THE PHENE ANALYSIS OF CONNECTIVE TISSUE DYSPLASIA SYNDROMEIN CHILDREN AND THEIR RELATIVES
- Authors: Strel'tsova EV1, Kalmykova A.S.1, Streltsova EV1, Kalmykova AS1
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Affiliations:
- Issue: Vol 7, No 3 (2010)
- Pages: 46-49
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/118158
- ID: 118158
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Abstract
60 families were examined: probands and relatives of I, II and III relation degrees. The family selection was carried out according to the proband (children at the age of 3-6) with the echocardiographic signs of mitral valve prolapse and/or
anomalously located chorda. The results of examination of 360 people (61 -proband, 123 -relatives of the I relation
degree, 172 -relatives of the II relation degree, 4 -relatives of the III relation degree) showed that the hereditary nature of connective tissue dysplasia with prevalence of so-called «maternal effect» was established in most cases. The high
occurence of external mesenchymal signs in children can be explained by the genetic material storage across the generations.
anomalously located chorda. The results of examination of 360 people (61 -proband, 123 -relatives of the I relation
degree, 172 -relatives of the II relation degree, 4 -relatives of the III relation degree) showed that the hereditary nature of connective tissue dysplasia with prevalence of so-called «maternal effect» was established in most cases. The high
occurence of external mesenchymal signs in children can be explained by the genetic material storage across the generations.
About the authors
E V Strel'tsova
Angelina Stanislavovna Kalmykova
Email: kangeline@mail.ru
E V Streltsova
A S Kalmykova
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