Vol 6, No 1 (2009)

The order of biomedical research, voluntary written informed agreement of the subjects and rights of patients are described. Normative regulation mostly concerns of investigations of medical drugs, but as for other types of biomedical research there is a legal vacuum. It is established that elaboration of new methods of prophylaxis, diagnosis, treatment, rehabilitation, modern medical technologies needs stringent government regulation for guaranteeing of effectiveness and safety of their application in medical practice.

The main problems of cardiotroponins, creatine kinase analysis and their interpretation are described. Cardiotroponin level in 6-24 hours after stenocardia attack is the most informative way of assessing myocardial lesion. Results of this investigation may be used for determination of lethal outcome risks, choice of optimal treatment of ischemic heart disease, estimation of its effectiveness. Increasing troponin level in the blood is the key marker to diagnose non-ST-elevation in myocardial infarction (NSTEMI).

The paper focuses on the result of surgical treatment of 106 patients with uterine myomas using modern technologies. Laparoscopy in conjunction with argon-induced electrocoagulation, ultrasonic scalpel - and radiowave knife have been used for the removal of myomatous nodes. Our clinico-experimental study has confirmed that with radiowave energy, reparative regeneration started in the early stage had a slight inflammatory reaction and minimal coagulation necrosis. Comparative analysis of the surgical energy showed that myomectomy using the radiowave knife turns out to be the least time consuming.

Article presents the results of complex clinical and laboratory examination of 102 newborn with pathology of liver. Author studied the clinical current of liver failure by newborn depending on expression of function-structured breaches. Author suggests the clinic-diagnostic criteria of different degrees gravity of liver failure by newborn as a matter of record.

The influence of workload ofidentical intensity and duration performed in the morning, afternoon and in the evening on the external respiration, gas-energy exchange, thermal state, cardiovascular system, nervous system and physical working capacity of sportsmen was studied. It has been established that the performance of assigned work in the microclimate with optimum conditions of heat transfer is accompanied by an increase in functional over-stress and fatigue of athletes in the evening at the expense of increasing "energy cost" of such work.

It is shown that additional administration of mildronat in basic therapy of diabetic distal symmetric sensorimotor polyneuropathy (DN) with α-lipoic acid produces a beneficial effect on pathogenic modified factors of DN, such as oxidative stress, lipid metabolism. It is accompanied by improvement of the parameters reflecting the degree of severity of diabetic distal symmetric sensorimotor neuropathy.

There have been studied opportunities of ultrasound examination in both bile hypertension diagnostics and the causes ofits development. It has been determined that in 92,4% of cases ultrasound examination makes it possible to diagnose symptoms of bile hypertension. However, variability of the Ultrasound Examination in revealing bile hypertension causes is 72,26%.

The Role of concomitant diseases in the genesis and outcomes of nosocomial pneumonia (NP) is reliably high. The main contribution to the outcome of NP is made by chronic cardiac insufficiency. «Premorbid lifestyle score» can be used as an objective criterion encompassing the patients' premorbid condition as well.

Iron-deficiency anaemia increases the risk of development of chronic foetoplacental insufficiency. Morphological structure of placenta of women with anaemia with different somatotypes aged 19-40 was investigated. Organ- and histostereometrical analysis of placenta has allowed us to reveal compensatory reorganizations in placenta of women with anaemia.

A Total of 82 patients with osteoarthritis were examined. They underwent clinical and laboratory investigations to asses the efficiency of balneologic remedy «Elton» in comparison with local non-steroid antiinflammatory remedy «Fastum-gel». In patients who received Elton clinical parameters were significantly improved like in the group of patients who received «Fastum-gel». In patients who received «Elton» there was revealed a decreased level of antibodies to collagen and antibodies to hyaluronic acid, which proves a decrease in reactive inflammation.

The introvert type is reliably the largest group of all people with the syndrome of cardiac connective tissue dysplasia. They typically demonstrate emotional instability and high personal uneasiness. High frequency of revealing of disorder of emotional sphere in patients with minor anomalies of heart proves that transformation of emotional intensity in psychosomatic frustration (neurosis) is possible on the one hand; on the other, psychological factors influence the risk of development and aggravation of the available cardial pathology.

Clinical features of inflammatory periodontal diseases in patients with peptic ulcer were determined. In pathogenesis of inflammatory periodontal diseases in patients with peptic ulcer the change of quantity of nitric oxide synthase-, endothelin-1-, melatonin-like cells of gingiva and stomach is of great value. Their lesion was more significant in patients with chronic periodontitis and stomach ulcer. The efficiency of eradication therapy depends on degree of periodontal diseases. The greater the degree of inflammatory periodontal diseases in patients with peptic ulcer, the less effective 1-week eradication therapy. Completeness of eradication in patients with peptic ulcer and periodontitis of severe degree is possible only upon increase of treatment to 14 days.

hTERT is a rate-limiting determinant of telomerase activity. We have studied the expression of hTERT gene in samples of myoma, of adenomyosis, of simple hyperplasia, of atypical hyperplasia. hTERT gene expression was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) with microglobulin as an indirect marker of tissues integrity. None of theinvestigated samples had any hTERT gene expression. A sample of endometrial cancer was positive for hTERT gene expression.

The paper presents practical recommendations on diagnostics and prophylaxis of ischemiс stroke. Special emphasis is on early diagnostics.