HORMONE THERAPY OF EPILEPTIC SYNDROMES WITH PROLONGED SPIKE-WAVE ACTIVITY DURING SLEEP
- Авторлар: Shidlovskaya O.A1, Belousova E.D1
-
Мекемелер:
- FSBEI HE RNSMU n.a. N.I. Pirogov of RMH
- Шығарылым: № 4S (2016)
- Беттер: 19-23
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289720
- ID: 289720
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Currently, hormone therapy of epileptic syndromes with prolonged spike-wave activity during sleep is a promising developing area in epileptology. Some clinical studies and global meta-analyzes inevitably confirm efficacy of hormones when success can not be achieved using anti-epileptic drugs. However, unified approaches to the choice of the drug and schemes of its administration are not been developed until now. This article discusses the possible mechanisms of action of steroids. Indications for hormonal treatment, data on efficacy and tolerability are presented. Based on own author’s experience, protocol of differentiated tactics of hormonal treatment of epileptic syndromes with prolonged spike-wave activity during sleep is suggested. The chosen strategy allows to achieve a positive effect in reducing the number of seizures and prevent the development of severe neurocognitive deficits in 70-80% of patients.
Негізгі сөздер
Толық мәтін
Авторлар туралы
O. Shidlovskaya
FSBEI HE RNSMU n.a. N.I. Pirogov of RMH
Email: shidlovsckaya.oa@yandex.ru
Neurologist, Department of Psychoneurology and Epileptology SRCI of Pediatrics n.a. Yu.E. Veltischev Moscow
E. Belousova
FSBEI HE RNSMU n.a. N.I. Pirogov of RMHDepartment of Psychoneurology and Epileptology SRCI of Pediatrics n.a. Yu.E. Veltischev Moscow
Әдебиет тізімі
- Berg A.T., Berkovic S.F., Brodie M.J. Buchhalter J., Cross J.H., van Emde Boas W., Engel J., French J., Glauser T.A., Mathern G.W., Moshé S.L., Nordli D., Plouin P., Scheffer I.E. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-85.
- Kramer U., Sagi L., Goldberg-Stern H., Zelnik N., Nissenkorn A., Ben-Zeev B. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia. 2009;50:1517-24.
- Van den Munckhof B., Van Dee V., Sagi L., Caraballo R.H., Veggiotti P., Liukkonen E., Loddenkemper T., Sanchez Fernândez I., Buzatu M., Bulteau C., Braun K.P., Jansen F.E. Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases. Epilepsia. 2015;56(11):1738-46.
- Marchi N., Granata T., Freri E., Ciusani E., Ragona F., Puvenna V., Teng Q., Alexopolous A., Janigro D. Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population одним из препаратов выбора для длительной терапии синдромов с ESES/ CSWS является метилпреднизолон.
- ГТ должна иметь длительный характер (не менее 6 месяцев). В отсутствие положительного эффекта через 3 месяца терапии необходимо прибегнуть к смене препарата (на другой ГКС).
- Строгая профилактика развития побочных эффектов ГТ может позволить минимизировать их частоту.
- После завершения гормонального лечения пациент в течение не менее 6 месяцев должен находиться под наблюдением невролога с регулярным проведением ЭЭГ сна и нейропсихологического тестирования. prospective study of dexamethasone therapy in refractory epileptic encephalopathy with continuous spike-and-wave during sleep. Epilepsy Behav. 2016;55:1-5.
- Bast T., Richter S., Ebinger F., Rating D., Wiemer-Kruel A., Schubert-Bast S. Efficacy and tolerability of methylprednisolone pulse therapy in childhood epilepsies other than infantile spasms. Neuropediatrics. 2014;45(6):378-85.
- Buzatu M., Bulteau C., Altuzarra C., Dulac O., Van Bogaert P. Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep. Epilepsia. 2009;50(7):68-72.
- Inutsuka M., Kobayashi K., Oka M., Hattori J., Ohtsuka Y. Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain Dev. 2006;28(5): 281-86.
- Sinclair D.B., Snyder T.J. Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep. Pediatr. Neurol. 2005;32(5):300-6.
Қосымша файлдар
