Vol 6, No 3 (2009)

The lecture is devoted to ethiopothogenesis, diagnostics and treatment of nonalcoholic fatty liver disease. Authors emphasize evidence-based treatment and prognosis.

The method of surgical treatment of skin tumours and side-effects of radiation therapy of skin tumours of extremities consists in plastic restoration of postoperative defects using a complex of adjacent tissues, taking into account angioarchitectural peculiarities of the donor skin. Grafts vascularized with perforant vessels possess high vitality and reliability, identical in colour and skin texture to recipient zone. Immediate proximity to perceiving zone contributes to minimal deformation of donor area. Using the method of plasty with dermatofascial grafts on perforant vessels in treatment of malignant skin tumours and late radiation complications in the working group of the patients did not aggravate remote results of treatment, considerably improving immediate results. The method contributes to performing more radical surgery operations at the same time decreasing the risk of postoperative complications, and improving medical and social rehabilitation of patients.

On the basis of results of research of dynamics of change of relative viscosity of water solutions o f some highmolecular compounds with izoniazid and rifampicin we substantiated a possibility of using a method of viscosimetry for forecasting of bioavailability of medicinal substances. The expediency of using pectin, MS, NaKMS as optimum fillers for development of solid combined medicinal products izoniazid and rifampicin is shown.

We have studied the values of life quality of 114 «highly qualified» sportsmen (1st Grade, Master of Sports Candidates and Masters of Sports). Among these, there were 57 ex-sportsmen and 57 active sportsmen engaged in game sports. The 5 year period after the career termination was indicated as an early period. The research was carried out by means of a standardized non-specific questionnaire SF-36 (the MOS 36-Item Short-Form Health Survey), designated for evaluation of health state irrespective of a certain nosology.

Five compounds (VMA-03-01, VMA-01-21, VMA-99-56, VMA-99-82, VMA-00-29) were evaluated for their in vitro and in vivo immune-modulating effects. VMA-03-01, VMA-01-21, VMA-99-56 have been shown to increase phagocytosis and microbicidal activity in human neutrophils, thus affecting innate immunity. All compounds affect early and late stages of T cell activation, which is shown by measurement of CD69- and CD25- T cells. In the rat model, compounds VMA-03-01 and VMA-01-21 inhibit specific antibody production.

A new scheme of muscle procedures in children strabismus surgery was proposed. 352 children (352 eyes) with esotropia were operated according to this scheme. 342 children (342 eyes) with esotropia (control group) were operated according to Avetisov-Machkamova scheme (1966). Orthotropia was achieved in 83,8 % cases of the studied group and 41,7 % cases of control group. Secondary exotropia occurred in 1.2 % of research group and 1.1 % cases of control group.

The results of treatment of 95 patients were analyzed. The criteria of disturbances of mesenteric circulation were singled out on the basis of the analysis. The systemic approach permitted a development of diagnostic algorithm in the scale mode. Obvious signs of ischemia require surgery. Administration of a complex of non-specific m easures was substantiated for improvement of circulation indices and rheologic blood indices.

The paper studies the possibility of using skin excretion as biomaterial for quantification of urea content. The study experimentally selected optimum conditions for skin excretion sampling by way of application.

We studied the rate of occurrence of arterial hypertension and other risk factors of cardiovascular diseases in young people. Individuals with normal and optimal arterial pressure were established to have a less marked risk factor. Compared with girls young men were observed to smoke, to have excessive body weight and elevated arterial pressure.

The paper offers a comparative analysis of perindopril and enalapril effect on clinical and laboratory findings in patients with hypertension complicated by acute lesion of cerebral circulation

Coarctation of aorta in infants combines with systemic congenital cardiac and vascular diseases in 67,5 % of cases. There are morphological peculiarities in the structure of different parts of aorta with coarctation.

Statistically authentic possibilities of a computer tomography (КТ) in diagnostics of focal lesions of liver are defined. КТ it is high-sensitivity in various local defects of a liver and allows to exclude people without diseases. The posttest probability of positive result of research is very high.

The paper presents the results of a comparative study of anthropometric and functional parameters of adolescents aged 13-16, of both sexes, from different ethnic backgrounds, residents of the Republic of Kalmykia. It is established that at the present time physical parameters of adolescents aged 13-16 such as body weight, height, chest circumference exceed the above-mentioned parameters registered in 1965 in groups of the same age, sex and ethnic-territorial origin.

Factor analysis is using for examining different phenomenon, including medical care quality. For making medical care analysis it is necessary to take into consideration such factors as: cadres reserve, finance reserve, hardware, efficacy of the technology. SWOT-analysis technology separate all characteristics into 4 factors: strengths, weakness, opportunities, threats. SWOT-analysis is effective because it includes organization position and characterizes influence of the extraneous factors.

By the spent research it is shown, that the general tendencies of occurrence and development by myocardial infarction for last 30 years have not undergone essential changes. Reduction of number of thromboses from 50 to 30 % can be caused occurrence of more effective antiaggregant drugs and application modern thrombolytics both at stages of rendering of the urgent help, and at treatment acute myocardial infarction. To macroscopic establish borders of a myocardial infarction till 72 o'clock from the beginning of its development it is difficult enough, for pathological processes progress, and the heart attack zone extends.

The review presents modern views on diagnostics and treatment of pancreonecrosis. Characteristics and assessment of efficiency of the basic methods of surgical treatment of pancreonecrosis and its complications is presented.