Features of intrarenal blood flow in patients with chronic obstructive pulmonary disease


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Abstract

Purpose. The evaluation of features of intrarenal blood flow in COPD patients by Doppler ultrasonography; evaluation of the diagnostic value of some of its parameters in relationship with the main clinical and laboratory markers of renal dysfunction. Material and Methods. The study included і98 COPD patients treated in SBHCI RCH № 2 of MHKT, and 28 healthy volunteers. All patients underwent renal ultrasound and dopplerographic examination of renal blood flow at the renal artery orifice, segmental, interlobar and arcuate arteries with the calculation of Pourcelot resistance index (Ri), as well as laboratory testing of renal function: calculation of GRFCKD-EPI, determination of serum CYSTATIN С levels, and urinary excretion of albumin and ß2-MICROGLOBULIN. Results. Correlation relationship between ri and laboratory parameters of renal dysfunction, as well as the frequency of exacerbations and renal vascular resistance was revealed. ri of arcuate artery had the greatest sensitivity and specificity for early diagnosis of nephropathy in patients with COPD. Conclusion. The results of our study allow suggest ri measurement of the renal arteries in patients with COPD as appropriate. This is due to the fact that the resistance of the renal blood flow not only reflects the presence of renal dysfunction at the preclinical stage, but also allows to evaluate the possibility of its progression.

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