Том 2, № 4 (2005)

Pharmacoepidemology and pharmacoeconomics are described as new trends in evidence-based medicine. They aim at developing optimal treatment patterns based on their cost, efficiency and life quality importance. Their application will result in both decreased loss of work ability and all kinds of costs.

Методами теоретического конфирмационного анализа изучено трехмерное строение пептида FMRFa (Phe-Met-Arg-Phe-амида), лиганда протон-чувствительных ионных каналов. На основании этих данных предложена структура соединений, способных ингибироватъ эти ионные каналы. Синтез ряда дизамещенных производных аргигинина и оценка их биологических свойств на изолированных нейронах спиналъных и тригеминальных ганглиев крыс позволило сделать определенные выводы о связи химической структуры с биологической активностью в этом ряду и высказать предположение о различии механизмов влияния соединений на пиковую амплитуду тока и на десенситизацию.

More than 80% of the yong swimmers develop disadaptation syndrome during intensive training manifested by the deviations of the biochemical parameters in blood and urine. This condition requires certain correction and development of preventive strategies.

The influence of long therapy with mildronat on the quality of life and morphofunctional parameters of the heart was studied in the remote period in the sick people with chronical cardiac insufficiency (CCI) developed after the suffered myocardial infaction. The application of mildronat in the complex therapy of CCI has led to the improvement of CCI course: functional class has increased, the dynamics of basic morphofunctional parameters of the heart has been seen, systolic function of myocardium has improved. At the same time normalization of physchphysiological status and considerable improvement quality of life of these people has been observed.

After screening the animals with high (HR group) and low (LR) nonspecific reactivity level hypothalamic suprachiasmatic nuclei were studied in details. It was established for these nuclei in rats of HR group to have more dense and homogenous neuronal structure, low glial cell/neuron ratio, and prevalence of neuron associations near dorsoventral margin of nucleus. These findings were connected to variety of systemic reactions of HR and LR animals in chronic stress.

The paper describes the pattern of treating patients with rheumatoid arthritis and seronegative spondylarthritis with the new drug of Arthrofon.

Nowadays a medical interview is believed to be something more than mere case history taking. It is an interactive process and requires a number of communication skills. Development of these skills will not only maximize the amount of correct clinically important information but also increase therapeutic compliance and lead to better clinical out-comes.