Iga-nephropathy in belarusian cohort. clinical and pathological peculiarities, factors, associated with unfavorable outcome


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Resumo

Aim. define clinical, morphological features, factors associated with unfavorable outcome and kidney survival of IgA-nephropathy (IgAN) in city Minsk, republic Belarus. material and methods. it was multicenter clinical trial of 291 patients (31±ii years old, 65,6% male) with igan and initial proteinuria 1,0 [0,42-i,80] g/day, gfr 85 [65-102] ml/min, arterial hypertension 47,4%. 90% of the patients were treated with ace inhibitors. results. multivariate regression analysis revealed independent predictors of unfavorable outcome: arterial hypertension (HR=2,8; p=0,04), gfr<0 ml/min (HR=6,8; p=0,001), tubular atrophy and interstitial fibrosis (T) 26-50% (HR=3,0; p=0,015), t>50% (HR=6,6; p=0,001). the composite 5-, 10-year survival without dialysis and 50% decreasing gfr were 75,7±4 and 47,2±6,8%, respectively. Conclusion. Igan has an unfavorable course of disease in republic Belarus.

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Sobre autores

Kirill Komissarov

Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology; Belarusian Medical Academy of Postgraduate Education

Email: kirill_ka@tut.by
Cand. Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation 8 Semashko str., Minsk

Olga Krasko

United Institute of Informatics Problems of the National Academy of Science of Belarus

Email: olga.krasko.ok@gmail.com
Cand.Sci. (Engineering), Associate Professor, Leading Researcher at the Bioinformatics Laboratory 6 Surganov str., Minsk

Margarita Dmitrieva

Belarusian State Medical University; City Clinical Pathology Bureau

Email: mvdmitieva@inbox.ru
Cand.Sci. (Med.), Teaching Assistant at the Department of Pathological Anatomy 60 Kizhevatov str., Minsk

Tatyana Letkovskaja

Belarusian State Medical University

Email: taletkovskaya@mail.ru
Associate Professor, Head of the Department of Pathological Anatomy 60 Kizhevatov str., Minsk

Maria Lugovskaya

City Nephrology Center, 4th City Clinical Hospital named after N.E. Savchenka

Email: marielugovskaya@gmail.com
Nephrologist 110 R.Lyuksemburg str., Minsk

Yuliya Kalinovskaya

1st City Clinical Hospital

Email: plyutay@yandex.ru
Nephrologist, Department of Nephrology 64 Independence Avenue, Minsk

Valery Pilotovich

Belarusian Medical Academy of Postgraduate Education

Email: pilotovich@mail.ru
Dr. Sci. (Med.), Professor at the Department of Urology and Nephrology 64 Independence Avenue, Minsk

Bibliografia

  1. Добронравов В.А., Мужецкая Т.О., Лин Д.И. и др. Иммуноглобулин А-нефропатия в российской популяции: клинико-морфологическая презентация и отдаленный прогноз. Нефрология. 2019;23(6):45-
  2. Berthoux F., Mohey H, Laurent B., et al. Predicting the risk for dialysis or death in IgA nephropathy. J. Am. Soc. Nephrol. 2011;22(4):752-61. doi: 10.1681/ASN.2010040355.
  3. Cattran D., Coppo R., Cook H., et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009;76(5):534-45. doi: 10.1038/ki.2009.243.
  4. Coppo R., Troyanov S., Bellur S., et al. Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments. Kidney Int. 2014;86:828-36. doi: 10.1038/ki.2014.63.
  5. DAmico G. Natural history of idiopathic IgA nephropathy: Role of clinical and histological prognostic factors. Am. J. Kidney Dis. 2000;36(2):227-37. doi: 10.1053/ajkd.2000.8966.
  6. Gutierrez E., Zamora I., Ballann J.A., et al. Long-term outcomes of IgA nephropathy presenting with minimal or no proteinuria. J. Am. Soc. Nephrol. 2012;23(10):1753-60. doi: 10.1681/ASN.2012010063.
  7. Imai E., Usui J., Kaneko S., et al. The precise long-term outcomes of adult IgA nephropathy by mail questionnaires: Better renal survival compared to earlier cohort studies. PLoS One. 2020;15(5):e0233186. Doi: 10.1371/ journal.pone.0233186.
  8. Levey A.S., Stevens L.A., Schmid C.H, et al. A new equation to estimate glomerular filtration rate. Ann.Intern. Med. 2009;150(9):604-12. doi: 10.7326/0003-4819-150-9-200905050-00006.
  9. Maixnerova D., Neprasova M., Skibova J., et al. IgA nephropathy in Czech patients--are we able reliably predict the outcome? Kidney Blood Press Res. 2014;39(6):555-62. doi: 10.1159/000368467.
  10. Moriyama T. Clinical and histological features and therapeutic strategies for IgA nephropathy. Clin. Exp. Nephrol. 2019;23(9):1089-99. doi: 10.1007/s10157-019-01735-4.
  11. R Core Team (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R
  12. Zhang H., Barratt J. Is IgA nephropathy the same disease in different parts of project.org/
  13. Schena F., Nistor I. Epidemiology of IgA Nephropathy: A Global Perspective. Semin. Nephrol. 2018;38(5):435-42. doi: 10.1016/j.semnephrol.2018.05.013. the world?Semin. Immunopathol. 2021;43(5):707-15. doi: 10.1007/s00281-021-00884-7.
  14. Trimarchi H., Barratt J., Cattran D., et al. Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int. 2017;91(5): 1014-21. doi: 10.1016/j.kint.2017.02.003.

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