries were studied. Direct correlation communication between the total area of atherosclerotic lesion, quantity of stenotic arteries and the content of pro-inflammatory cytokines are shown. The interrelation of disorder of lipid indicators with level proinflammatory cytokines is noted.
Journal of Volgograd State Medical University. 2009;6(4):36-39
pages 36-39 views

HISTOMORPHOLOGICAL CHANGES IN KIDNEYS UNDER IMPACTOF ELECTROMAGNETIC PULSE WAVE IN EXPERIMENT

Klochkov V.V., Klochkov A.V., Klochkov V.V., Klochkov A.V.

Abstract

In this research we studied the damaging effect of electro-magnetic pulse waves on renal tissue of rats. Using four control groups we tested the protective properties of vitamin E, glycine, emoxipine and erythropoetin against EM waves. Depending on the results of these tests we analysed histomorphological changes in kidney tissue samples.
Journal of Volgograd State Medical University. 2009;6(4):40-43
pages 40-43 views

24-HOUR AMBULATORY BLOOD PRESSURE MONITORING PECULARITIESIN ELDERLY PATIENTS WITH AFFECTIVE DISORDERS

Statsenko M.E., Kalashnikova Y.S., Statsenko M.E., Kalashnikova J.S.

Abstract

As a result of our study was restored that elderly patients with affective disorders had a grater risk target organs damage because of statistically significant evidence of systolic blood pressure (SBP) variability in the day, SBP morning elevation parameter and diastolic blood pressure (DBP) morning elevation velocity increasing, and also the peakers prevalence in the daily index of SBP and DBP. It was statistically significant evidence of isolated systolic hypertension among this patient's category.
Journal of Volgograd State Medical University. 2009;6(4):44-46
pages 44-46 views

DYNAMICS OF CATECHOLAMINE INTERHEMISPERE ASYMMETRYOF RATS IN FIRST MONTH OF POSTNATAL ONTOGENESIS

Ovsyannikov V.G., Kapliev A.V., Ovsjannikov V.G., Kapliev A.V.

Abstract

Laterality changes of catecholamines (CA): adrenaline (A), noreadrenaline (NA), dopamine (DA) in the structures of brain hemispheres of male white rats was studied from their for four weeks. The general domination sinistrocerebral CA and «mixed» type of CA-profile with dextral A and NA components and sinistral laterality of DA was found in newborn animals. Left side CA-asymmetry was contrasted due to the dextral NA-component inverse in the cortex and hippocampus during the appearance of vision period. Unipolar sinistral CA-profle and the increase of laterality grade of all its elements was formed by the age of four weeks. Interhemispere CA-profile of hippocampus was practically unchanged in comp arison with appearance of vision period.
Journal of Volgograd State Medical University. 2009;6(4):47-50
pages 47-50 views

STRUCTURAL-FUNCTIONAL PECULIARITIES OF CARDIOVASCULAR SYSTEMIN MIGRANTS OF THE FIRST GENERATION IN THE FAR NORT

Omel'chenko N.V., Salamatina L.V., Popov A.I., Svaykina E.V., Omelchenko N.V., Salamatina L.V., Ророv A.I., Svaikina E.V.

Abstract

Aim of the research was to study the peculiarities of left ventricular geometry in migrants of the first generation in the Far North. The concentric type of hypertrophy of left ventricle - the most non-favourable in prognostically - was prevailed
Journal of Volgograd State Medical University. 2009;6(4):51-54
pages 51-54 views

STUDY OF NEW ANTIOXIDANTS STABILIZING ELTON BALNEOLOGICAL REMEDY

Dronova N.S., Simonyan A.V., Dronova N.S., Simonyan A.V.

Abstract

Estimation of antioxidation activity of the new antioxidants GMBC-1 and ferulic acid in comparison with dibunol was performed. This study was carried out using the model of autooxidation of the lipid complex of balneological remedy «Elton» when heated and exposed to light. GMBC-1 was noted to have the highest activity reducing the formation rate of primary and secondary oxidation products.
Journal of Volgograd State Medical University. 2009;6(4):54-56
pages 54-56 views

INFLUENCE OF ENVIRONMENTAL TEMPERATURE ON SUPERFICIAL AND DEEPTEMPERATURES OF LOWER EXTREMITY IN PATIENTS WITH VARICOSITY

Zamechnik T.V., Larin S.I., Stern N.A., Ovcharenko N.S., Andriyanov A.Y., Zamechnic T.V., Larin S.I., Stern N.A., Ovcharenko N.S., Andrianov A.J.

