Pro-inflammatory cytokines and their participation in the development of cardiovascular calcification in patients with chronic kidney disease

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Abstract

Objective. Evaluation of the participation of pro-inflammatory cytokines in cardiovascular calcification, identification of the relationship with the risk of its development in patients with chronic kidney disease (CKD) receiving renal replacement therapy (RRT).

Material and methods. A one-time examination of 85 CKD patients om program hemodialysis was carried out. The blood interleukin-3 (IL-3), IL-6 levels were determined using ELISA; white blood cell (WBC) shift index, and systemic inflammation risk index according to the Glasgow Prognostic Score (GPS) were calculated. Cardiovascular calcification (CVC) was divided into aortic wall calcification (AWC), heart valves (HVC), any calcification (AWC and/or HVC) or concomitant valvular and aortic calcification (AWC+HVC). Statistical analysis was carried out using the Statistica 12.6.

Results. A significant correlation between the risk of the aorta and heart valve calcification (AWC + HVC) with the IL-3 and IL-6 levels (P<0.05) was established. Increase in IL-3 level (more than 35 pg/ml) led to the most pronounced increase in the risk of concomitant calcification (AWC + HVC). The prognostic value of IL-3 was decreased, while IL-6 persistent in the presence of any component of the calcifications of the aorta and heart valves: AWC or HVC. The effect of WBC shift index on the risk of CVC was detected both in relation to concomitant and isolated calcification (P<0.05). The relationship of the systemic inflammation risk index was established in relation to concomitant calcification (P<0.05).

Conclusion. Determining the pro-inflammatory cytokine levels in CKD has the potential to identify patients at risk for CVC. IL-6, IL-3 are involved in the cytokine regulation of CVC in CKD patients.

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About the authors

Aneta M. Mambetova

Kh. M. Berbekov Kabardino-Balkarian State University

Author for correspondence.
Email: amm-0007@yandex.ru
ORCID iD: 0000-0003-0378-0754

Dr. Sci. (Med.), Professor at the Department of General Medical Training and Medical Rehabilitation

Russian Federation, Nalchik

Madina Kh. Khutueva

Republican Clinical Hospital named after Sh.Sh. Ependiev of the Ministry of Health of the Chechen Republic

Email: babaka95@gmail.com
ORCID iD: 0000-0002-7300-5908

Head of the Department of Anesthesiology and Intensive Care

Russian Federation, Grozny

Irina K. Tkhabisimova

Kh. M. Berbekov Kabardino-Balkarian State University

Email: tkhabisim@icloud.com
ORCID iD: 0000-0003-4065-989X

Cand. Sci. (Med.), Head of the Department of General Medical Training and Medical Rehabilitation

