The role of markers of the epithelial cells renewal and apoptosis in gastric diseasesassociated with H. pylori
- Authors: Osadchuk AM1, Kogan NY.1, Kvetnoy IM1, Osadchuk AM1, Kogan NJ1, Kvetnoy IM1
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Affiliations:
- Issue: Vol 4, No 1 (2007)
- Pages: 30-35
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/139986
- ID: 139986
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Abstract
Рatients with gastric diseases associated with H. pylori were surveyed. All patients are divided into 4
equal groups: patients with chronic atrophic gastritis (CAG), gland polyps, stomach ulcer disease (SUD) and cancer of
stomach (CS). Group of comparison was made up of 12 practically healthy individuals.
It is established that SUD, CAG, gland polyps and CS are consecutive stages of disturbance of renewal of epithelial
cells of gastric mucosa, manifested in a progressing retardation of apoptosis activity from the proliferative process,
which is reflected in increased expression of Ki-67 and Bcl-2. A successful eradication of H. pylori improves the parameters
of cellular renewal. Thus the relation of apoptosis to proliferation of epithelial cells tends to become normal, which allows
us to presuppose a possibility of involution of atrophic, metaplastic and dysplastic changes of a gastric mucosa in
patients with gastric diseases associated with H. pylori.
equal groups: patients with chronic atrophic gastritis (CAG), gland polyps, stomach ulcer disease (SUD) and cancer of
stomach (CS). Group of comparison was made up of 12 practically healthy individuals.
It is established that SUD, CAG, gland polyps and CS are consecutive stages of disturbance of renewal of epithelial
cells of gastric mucosa, manifested in a progressing retardation of apoptosis activity from the proliferative process,
which is reflected in increased expression of Ki-67 and Bcl-2. A successful eradication of H. pylori improves the parameters
of cellular renewal. Thus the relation of apoptosis to proliferation of epithelial cells tends to become normal, which allows
us to presuppose a possibility of involution of atrophic, metaplastic and dysplastic changes of a gastric mucosa in
patients with gastric diseases associated with H. pylori.
Keywords
References
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