Abstract

Our purpose was to study the correlative association between the environmental temperature and shin temperatures - infra-red (IRТ) and microwave (deep or RТМ) temperatures - in healthy people and patients with varicosity (VD) with varying degrees of chronic venous insufficiency (CVI). 37 healthy patients and 64 patients with VD of the lower extremity were studied. The temperature was registered in 12 points of each shin. As a result, we have determined that in healthy patients an increase of environmental temperature resulted in directly proportional IRТ change (factor of correlation from 0,6 till 0,48), in VD С2-С3 (CVI 0-1 items) the factor of correlation raised essentially (from 0,86 till 0,74), at patients VD С4-С6 (CVD degree 3) the factor of correlation between IRT and environmental temperature amounted to 0,78-0,54. The deep temperature in healthy patients did not depend on temperature of the environment (factor of correlation from 0,05 to - 0,21), in patients with VD С1-С3 (CVD degree 0-1) the factor of correlation was considerably higher and amounted to 0,55-0,46, in patients with VD С4-С6 (CVD degree 3) the factor of correlation also amounted to 0,62-0,46.
Journal of Volgograd State Medical University. 2009;6(4):57-60
pages 57-60 views

PECULIARITIES OF HIPPOCAMPUS STRUCTURE IN ELDERLY AND SENILEFEMALES WITH CEREBRAL ATHEROSCLEROSIS ACCORDING TO SOMATOTYPES

Gorelik E.V., Smirnov- A.V., Krayushkin A.I., Grigor'eva N.V., Gorelik E.V., Smirnov A.V., Krayushkin A.I., Grigoryeva N.V.

Abstract

Somatotypes monitoring of elderly and senile women with cerebral atherosclerosis were determined. The results of quantitative and qualitative morphological study of hippocampus in women of different somatotypes and different age with cerebral atherosclerosis were obtained.
Journal of Volgograd State Medical University. 2009;6(4):61-63
pages 61-63 views

SOME INDICATORS OF HARD DENTAL TISSUES DISEASESIN VOLGOGRAD STUDENTS OF YEMEN REPUBLIC

Mikhal'chenko V.F., Al'-Sakkaf Mukhammed Khasan -., Petrukhin A.G., Michalchenko V.F., Al-Sakaf Mohammed Hasson -., Petrukhin A.G.

Abstract

The incidence of fluorosis and caries lesions in students from Yemen coming to do courses in institutions of higher education of Volgograd was studied. The study showed that the changes in nutrition, daily routine, physical activity as well as climatic and geographical conditions result in a higher incidence of caries lesions. Fluorosis was diagnosed in 67,7 of the examined students, which proves these students had been residing in endemic area of these diseases from birth.
Journal of Volgograd State Medical University. 2009;6(4):64-65
pages 64-65 views

DIFFERENTIAL EXPRESSION OF CYTOKINE GENES IN MICE INFECTEDBY BURKHOLDERIA PSEUDOMALLEI AND B. THAILANDENSIS

Perepelitsyna S.V., Alekseev V.V., Zakharova I.B., Plekhanova N.G., Viktorov D.V., Perepelitsyna S.V., Alekseev V.V., Zakharova I.B., Plekhanova N.G., Viktorov D.V.

Abstract

Using RT-PCR technique, the differences in cytokine genes expression in mice infected by Burkholderia pseudomallei и B. thailandensis strains were investigated. The maximal mRNA level of IFN- γ and IL-12, belongs to Th1-type cytokine profile of immune responce, was revealed in mice infected by avirulent B. thailandensis. The acute melioidosis caused by B. pseudomallei 100, contrastly, was characterized by termination of IFN- γ and IL-12 production and increase of IL-10 mRNA quantity in latest stages of observation. The transcription profiles of cytokine genes in mice infected by attenuated mutant B. pseudomallei 56770 99/10 was more related to case of B. thailandensis, however apparent similarity was matched in early stages of infection only. The obtained results demonstrate clear differences in immune response during infection caused by B. pseudomallei and B. thailandensis, аnd a given approach may be useful to investigate the traits of Burkholderia pathogenesis on molecular level.
Journal of Volgograd State Medical University. 2009;6(4):66-69
pages 66-69 views

ENDOTHELIAL FUNCTION AND CARDIOVASCULAR REMODELININ ARTERIAL HYPERTENSION

Grigoricheva E.A., Sigidova L.V., Grigoricheva E.A., Sigidiova L.V.

