PODKhODY K TERAPII REFRAKTERNYKh FORM RASSEYaNNOGO SKLEROZA U DETEY


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Abstract

Currently, number of drugs for the traditional long-term therapy for multiple sclerosis (MS) in adults is registered. Published data from international retrospective studies indicate a good tolerability and safety of interferon-β in children and adolescents with MS. But in childhood, pernicious course of MS often occurs, which is characterized by not only resistance to corticosteroids, but also to immunomodulatory drugs. There is need for a detailed analysis of the risks and benefits of alternative ways to treat MS, when the 1st and sometimes 2nd lines drugs are ineffective. In these settings, one of the most promising directions in MS therapy in children is the use of cellular technology and immunosuppressive drugs in high doses for the achievement of long-term remission of MS.

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