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编号 10 (2014)
- 年: 2014
- 文章: 11
- URL: https://journals.eco-vector.com/2073-4034/issue/view/6874
Articles
Sovremennye podkhody k farmakoterapii bolezni Parkinsona: terapiya motornykh simptomov - gipokineziya, rigidnost' i tremor
摘要
The paper presents the main ways for the treatment of patients with Parkinson's disease. Particular attention is paid to the modern approaches to pharmacotherapy of motor symptoms - hypokinesia, rigidity and tremor, as a crucial for this disease. Substitution (symptomatic) therapy promotes restoration of dopamine deficiency in the brain, and thereby improves the functional state of the patients. The results of international studies of pharmacotherapy of motor symptoms are presented, and different therapeutic strategies are considered.
Pharmateca. 2014;(10):8-11
8-11
Narusheniya sna pri bolezni Parkinsona
摘要
Disorders of sleep of and wakefulness are one of the important problems in the treatment of patients with Parkinson's disease. They can be caused by increased symptoms of Parkinson's disease in the evening and at night, use of antiparkinsonian agents, anxiety, depression, or use of some antidepressants, sudden withdrawal from benzodiazepines and other sedatives. In addition, a sleep disorders can be associated with the spread of the process of neurodegeneration on the various structures of the brain stem. Understanding the causes of sleep disorders allows to successfully resolve this problem.
Pharmateca. 2014;(10):12-19
12-19
Voprosy kliniki i farmakologicheskoy terapii bipolyarnogo affektivnogo rasstroystva
摘要
Bipolar affective disorder (BAD) is a severe chronic mental disorder with different phases that requires a comprehensive approach to treatment, depending on the current phase, stage of therapy and clinical characteristics of the state. The review article describes the current approaches to the treatment of BAD at various stages (active, supporting and preventive therapy). Therapeutic schemes for treatment of depressive, manic, and mixed phases are presented. The features of administration and potentials for the combination of drugs of different pharmacological groups - mood stabilizers, antidepressants, antipsychotics, atypical antipsychotics as monotherapy and combined therapy of BAD - are analyzed.
Pharmateca. 2014;(10):20-31
20-31
Sindrom funktsional'noy dispepsii i komorbidnye psikhicheskie rasstroystva
摘要
The article considers the modern views on the etiopathogenic and clinical content of syndrome of functional dyspepsia; the results of own author’s observations (clinical experience of psychiatrist and gastroenterologist) with respect to clinic course and diagnostics of functional dyspepsia and comorbid mental disorders are discussed.
Pharmateca. 2014;(10):32-35
32-35
Astenicheskie i depressivnye rasstroystva u patsientov pozhilogo vozrasta v ambulatornoy praktike (differentsial'naya diagnostika i terapiya)
摘要
The article discusses the various diagnostic and therapeutic aspects of some mental disorders in elderly patients, which are encountered in outpatient daily practice (therapeutics, neurologists). Such mental disorders as asthenic syndrome, depression, dementia with signs of cognitive deficits that further complicates the differential diagnostic search for non-psychiatric specialists are considered. Some approaches to the treatment of these conditions are discussed, drugs used for this purpose are presented.
Pharmateca. 2014;(10):36-40
36-40
Faktory, vliyayushchie na priverzhennost' bol'nykh k lecheniyu pri bolezni Parkinsona
摘要
Adherence to the treatment in patients with Parkinson's disease (PD) significantly affects the control of the main symptoms of the disease, the number of decompensation, falls and motor fluctuations. Violations of the adherence to the treatment include the use of incorrect doses of drugs, taking them in the incorrect time, missing the use of drug, the abolition of drug, and the use of more than the recommended amount of the drug. One of the manifestations of poor adherence to therapy in PD is dopamine dysregulation syndrome with the development of behavioral disorders. Objective and subjective methods of assessing adherence to treatment of PD patients show contradicting results. Simplification of the regimen of use of antiparkinsonian agents, and appointment of long-acting drugs once a day are a constructive approach to the improvement of adherence to the treatment in PD patients.
Pharmateca. 2014;(10):41-44
41-44
Prognosticheskaya rol' kliniko-sotsial'nykh faktorov v otsenke effektivnosti farmakoterapii u bol'nykh s nepsikhoticheskimi depressiyami
摘要
This article provides a comprehensive analysis of the effectiveness of different options of timoanaleptic therapy. Identified sociodemographic and clinical characteristics of patients who achieved remission and suboptimal responses (response, partial response and non-response), will allow to predict the of efficacy at the stage of treatment planning and optimize provided treatment at early stages.
Pharmateca. 2014;(10):45-52
45-52
Maskirovannye depressii v nevrologicheskoy praktike. Popytka bespristrastnogo analiza
Pharmateca. 2014;(10):53-57
53-57
Levodopa-indutsirovannye diskinezii pri bolezni Parkinsona:patogenez, klinika, podkhody k lecheniyu
摘要
Correction of levodopa-induced dyskinesias (LID) in the treatment of Parkinson's disease is a fairly complex clinical problem, which involves a variety of approaches to a solution. Based on data from clinical trials, article analyzes the experience of LID correction. As a rule, dyskinesia appears on stage of clinical manifestations and often coincides with the moment of increasing doses of levodopa. Reducing the dose of levodopa, however, is not always possible because patients prefer to have soft dyskinesia instead of reduction of locomotor activity. Increased severity or duration of involuntary movements significantly affects the quality of life of patients. It is important to identify the presence of hyperkinesias in patients and assign antidyskinetic drugs as early as possible.
Pharmateca. 2014;(10):58-69
58-69
Perspektivy ispol'zovaniya preparata Tserebrum kompozitum N v terapii psikhicheskikh zabolevaniy (analiticheskiy obzor)
摘要
The review presents the prospects of implementing of antihomotoxical therapy in the treatment of a number of problematic conditions related to the field of psychiatry. Based on the literature data and the results of own research, the author identifies Cerebrum compositum N as the most important antihomotoxical drug for the treatment of psychiatric diseases. Such therapy may be used as a base in the treatment of mental illness of toxic, traumatic, atherosclerotic, and vascular origin. The most curable syndromes include asthenia, cerebroasthenia, anxiety and intellectual-mnestic syndrome.
Pharmateca. 2014;(10):70-73
70-73
Primenenie olanzapina, obshchie i prakticheskie aspekty
摘要
Olanzapine is a modern atypical antipsychotic drug, which is high effective in the treatment of productive and negative mental disorders, has no extrapyramidal side effects, and can suppress further progression of the disease. Due to a wide range of psychotropic activity and good tolerability, olanzapine is the drug of choice in the treatment of various mental disorders. Nevertheless, it is important to take into account a number of features of this drug. General practitioners can be faced with specific symptoms associated with the use of olanzapine; in this regard, they must have sufficient information for a correct interpretation of the various features of the patient’s state.
Pharmateca. 2014;(10):74-79
74-79