Abstract

Ultrasound study of the heart and vessels was performed in 105 patients with arterial hypertension and 20 apparently healthy individuals. Normal endothelial function was noted in 26 patients (24 %), signs of endothelial dysfunction - in 79 patients (76 %). A disrupted ability of the brachial artery to relax corresponded to decreased blood flow in the medial cerebral artery and parenchymatous renal blood flow (with an increased creatinin level). Patients with left ventricular hypertrophy revealed an endothelial reaction in the form of increased endothelial shift (increased velocity without an increase in vascular diameter), slowed-down time of vascular diameter restoration and decreased hemostatic ability of the vascular wall.
Journal of Volgograd State Medical University. 2009;6(4):69-72
pages 69-72 views

DYNAMICS OF TISSUE IGG AFTER GASTROPLASTY OF LIVER, SPLEEN AND KIDNEY WOUNDS IN THE EXPERIMENT

Musatov O.V., Zurnadzhan S.A., Khayrulin Y.K., Musatov O.V., Zurnadjan S.A., Hajrulin J.K.

Abstract

Evidence of general immunomorphological regularities of reparative processes in the liver, spleen and kidney wounds after their plasty with a seromuscular flap of the large curvature of the stomach on a vascular pedicle has been carried out on 135 rabbits. The method of direct immunofluorescence by Coons determined the quantity IgG in auto transplants, wounds of organs, layers between them, and also in donor wounds of the stomach, from where the flaps were taken. The follow-up period was from 1 to 360 days. The revealed tissue diffusion and transport IgG in wounds of injured organs most intensively occurred in the first 7 days. The gastric flap, being originally «a tissue drainage», smoothes out the consequences of ischemia around the wounds, accelerates the process of their purification and organization. The increase of IgG from 7th till 60-th day indicates an«effect of it accumulation» and creation of IgG depot IgG in it.
Journal of Volgograd State Medical University. 2009;6(4):72-75
pages 72-75 views

OPERATIVE ACCSESS TO ATRERIA CAROTIS FOR CAROTID RECONSTRACTION

Shestakov A.I., Yusupov R.K., Khafizov A.R., Akhmetvaleev A.V., Shestakov A.I., Yusupov R.H., Hafizov A.R., Ahmetvaleev A.V.

Abstract

Reconstruction arteria carotis at ischemic defeats of a brain often operation is surgery of vessels. Postperative wounds affect on mentel a condition of the person. For reduction of fabrics and the best cosmetic effect miniaccess to arteria carotis. Techncal equipment access is developed and results are resulted.
Journal of Volgograd State Medical University. 2009;6(4):75-78
pages 75-78 views

ЕXTERNAL ATTRIBUTES OF DYSPLASIA OF CONNECTIVE TISSUE IN CHILDRENWITH VARIOUS CONGENITAL CLEFT OF UPPER LIP AND PALATE

Vodolatskiy M.P., Evsev'eva M.E., Rekvava Z.A., Vodolatski M.P., Evsevieva M.E., Rekvava Z.A.

Abstract

The study was about the phenotypical attributes of dysplasia of connective tissue in 102 children (aged from 1 to 14 years) with various forms of congenital cleft of upper lip and palate. The reports showed the presence of external attributes of dysplasia in all children with congenital cleft of upper lip and palate. Maximum number of these features was found in children with bilateral cleft of upper lip and palate. Based upon this study we can conclude that the anomaly is more of a systemic pathology of the connective tissue.
Journal of Volgograd State Medical University. 2009;6(4):78-80
pages 78-80 views

ORAL COLONISATION RESISTANCE IN HEALTH AND DISEASE

Matisova E.V., Kramar' V.S., Klimova T.N., Matisova E.V., Kramar V.S., Klimova T.N.

