Changes of blood haemorheological parameters in lupus nephritis
- Authors: Georginova OA1, Krasnova TN1, Sokolova IA1, Rykova SY.1
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- Issue: No 6 (2010)
- Pages: 69-72
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245986
- ID: 245986
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Abstract
Aim. Assessment of blood haemorrheology disturbances in patients with lupus nephritis. Methods. 41 patients (8 male, mean age 40±14 years, and 33 female, mean age 37±12 years) with systemic lupus erythematosus were included into the study, 30 of the had lupus nephritis. Patients were divided into 3 groups - with non-active lupus nephritis, with lupus nephritis with proteinuria/haematuria, and with active lupus nephritis and nephritic syndrome. Patients with active lupus nephritis were subdivided into subgroup with less prominent (<1000 erythrocytes/ml) haematuria and with high-grade (>1000 erythrocytes/ml) haematuria. 26 healthy subjects in comparable age served as controls. In venous blood kinetics of spontaneous erythrocyte aggregation and desegregation, as well as erythrocyte deformity were determined.
Results. Increase in blood viscosity, decrease of erythrocyte deformity, acceleration of erythrocyte aggregation and increase in erythrocyte aggregates size were detected. In patients with active lupus nephritis time of erythrocyte aggregation, size and durability of erythrocyte aggregates, erythrocyte deformity were minimal. In active lupus nephritis with high-grade haematuria size of erythrocyte aggregates was maximal.
Conclusion. Haemorheology disturbances in lupus nephritis increase simultaneously with the disease activity.
Results. Increase in blood viscosity, decrease of erythrocyte deformity, acceleration of erythrocyte aggregation and increase in erythrocyte aggregates size were detected. In patients with active lupus nephritis time of erythrocyte aggregation, size and durability of erythrocyte aggregates, erythrocyte deformity were minimal. In active lupus nephritis with high-grade haematuria size of erythrocyte aggregates was maximal.
Conclusion. Haemorheology disturbances in lupus nephritis increase simultaneously with the disease activity.
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References
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