Morphological parameters of placenta in cholestatichepatosis of pregnant women as predictors of perinataloutcome

Histological examination of the 50 afterbirths from puerperant women with cholestatic hepatosis was undertaken;
the comparison group comprised 52 patients with gestosis; 50 afterbirths from patients with physiological pregnancy
and noncomplicated delivery constituted the control group. It was established that the main morphological criterion
of placental incompetence in cholestatic hepatosis is obliterating angiopathy. Reduction of capillary flow of terminal villi,
reduced vascular index correlate with worsened condition of the newborns. Administration of complex therapy to patients
with incipient clinical presentations of cholestatic hepatosis and the use of vascular drugs permits improvement of perinatal
outcomes.

cholestatic hepatosis of pregnant women, placenta, obliterating angiopathy, newborn