Effect of ultralow temperatures on tumour-like lesionsof bones

The effect of ultralow temperatures on the structure of fibrous dysplasia, metaphyseal fibrous defect,
bone cysts is investigated. Fragments of this newgrowth, obtained from 29 patients, were exposed to instillation and contact
cryotherapy. The temperature of tissue processed varied from -42 to -134 ºС. The achieved destruction and devitalisation
of pathological tissue was estimated by morphometrical calculation of the amount of killed elements. There was
impairment of cell membranes and stroma of connective tissue. The count of destroyed cellular elements of the cyst
membranes varied from 20 up to 60 % upon contact cryotherapy and instillation processing with nitrogen. Necrosis of
cells of fibroblastic leneage was up to 40 % upon contact cryotherapy and up to 30-35 % upon instillation cryotherapy.
The obtained data make it possible to increase the destruction of tumor cells upon resection of tumour-like lesions of
bones. Cryodestruction and resection of bone excludes excessive radical surgery.

cryodestruction, bone cysts, fibrous dysplasia, metaphyseal fibrous defect