Vol 9, No 3 (2012)

The paper considers modern aspects of biopharmacy in the process of development, manufacture and administration of medicines. The effect of major biopharmaceutical factors on the quality and efficiency of medicines in traditional and modern medicinal forms is shown on specific examples.

Аccording to the findings of pharmacological studies the mineral bischofite is one of the most promising remedies optimizing cornea reparation. We have investigated the reparative process after a skin injury with administration of bischofite and glycyram ophthalmological spray. The findings indicated a expressed reparative activity of the bischofite and glycyram ophthalmological spray in comparison with Lacrisifi eye drops. It was established that complete epithelization was obtained earlier using bischofite and glycyram ophthalmological spray in comparison with the control group, so these medications can be used as stimulators of cornea reparation after surgery and injury.

We have established that the inulin quantitative order (23,82 ± 0,4%) in Inula helenium rhizome and roots, growing in theVolgograd region, exceeds that of the tuber of Helianthus tuberosus. Thus, Inula helenium rhizome and roots growing in Volgograd region can be used as a promising source of new drugs.

It was established that the substance of hydrachloride of ß-phenylglutamic acid belongs to the class of low-toxic compounds. When introduced intraperitoneally to female mice, its LD 50 forms was 1139,17 (907,16—1430,52) mg/kg (daily) and 746,09 (398,03—1398,51) mg/kg (two-week); when introduced intraperitoneally to male mice — 798,29 (576,49—1105,43) mg/kg (daily) and 684,13 (448,75—1042,98) mg/kg (two-week); to female rats — 950,22 (846,26—1066,95) mg/kg (daily) and 724.13 (581,82—901,25) mg/kg (two-week), to male rats — 1029,04 (892,12—1186,98) mg/kg (daily) and 747,10 (563,80— 989.99) mg/kg (two-week). In the intoxication pattern the following CNS deprivation effects were noted: sedation, muscular hypotonia, hyporeflexia without any essential effect on the respiratory rate.

Prenosological diagnosis of pain syndrome is one of the most important problems of modern vertebroneurology. Diagnosis should be expressive, non-invasive, well-founded. The paper presents new diagnostic approaches to determining the causes of pain syndrome development.

A vasotonometer for blood pressure measurement in the anterior ciliary ocular vessels (arteries and veins) was developed. All the requirements for contemporary diagnostic equipment were observed. The advantages of the proposed device are the wide range of the measuring values (from 0 to 120 mm Hg) and high precision (error range ±1 mm Hg). The device is gated to PC, which allows a convenient user interface and patients data base.

We have studied the organization and working conditions of workers of the basic professional groups at large baking enterprises. A need to develop and implement a complex of hygienic measures optimizing the technological process, working conditions and the mode of work of working women is substantiated.

Results of clinical and laboratory study of 100 newborns receiving respiratory support are proposed. The gas composition of capillary blood was estimated. The nosotropic variants of acute respiratory insufficiency of newborn on artificial lung ventilation are presented.

The outcome of Helicobacter pylori infection management in senior patients is often evaluated as unsatisfactory. That is why determination of prognostic factors of effectiveness of anti-helicobacter therapy in such patients seems plausible. We studied prognostic factors determining the effectiveness of Helicobacter pylori elimination and revealed poor patients' compliance with therapy requirements, antibiotic resistance, smoking, alcohol abuse, imbalanced diet.

Using the methods of time series analysis we studied the dynamics and relationship with the extent of alcohol consumption in cancer of trachea, bronchus and lung mortality in the Arkhangelsk, Vologda, Murmansk region. We revealed a significant association between the indicator of alcohol consumption and mortality in male populations.

This article discusses present-day approaches to surgical treatment of lumbar spine degenerative disease using dynamic stabilization systems.

We performed an assessment of uterine tubal patency in tuboperitoneal infertility using a high-tech imaging method: computerized multispiral salpingography This method of visualizing uterine tubes in diagnostics of infertility allows a confirmation of both uterine occlusion and the nature of pelvic pathological process. The method does not require the patient to be admitted to hospital; it produces no complications.

As a result of a complex study of pharmacological effects of sodium desoxyribonucleate, cytoprotector and immunomodulator, in animals with cerebral flow disorder and streprozocin diabetes mellitus it was established that upon course administration the drug restores the automation of nomotropic pacemaker, conduction in the atria and atrioventricular plexus, adiaphoria of atrioventricular plexus damaged due to acute cerebral ischemia. Sodium desoxyribonucleate does not suppress the inotropism of feline heart and limits the size of necrotic zone in rats with myocardialinfarction accompanying cerebral flow deficiency and diabetes mellitus.

Fetal nuchal translucency (NT) thickness was evaluated in 34 fetuses in the first trimester. This was a retrospective study using stored values of the head volume from normal fetuses at 11—14 weeks. Two experienced operators each measured the NT thickness, twice manually and twice using the semi-automated software. The intraoperator SD for manual measurements was 0,144 mm for Operator 1 and 0,162 mm for Operator 2, and for semi-automated measurements it was 0,034 mm for Operator 1 and 0.051 mm for Operator 2. NT thickness can be assessed reliably using the semi-automated algorithm, which allows standardization of the NT assessment process.

On the basis of an analysis of emotional burnout preconditions among specialists of helping professions of the health system we developed the structure and content of a program of its psychological prevention in the process of continuous professional education.

Complex diagnostics of back pain revealed a high prevalence of subjective and objective respiratory dysfunction. As a result of an analysis, close intersystem and intrasystem interrelations were established, especially between the respiratory and motor parameters.

Calculation of the demand for narcotic drugs and psychotropic substances is an important stage in setting up a coordinated system that ensures conformity between the quantities of the medicines available, and health needs. The article presents approaches to the calculation of the needs for narcotic drugs and psychotropic substances for therapeutic purposes.