Clinical evaluation of uropathogen selection in vivo
- Authors: Berdichevsky V.B.1, Berdichevsky B.A.1, Sapozhenkova E.V.1, Pavlova I.V.2, Gonyaev A.R.3, Boldyrev A.L.4, Korabelnikov M.A.1, Petrov D.I.1, Spirina D.S.1
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Affiliations:
- Tyumen State Medical University
- Medical and Sanitary Unit “Neftyanik”
- Clinical Hospital “Mother and Child”
- Regional Clinical Hospital № 2
- Issue: Vol 15, No 1 (2023)
- Pages: 65-69
- Section: Nephrourology
- URL: https://journals.eco-vector.com/2075-3594/article/view/430432
- DOI: https://doi.org/10.18565/nephrology.2023.1.65-69
- ID: 430432
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Abstract
Background. Unraveling the mechanisms of bacterial gene expression in vivo that induce pathogenic properties when they are in their host will help to identify new applications in the development of antimicrobials.
Objective. Evaluation of the influence of glucose metabolism in the urinary tract (UT) on the implementation of bacteriuria manifestations.
Material and methods. A retrospective laboratory and PET/CT molecular-cellular analysis of glucose metabolism
in the bladder in conjunction with the features of the clinical manifestations of bacteriuria was carried out.
Results. New data on biosynthetic and metabolic processes that induce the ability of bacteria to various manifestations
of their presence in the human MF have been obtained
Conclusion. The selection of pathogenic properties in typical representatives of the urinary tract microbiota, which determine the clinical form of bacteriuria, may be associated with the features of glucose metabolism in the organs of the urinary system, which needs special study and clarification.
Keywords
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About the authors
Vadim B. Berdichevsky
Tyumen State Medical University
Email: urotgmu@mail.ru
Doctor of Medical Sciences, Professor of the Department of Oncology with a Course of Urology
Russian Federation, TyumenBoris A. Berdichevsky
Tyumen State Medical University
Email: urotgmu@mail.ru
Doctor of Medical Sciences, Professor, Professor of the Department of Oncology with a Course in Urology
Russian Federation, TyumenEkaterina V. Sapozhenkova
Tyumen State Medical University
Email: ekaterina_chibulaeva@mail.ru
Candidate of Medical Sciences, Associate Professor of the Department of Normal Physiology
Russian Federation, TyumenIrina V. Pavlova
Medical and Sanitary Unit “Neftyanik”
Email: iraena@mail.ru
Urologist of the Department of Urology
Russian Federation, TyumenArtem R. Gonyaev
Clinical Hospital “Mother and Child”
Email: a.gonyaev25@yandex.ru
Urologist
Russian Federation, TyumenAleksey L. Boldyrev
Regional Clinical Hospital № 2
Email: boldyrev.a.l@yandex.ru
Urologist
Russian Federation, TyumenMikhail A. Korabelnikov
Tyumen State Medical University
Email: urotgmu@mail.ru
Russian Federation, Tyumen
Daniil I. Petrov
Tyumen State Medical University
Author for correspondence.
Email: tgmu@tyumsmu.ru
Student of the Faculty of Medicine
Russian Federation, TyumenDaria S. Spirina
Tyumen State Medical University
Email: tgmu@tyumsmu.ru
Student of the Faculty of Medicine
Russian Federation, TyumenReferences
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