Abstract

Normal microflora is an important part of the oral cavity microecosystem; it provides colonization resistance. It has a direct or indirect influence on adhesion and nonspecific resistance of this system. Studying individ ual variants of the cenotypes and their ecological characteristics in health and disease yielded an estimation algoritm of the oral cavity microbiocenosis.
Journal of Volgograd State Medical University. 2009;6(4):80-83
pages 80-83 views

THE ROLE OF LEPTIN AND NEUROPEPTIDE Y IN PATHOGENESIS OF REPRODUCTIVEDYSFUNCTIONS IN ADOLESCENT GIRLS WITH ANOREXIA NERVOSA

Andreeva V.O., Andreeva V.O.

Abstract

Serum leptin and neuropeptide Y levels have been determined in 2 studied groups of patients and in the control group. A decreased leptin level was found at the anorectic stage, and hyperproduction of leptin was found at the stage of reduction of anorexia nervosa. It was also determined that leptin level is not depend on BMI. Hypoleptinemia of anorectic stage was accompanied by a decreased neuropeptide Y level, which indicates formation of resistance to the low leptin level that may be caused by a disorder of leptin transport through the hematoencephalic barrier and by hypoinsulinemia.
Journal of Volgograd State Medical University. 2009;6(4):84-87
pages 84-87 views

A COMPARATIVE ASSESSMENT OF THE EFFECTIVE THERAPYWITH THE PREPARATION CONTAINING ANTIBODIES TO C-END FRAGMENTOF AT1-RECEPTOR OF ANGIOTENSIN II (CARDOSTAN) AND VALSARTAN (DIOVAN)

Frolova E.V., Frolova E.V.

Abstract

At present the problem of investigation of new ways in treatment of arterial hypertension in combination with metabolic syndrome and search for remedies able to influence on different symptoms of these diseases simultaneously is of great importance. Cardostan regulates rennin-angiotensin-aldosteron system activity decreasing blood pressure, normalizes lipid profile. It isn't inferior in hypotensive effect evidence to diovan treatment in dose of 80 mg a day singly. In addition the influence of diovan on lipid metabolism wasn't revealed.
Journal of Volgograd State Medical University. 2009;6(4):88-90
pages 88-90 views

THE REINFORCEMENT OF RENIN-ANGEOTENSIN-ALDOSTERON SYSTEMBLOCKAGE: COMPARISON OF THE RESULTS OF THE MONOTHERAPYBY CARDOSTEN AND THE COMBINATION OF CARDOSTEN AND ENALAPRILAMONG THE PATIENTS WITH ARTERIAL HYPERTENSION IN COMBINATIONWITH METABOLIC SYNDROME

Frolova E.V., Avdienko A.A., Frolova E.V., Avdienko A.A.

Abstract

We studied the possibility of extra blockage of renin-angeotensin-aldosteron system as a result of combined therapy by ultra small doses of antibodies to C-end fragment of AT-1 receptor of angiotensin II cardosten and angiotensin-converting enzyme inhibitor among patients with the first degree arterial hypertension in combination with metabolic syndrome. The angiotensin-converting enzyme inhibitor enalapril supplement in dose of 10 mg two times a day to the monotherapy by cardosten speeds up and strengthens the hypotensive effect, it favorably influences on the data of lipid and carbohydrate metabolism during first three months of treatment. Further the phenomenon of recession effect develops and the results of treatment aren't different from the monotherapy by cardosten.
Journal of Volgograd State Medical University. 2009;6(4):90-92
pages 90-92 views

NON-MEDICAMENTAL METHODS OF EYE HEMODYNAMICSAND ACCOMMODATION TREATMENT IN MYOPIA PATIENTS

Gndoyan I.A., Petraevskiy A.V., Karadzhe M., Gndoyan I.A., Petrayevsky A.V., Karage M.

