HUMAN TELOMERASE REVERSE TRANSCRIPTASE (HTERT) AND ASSOCIATED DISEASES OF UTERUS


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Abstract

hTERT is a rate-limiting determinant of telomerase activity. We have studied the expression of hTERT gene in samples of myoma, of adenomyosis, of simple hyperplasia, of atypical hyperplasia. hTERT gene expression was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) with microglobulin as an indirect marker of tissues integrity. None of theinvestigated samples had any hTERT gene expression. A sample of endometrial cancer was positive for hTERT gene expression.

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Copyright (c) 2009 Adamyan L.V., Gusaeva H.Z., Marchenko I.A.

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