Comparison of cytokine-inducing Activity of Different Types of Burkholderia's Antigens
- Authors: Proshina OB1, Zukova SI1, Piven NN1, Khrapova NP1, Avrorova IV1, Drefs NM1
-
Affiliations:
- Issue: Vol 3, No 2 (2006)
- Pages: 44-46
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/117809
- ID: 117809
Cite item
Full Text
Abstract
The purpose of this work was to study the cytokinе-inducing activity of antigens of the melioidosis agent (Burkholderia pseudomallei) and its nonpathogenic type (Burkholderia thailandensis). In experiments in vitro on BALB/c mice macrophages and lymphocytes induced by water-salt extracts of Burkholdeias the activity of lymphokines and monokines was studied. The interrelation between the protective properties of Burkholderia's antigens and some parameters of its cytokin-inducing activity (the level of expression of Fc-receptors on neutrophils, phagocytic activity of macrophages and cytotoxic activity of TNF-α for mice fibroblasts L-929) was shown.
Keywords
References
- Васильева Г.И., Иванова И.А., Беспалова И.А. и др. // Журн. микробиол., эпидемиол. и иммунобиол. -2002. - № 3. - С. 39-45.
- Любимов Г.Ю., Зенков Н.К., Вольский Н.Н. и др. // Иммунология. - 1992. - № 1. - С. 40-43.
- Barnes J.L., Ulett G.C., Retheesan N., et al. // Immunol. Cell Biol. - 2001. - Vol. 79. - P. 490-501.
- Simpson A.J., Smith M.D., Weverling G.Y., et al. // J. Infect. Dis. - 2000. - Vol. 181(2). - P. 621-625.
- Stephens D.P., Fisher D.A., Currie B.J. // Intern. Med. J. - 2002. - Vol. 32. - № 4. - P. 143-148.