RENAL FUCNTIONAL STATE AND HAEMODYNAMICS IN CHILDREN WITH GENETIC-BASED THROMBOPHILIA
- Authors: Shumikhina MV1, Chugunova OL1, Kozlovskaya NL1
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Affiliations:
- Issue: No 6 (2010)
- Pages: 57-60
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245966
- ID: 245966
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Abstract
Aim. Assessment of risk of development and determination of approaches of early diagnosing of kidney involvement in children with hereditary thrombophilia.
Methods. 2 group of children were included into the study: 1st (n=36) - healthy carriers of thrombophilia genes, 2nd - 17 children with hereditary thrombophilia and acute thrombotic event in the anamnesis. Beyond clinical investigation, in all children coagulologic parameters were assessed and ultrasound Doppler scanning of kidneys was performed.
Results. In all children parameters of kidney function were within normal ranges. In 4 children elevation of serum lipoprotein A level was detected; all they had utrasound signs of kidney infarction.
Conclusion. In children with hyperlipoproteinemia renal ultrasound study can reveal changes in intrarenal haemodynamics and renal infacrction.
Methods. 2 group of children were included into the study: 1st (n=36) - healthy carriers of thrombophilia genes, 2nd - 17 children with hereditary thrombophilia and acute thrombotic event in the anamnesis. Beyond clinical investigation, in all children coagulologic parameters were assessed and ultrasound Doppler scanning of kidneys was performed.
Results. In all children parameters of kidney function were within normal ranges. In 4 children elevation of serum lipoprotein A level was detected; all they had utrasound signs of kidney infarction.
Conclusion. In children with hyperlipoproteinemia renal ultrasound study can reveal changes in intrarenal haemodynamics and renal infacrction.
References
- Zangari M., Elice F., Tricot G. et al. Thrombophilia. Drug Target Insights. 2008; 3: 87-97
- Raffini L., Thornburg C. Testing children for inherited thrombophilia: more questions than answers. Br. J. Haematol. 2009; 147(3): 277-288
- Kwan B., Kronenberg F., Beddhu S., Cheung A. Metabolism and lipid management in chronic kidney disease. J. Am. Soc. Nephrol. 2007; 18(4): 1246-1261
- Loscalzo J., Weinfeld M., Fless G.M. et al. Lipoprotein(a), fibrin binding, and plasminogen activation. Arteriosclerosis. 1990; 10: 240-245
- Staples J., Taylor P., Magil A. et al. Progressive kidney disease in three sisters with elevated lipoprotein(a). Nephrol. Dial. Transplant. 2008; 23: 1756-1759
- Young G., Albisetti M., Bonduel M. et al. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Circulation. 2008; 23: 118(13): 1373-1382.
- Cabral Ribeiro J., Sousa L., Calaza C., Santos A. Acute segmental renal infarction due to factor V Leiden. Arch Esp. Urol. 2009; 62(6): 486-488
- Кирсанова Т.В., Козловская Н.Л., Кушнир В.В. и др. Ультразвуковая допплерография почечных сосудов в диагностике поражения почек при тромботических микроангиопатиях. Нефрология и диализ. 2008; 10 (3-4): 219-225
- Gofort R.L., Rennke H., Sethi S. Renal vascular sclerosis is associated with inherited thrombophilias. Kidney Int. 2006; 70(4): 743-750
- Чугунова О.Л., Веpбицкий В.И., Таболин В.А. и др. Инфаркты почек у новорожденных детей. Российский педиатрический журнал 2001; 3: 10-14
- Козловская Н.Л., Боброва Л.А. Генетическая тромбофилия и почки. Клиническая нефрология. 2009; 3: 23-34.
- Jung B.W., Kim S.H., Moon M.H. Imaging features of gray-scale and contrast-enhanced color Doppler US for the differentiation of transient renal arterial ischemia and arterial infarction. Korean J Radiol. 2005; 6(3): 179-184
- Ichihara M., Sasaki K., Umemura S-I. et al. Blood flow occlusion via ultrasound image-guided high intensity focused ultrasound and its effect on tissue perfusion. Ultrasound in Med. & Biol. 2007; 33(3): 452-459
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