Russian Federation, Nalchik

References

  1. Brück K., Stel V.S., Gambaro G.J., et al. CKD Prevalence Varies across the European General Population. Am. Soc. Nephrol. 2016;27(7):2135–47. doi: 10.1681/ASN.2015050542.
  2. Hill N.R., Fatoba S.T., Oke J.L., et al. Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis PLoSOne. 2016;11(7):e0158765. Doi: 0.1371/journal.pone.0158765.
  3. Мухин Н.А. Нефрология. Национальное руководство. Краткое издание. М., 2018. 608 с. [Mukhin N.A. Nephrology. National leadership. Quick Edition. М., 2018. 608 p. (In Russ.)].
  4. Brandenburg V.M., Verhulst A., Babler A., et al. Brandenburg, V.M. Sclerostin in chronic kidney disease-mineral bone disorder think first before you block it! Nephr. Dial. Transpl. 2019;34(3):408–14. doi: 10.1093/ndt/gfy129.
  5. Ganidagli B., Nacar H., Yildyz Y.S., et al. The relationship between serum osteopontin and FGF-23 levels with valvular calcification in hemodialysis patients. Clin. Nephr. 2019;91(1):9–17. doi: 10.5414/CN109505.
  6. Uhlin F., Fernstrom A., Knopen M.H.J., et al. Long-term follow-up of biomarkers of vascular calcification after switch from traditional hemodialysis to online hemodiafiltration. Scand. J. Clin. Lab. Invest. 2019;18:1–9. doi: 10.1080/00365513.2019.1576218.
  7. Sato M., Hanafusa N., Kawaguchi H., et al. Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients. Kidney Blood Press. Res. 2018;43(3):1023–33. doi: 10.1159/000490824.
  8. Anders H.J., Suarez-Alvarez B., Grigorescu M., et al. The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury. Kidney Int. 2018;93(3):656–69. doi: 10.1016/j.kint.2017.09.022.
  9. Benz K., Hilgers K.F., Daniel C., Amann K. Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation. Int. J. Nephrol. 2018;2018:4310379. doi: 10.5527/wjn.v1.i2.43.
  10. Mutluay R., Konca Değertekin C., Işıktaş Sayılar E., et al. Serum fetuin-A is associated with the components of MIAC (malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease. Turk. J. Med. Sci. 2019;49(1):327–35. doi: 10.3906/sag-1809-43.
  11. Durlacher-Betzer K., Hassan A., Levi R., et al. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int. 2018;94(2):315–25. Doi: https://doi.org/10.1016/j.kint.2018.02.026.
  12. Rops A.L., Jansen E., van der Schaaf A., et al. Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37- deficient mice. Kidney Int. 2018;93:6:1356–66. Doi: https://doi.org/10.1016/j.kint.2018.01.005.
  13. Муркамилов И.Т., Айтбаев К.А., Фомин В.В. и др. Цитокины и артериальная жесткость на ранней стадии хронической болезни почек: взаимосвязь и прогностическая роль. Клиническая нефрология. 2018;4:25–32. [Murkamilov I.T., Aitbaev K.A., Fomin V.V., et al. Cytokines andarterial stiffness at the early stage of chronic kidney disease: therelationship and prognostic role. Clinical Nephrology. 2018;4:25–32 (In Russ.)].
  14. Муркамилов И.Т., Айтбаев К.А., Фомин В.В. и др. Провоспалительные цитокины у больных с хронической болезнью почек в фокусе интерлйкин-6. Архив внутренней медицины. 2019;9(6):428–33. [Murkamilov I.T., Aitbaev K.A., Fomin V.V., et al. Pro-inflammatory cytokines in patients with chronic kidney disease in the focus of interlaykin-6. Arch. Int. Med. 2019;9(6):428–33 (In Russ.)]. doi: 10.20514/2226-6704-2019-9-6-428-433.
  15. Мамбетова А.М., Хутуева М.Х., Тхабисимова И.К., Кегадуев А.Ш. Взаимосвязь факторов системного воспаления и сердечно-сосудистой кальцификации у больных с хронической болезнью почек 5Д стадии. СПб. Нефрология. 2020;24(5):58–63. [Mambetova A.M., Khutueva M.Kh., Thabisimova I.K., Kegaduev A.Sh. The relationship of factors of systemic inflammation and cardiovascular calcification in patients with chronic kidney disease stage 5D. SPb. Nphrol. 2020;24(5):5863.]. Doi.10.36485/1561-6274-2020-24-5-58-63.
  16. Мамбетова А.М., Гатураева Ш.Н., Семенова И.Л., Кегадуев А.Ш. Прогнозирование риска развития острого инфаркта миокарда у больных хронической болезнью почек 5Д-стадии и минерально-костными нарушениями. СПб. Нфрология. 2020;24(5):51–7. [Mambetova A.M., Gaturaeva Sh.N., Semenova I.L., A.Sh. Kegaduev. Prediction of the risk of acute myocardial infarction in patients with chronic kidney disease stage 5D and mineral-bone disorders. SPb. Nеphrol. 2020;24(5):51–7.]. doi: 10.36485/1561-6274-2020-24-5-51-57.
  17. Akchurin O., Akchurin O., Patino E., et al. Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD. Kidney Int. Rep. 2019;4(3):470–83. Doi: https: //doi.org/10.1016/j.ekir.2018.12.006
  18. Henaut L., Massy Z.A. New insights into the key role of interleukin 6 in vascular calcification of chronic kidney disease. Nephrol. Dial. Transplantat. 2018; 33:4:543–48. Doi: https://doi.org/10.1093/ndt/gfx379
  19. Scarpioni R., Obici L. Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage. Clin. Exp. Rheumatol. 2018;36:54–60.

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