Changes of blood haemorheological parameters in lupus nephritis


Cite item

Full Text

Abstract

Aim. Assessment of blood haemorrheology disturbances in patients with lupus nephritis. Methods. 41 patients (8 male, mean age 40±14 years, and 33 female, mean age 37±12 years) with systemic lupus erythematosus were included into the study, 30 of the had lupus nephritis. Patients were divided into 3 groups - with non-active lupus nephritis, with lupus nephritis with proteinuria/haematuria, and with active lupus nephritis and nephritic syndrome. Patients with active lupus nephritis were subdivided into subgroup with less prominent (<1000 erythrocytes/ml) haematuria and with high-grade (>1000 erythrocytes/ml) haematuria. 26 healthy subjects in comparable age served as controls. In venous blood kinetics of spontaneous erythrocyte aggregation and desegregation, as well as erythrocyte deformity were determined.
Results. Increase in blood viscosity, decrease of erythrocyte deformity, acceleration of erythrocyte aggregation and increase in erythrocyte aggregates size were detected. In patients with active lupus nephritis time of erythrocyte aggregation, size and durability of erythrocyte aggregates, erythrocyte deformity were minimal. In active lupus nephritis with high-grade haematuria size of erythrocyte aggregates was maximal.
Conclusion. Haemorheology disturbances in lupus nephritis increase simultaneously with the disease activity.

References

  1. Тареева И.Е., Краснова Т.Н. Поражение почек при системной красной волчанке. И.Е. Тареева (ред.) «Нефрология». Руководство для врачей. М.: Медицина, 2000., 280-291
  2. Booth S., Chohan S., Curran J.C. et al. Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus. Arthritis Rheum. 2007; 57(5): 845-850
  3. Ernst E., Hein A., Meurer M., Ruzicka T. Blood rheology in lupus erythematosus. Ann. Rheum. Dis. 1991; 50(10): 710-712
  4. Reid H.L., de Ceulaer K. Abnormal plasma and serum viscosity in systemic lupus erythematosus (SLE): a Jamaican study. Clin. Hemorheol. Microcirc. 1999; 20(3): 175-180
  5. Rosenson R.S., Shott S., Katz R. Elevated blood viscosity in systemic lupus erythematosus. Semin. Arthritis Rheum. 2001; 31(1): 52-57
  6. Vayá A., Murado J., Santaolaria M. et al. Haemorheological changes in patients with systemic lupus erythematosus do not seem to be related to thrombotic events. Clin. Hemorheol. Microcirc. 2008; 38(1); 23-29
  7. Соколова И.А., Краснова Т.Н., Георгинова О.А. и др. Гемореологические особенности больных с разными клиническими проявлениями системной красной волчанки. Регионарное кровообращение и микроциркуляция. 2008; 7(3): 45-53
  8. Гусева С.А., Вознюк В.П. Болезни системы крови. М.: «Медпресс-информ», - 2004
  9. Fukasawa T., Arai T., Naruse T., Maekawa T. Hyperviscosity syndrome in a patient with systemic lupus erythematosus. Am. J. Med. Sci. 1977; 273(3): 329-334
  10. Schmid-Schönbein H., Rieger H., Gallasch G,. Schachtner H. Pathological red cell aggregation (clump aggregation). Molecular and electrochemical factors. Bibl. Anat. 1977; 16(Pt. 2): 484-489
  11. Cameron J.S. Lupus nephritis. J.Am. Soc. Nephrol. 1999; 10: 413-424.
  12. Rahman P., Gladman D.D., Ibanez D., Urowitz M.B. Significance of isolated hematuria and isolated pyuria in systemic lupus erythematosus. Lupus. 2001; 10(6): 418-423.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download