No 1S (2015)

The article discusses in detail the principles of rational choice of antimicrobials in dermatovenerology, its objectives and risk factors. The data on the effectiveness of macrolides are presented. Particular attention is paid to roxithromycin (Esparoxy), which combines a wide spectrum of antimicrobial activity, good pharmacokinetic properties, favorable tolerability profile and usability. The results of clinical trials indicating high efficacy and safety of drug in bacterial infections of various localization, including urogenital tract and skin, are presented. The article considers data on health-care action of Balzamed preparations, actively restoring the barrier function of the skin and preventing the development of infectious complications.

Treatment of atopic dermatitis (AD) is based on arresting two cardinal signs of the disease - dryness and itching of the skin. For this purpose, patients requires routinely use of emollients and topical anti-inflammatory drugs - corticosteroids and/or calcineurin inhibitors. However, there are studies strongly supporting the presence of subclinical inflammation, accompanied by disturbances of skin barrier function, cytokine production and lymphocyte infiltration. The new strategy of therapy - proactive therapy - is aimed to achieving control and maintenance of remission of atopic dermatitis. This will allow to achieve control of AD faster and to reduce the risk of recurrence of the disease.

The article highlights the issues of prevalence of allergic conjunctivitis (AC); the current classification of AC according to the form, mechanisms of development, severity and stage of the course is presented. The clinical manifestations of the disease are discussed in detail. Modern methods of diagnosis and differential diagnosis of different clinical forms of eye diseases are considered. Modern principles of therapy and prevention of AC are presented. The main types of therapy AC include non-pharmacological treatment, pharmacotherapy, and allergen-specific immunotherapy. Among the pharmacological treatments, antimediator drugs are widely used, primarily H 1-receptor antagonists, as well as mast cell stabilizers, and anti-inflammatory agents - cromoglicic acid and glucocorticosteroids.

The article presents the results of evalution of the effects of combined cytostatic therapy and sulodexide on the course of dermatosis and indicators of endothelial dysfunction in 125 patients with psoriasis taking into account comorbid conditions. Before therapy in psoriatic patients significant decrease in nitric oxide and increased endothelin-1 and vascular endothelial growth factor in serum were revealed. Among patients who received cytotoxic therapy, the normalization of these parameters was not observed; in patients who received adjuvant therapy with sulodexide, there was a trend to increased levels of nitric oxide, a decrease in the content of endothelin-1 and vascular endothelial growth factor. Thus, the inclusion of sulodexide in the treatment of patients with psoriasis leads to a more rapid regression of cutaneous process and normalization of vascular component of the pathogenesis of dermatosis.

The article presents the results of evaluation of the effectiveness of the drug Belara (Ethinylestradiol+Chlormadinone) in combination therapy of patients with papulopustular acne. Efficacy was evaluated according to the data of clinical, functional and ultrasonographic diagnostics of skin condition. Based on the assessment of the dynamics of morphological changes of the skin by confocal microscopy in vivo, positive structural changes of the dermal collagen matrix during therapy were revealed.