METABOLIC CHANGES IN ORGANS AND BLOOD UPON ALCOHOLISATION AND EXPERIMENTAL CHRONIC ALCOHOLIC PANCREATITIS


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Abstract

To estimate the involvement of rat liver and myocardium in alcoholisation and experimental alcoholic pancreatitis, we estimated the content of lactate, pyruvate, reduced glutathione and its enzymes as well as superoxide dismutase (SOD) and catalase. The development of alcoholic pancreatitis was accompanied by a rise of antioxidant parameters in the liver and myocardium followed by a depression of catalase activity while SOD and glutathione dependent enzymes were activated. All these parameters increased in the myocardium. Experimental alcoholic pancreatitis involved the liver and myocardium more strongly than the chronic alcohol intake.

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Copyright (c) 2011 Letunovskiy A.V., Mikashinovich Z.I., Letunovsky A.V., Mikashinovich Z.I.

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