Abstract

Study was devoted to comparative investigation of efficiency of non-medicamentous therapy in myopia. The different methods of treatment were estimated in 118 myopic patients of 7-22 years old. To compare positive effect of these methods three main parameters were taken: visual acuity, relative accommodation reserve, anterior ciliary arteries pressure. High efficiency of compound treatment consisting of physiotherapy, training exercises for accommodation and ACA' vasotonic massage arteries was revealed.
Journal of Volgograd State Medical University. 2009;6(4):93-95
pages 93-95 views

NUTRITION OF CHILDREN IN VOLGOGRAD SCHOOLS

Chernova N.V., Chernova N.V.

Abstract

Organization and nature of nutrition of schoolchildren living in the city districts varying in socio-economical and ecological factors and studying at different educational institutions, have been studied. Drawbacks in arrangement and quality of nutrition at schools are exposed.
Journal of Volgograd State Medical University. 2009;6(4):96-98
pages 96-98 views

THE MEDICAL-DEMOGRAPHIC ANALYSIS OF DEATH RATE OF THE TAMBOV'SPOPULATION FROM CRANIOCEREBERAL TRAUMA

Chirkin Y.N., Simonov S.N., Chirkin Y.N., Simonov S.N.

Abstract

Within the framework of complex cliniko-epidemiological research of prevalence of craniocereberal trauma and the organisation of medical aid to the victims we studied death rate and general lethality in craniocereberal trauma. Demographic damage from craniocereberal traumas to the population of Tambov was estimated. We were the first to work out the negative impact of craniocerebral trauma deaths on average life expectancy using the method of plotting lethality tables.It is shown that death rate from the given kind of traumas reduces life expectancy of men by 1,4 years, and women - by 0,55 years; thus the vital potential of population is reduced by 109282 man-years.
Journal of Volgograd State Medical University. 2009;6(4):99-102
pages 99-102 views

INFLUENCE OF THE CHEMICAL SUBSTANCES FROM BIOLOGICAL SAMPLESAND MEDICAL PRODUCT ON RESULTS OF DETERMINATION OF ASCORBIC ACID

Zykova E.V., Zaytsev V.G., Ostrovskiy O.V., Dudchenko G.P., Zykova E.V., Zaitsev V.G., V Ostrovskyiy O., Dudchenko G.P.

Abstract

Ascorbic acid has been measured with organic substances. Monosaccharide and disaccharides lowered results of measurement of an ascorbic acid in substances by 2, 6-dichlorophenol indophenol procedure. Tannins and flavonoids overestimate of measurement of an ascorbic acid by photometric methods. An experimental error of methods of measurement has been found out at presence of organic substances at sample.
Journal of Volgograd State Medical University. 2009;6(4):103-105
pages 103-105 views

ROLE OF LIPOPEROXIDATION ACTIVATION IN PATHOGENESISOF EXPERIMENTAL PLAGUE INTOXICATION

Afanas'eva G.A., Chesnokova N.P., Afanaseva G.A., Chesnokova N.P.

Abstract

Activation of lipid peroxidation increasing during elevation of clinical symptoms of Y. pestis intoxication and hypoxic syndrome development, is the efferent link in cytopathogenic effects of toxic and enzymatic factors of this microorganism. Absolute or relative insufficiency of enzymatic mechanisms of blood antioxidant protection systems is the main pathogenetic factor in lipid components of biomembrane destruction leading to the haemorrhagic syndrome development in Y. pestis intoxication.
Journal of Volgograd State Medical University. 2009;6(4):106-109
pages 106-109 views

LIPOSOME-ENTRAPPED GENTAMICIN AND ITS USE IN TREATMENT OF MELIOIDOSIS

Rotov K.A., Tikhonov S.N., Snatenkov E.A., Alekseev- V.V., Antonov- V.A., Alekseeva- V.V., Savchenko S.S., Kurilov V.Y., Rotov K.A., Tikhonov S.N., Snatenkov E.A., Alekseev V.V., Antonov V.A., Alekseeva V.V., Savchenko S.S., Kurilov V.Y.

Abstract

The data on preparation of liposome-entrapped gentamicin sulfate and their investigation on albino m ice with melioidosis are presented. Comparative study of the efficacy of gentamicin sulfate in free and liposome-entrapped forms showed that immobilization of antibiotics in phospholipids vesicles provided a 3-fold increase of their efficacy.
Journal of Volgograd State Medical University. 2009;6(4):110-113
pages 110-113 views

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