Vol 4, No 1 (2007)

The article presents results of pilot study «Patients' attitude to the National project Health». The conclusion is as follows: global sociological monitoring is necessary for explication of the patients' attitudes; a constructive position in the implementation of the project is called for.

We estimated the frequency of occurrence, clinical features of periodontal and gastrointestinal pathology in chronic obstructive lung disease; some mechanisms of their development were investigated.

We carried out a hormonal examination of 69 teenage girls with obesity aged 17-19. The girls with obesity were divided into the following groups: 1 - with hypothalamic syndrome of pubertal period, 2 - with syndrome of polycystic ovaries, 3 - with alimentary-constitutional obesity. The analysis of our findings revealed that obesity decreased reproductive health of teenagers. We determined that in girls with hypothalamic syndrome of the pubertal period and in those with syndrome of polycystic ovaries, hypothalamohypophyseo-adrenal and hypothalamo-hypophyseo-ovarian dysfunction is more pronounced than in girls with alimentaryconstitutional obesity.

The efficiency of transcranial electrostimulation in complex treatment of oral lichen ruber planus was studied. This investigation reveals that in treatment of oral lichen rubber planus transcranial electrostimulation brings psychological and autonomous nervous status to normal. The results obtained prove a sufficient improvement of the indices in psychological tests upon including transcranial electrostimulation into complex treatment of the oral lichen ruber planus. Thus, the use of transcranial electrostimulation makes it possible to improve the efficiency of a complex treatment of the oral lichen ruber planus.

Cytophotometric method was helpful in establishing that such parameters as Kgenfa criterion and the modal class of cells can be used for estimation of functional state of cell population.

Complex clinical and laboratory study of patients with breast cancer was carried out. Results obtained made it possible to reveal general regularities as well as specific features of immune status disturbances and mechanisms of nonspecific resistance in patients with nodal breast cancer (I-IIА and IIВ stages of the disease) and edematousinfiltrative breast cancer (without metastases). The regularities revealed are characterized by CD4 Т-lymphocyte decrease and CD8 Т-lymphocyte increase in the blood. CD8 - Т-lymphocytes correlate with neoplastic histological structure and metastatic process spreading. A considerable disturbance in the correlation of CD4 Т-lymphocytes and CD8 Т-lymphocytes was noted in edematousinfiltrative breast cancer. In case node breast cancer develops, constant and rapid decrease of T-helpers number in blood with simultaneous increase of CD8 Т-lymphocyte percentage is considered to be the most prognostically unfavorable factor as it shows that metastatic process takes place. Neoadjuvant polychemotherapy treatment of patients with nodal breast cancer and edematous-infiltrative breast cancer is accompanied by intensification of free radical oxidation process, destabilization of biologic membranes, development of cytolysis syndrome. The latter factor calls for administration of antihypoxants and antioxidants in complex treatment of oncologic patients; in this way neoadjuvant polychemotherapy treatment can be made more efficient.

The activity of xanthine oxidase, xanthine dehydrogenase and 5'-nucleotidases in lymphocyte lysates and blood plasma was studied in 50 patients with systemic scleroderma upon admission to hospital, after 10-12 days of treatment and on completion of the inpatient care course. Considerable changes of enzyme activity depending on the intensity of pathologic process, the nature of the clinical course and the stage of disease were clearly recognizable. As the activity of the process increased, the enzyme activity reduced in lymphocyte lysate and rose in blood plasma.

Phenibut salt with succine acid in the ratio of 2:1 and phenibut salt with citric acid in the ratio of 3:1 stimulated exercise performance to a greater degree than a compound of phenibut with organic acids in the ratio of 3:3, 3:6, 3:12. It is obvious that the metabolic component induced by the presence of succine and citric acids does not play an essential role in actoprotective action of phenibut salts.

Antioxidant properties of a new compound, coded as RU-1249 containing stericly hindered phenolic group in its structure, as well as reference drugs dibunol and trolox were studied in vitro in concentration of 10 ∝M. It was established that RU-1249 compound showed a very high antioxidant activity (89,2 % inhibition) on the ascorbate-induced lipid peroxidation model, surpassing dibunol (75,9 %) and trolox (61,9 %). While studying the mechanisms of its action, it was shown that RU-1249 compound inhibited lipoperoxyl radical on vitelline lipoprotein chemiluminescent models (79,3 %), second to dibunol (84,1 %) and trolox (84,2 %); it was also shown that RU-1249 compound is an effective interceptor of reactive oxygen forms (74,5 %), which was shown on Fe2+-luminol dependant chemiluminescence, exceeding dibunol (57,1 %) and trolox (61,5 %) in this kind of activity.

Evaluation of the functional condition of liver of the patients with the 1-st and 2-nd type diabetes mellitus (DM) of different severity and duration was undertaken using clinical, biochemical and instrumental methods of investigation. The indices characterizing cytolysis syndrome (97,8 %) and mesenchymo- inflammatory syndrome (80 %), were changed in 1st type DM patients, while in the 2nd type DM patients the indices of cytolysis syndrome (92,3 %) and hepa tocellular insufficiency (76,9 %) were positive. Our observations revealed the involvement of liver into the pathologic process with steatohepatitis developed in both the 1st and 2nd type DM patients.

Dry extract of Glymnema sylvestre is characterized by hypoglycemic activity if compared with diabeton. Its extract lead to an increase in glucose absorption factor by isolated diaphragm in rats. It promoted a decrease in the rate and duration of hyperglycemia in peroral glucose tolerance test. It also increases the volumetric part of pancreatic islets, leading to a moderate hypertrophy of β-endocrinocyte nuclei.

Medicine is a special kind of human activity containing all cultural aspects. Medicine and culture interact in all their aspects promoting qualitative human development.