Iga-nephropathy in belarusian cohort. clinical and pathological peculiarities, factors, associated with unfavorable outcome


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Aim. define clinical, morphological features, factors associated with unfavorable outcome and kidney survival of IgA-nephropathy (IgAN) in city Minsk, republic Belarus. material and methods. it was multicenter clinical trial of 291 patients (31±ii years old, 65,6% male) with igan and initial proteinuria 1,0 [0,42-i,80] g/day, gfr 85 [65-102] ml/min, arterial hypertension 47,4%. 90% of the patients were treated with ace inhibitors. results. multivariate regression analysis revealed independent predictors of unfavorable outcome: arterial hypertension (HR=2,8; p=0,04), gfr<0 ml/min (HR=6,8; p=0,001), tubular atrophy and interstitial fibrosis (T) 26-50% (HR=3,0; p=0,015), t>50% (HR=6,6; p=0,001). the composite 5-, 10-year survival without dialysis and 50% decreasing gfr were 75,7±4 and 47,2±6,8%, respectively. Conclusion. Igan has an unfavorable course of disease in republic Belarus.

Full Text

Restricted Access

About the authors

Kirill S. Komissarov

Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology; Belarusian Medical Academy of Postgraduate Education

Email: kirill_ka@tut.by
Cand. Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation 8 Semashko str., Minsk

Olga V. Krasko

United Institute of Informatics Problems of the National Academy of Science of Belarus

Email: olga.krasko.ok@gmail.com
Cand.Sci. (Engineering), Associate Professor, Leading Researcher at the Bioinformatics Laboratory 6 Surganov str., Minsk

Margarita V. Dmitrieva

Belarusian State Medical University; City Clinical Pathology Bureau

Email: mvdmitieva@inbox.ru
Cand.Sci. (Med.), Teaching Assistant at the Department of Pathological Anatomy 60 Kizhevatov str., Minsk

Tatyana A. Letkovskaja

Belarusian State Medical University

Email: taletkovskaya@mail.ru
Associate Professor, Head of the Department of Pathological Anatomy 60 Kizhevatov str., Minsk

Maria A. Lugovskaya

City Nephrology Center, 4th City Clinical Hospital named after N.E. Savchenka

Email: marielugovskaya@gmail.com
Nephrologist 110 R.Lyuksemburg str., Minsk

Yuliya I. Kalinovskaya

1st City Clinical Hospital

Email: plyutay@yandex.ru
Nephrologist, Department of Nephrology 64 Independence Avenue, Minsk

Valery S. Pilotovich

Belarusian Medical Academy of Postgraduate Education

Email: pilotovich@mail.ru
Dr. Sci. (Med.), Professor at the Department of Urology and Nephrology 64 Independence Avenue, Minsk

References

  1. Добронравов В.А., Мужецкая Т.О., Лин Д.И. и др. Иммуноглобулин А-нефропатия в российской популяции: клинико-морфологическая презентация и отдаленный прогноз. Нефрология. 2019;23(6):45-
  2. Berthoux F., Mohey H, Laurent B., et al. Predicting the risk for dialysis or death in IgA nephropathy. J. Am. Soc. Nephrol. 2011;22(4):752-61. doi: 10.1681/ASN.2010040355.
  3. Cattran D., Coppo R., Cook H., et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009;76(5):534-45. doi: 10.1038/ki.2009.243.
  4. Coppo R., Troyanov S., Bellur S., et al. Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments. Kidney Int. 2014;86:828-36. doi: 10.1038/ki.2014.63.
  5. DAmico G. Natural history of idiopathic IgA nephropathy: Role of clinical and histological prognostic factors. Am. J. Kidney Dis. 2000;36(2):227-37. doi: 10.1053/ajkd.2000.8966.
  6. Gutierrez E., Zamora I., Ballann J.A., et al. Long-term outcomes of IgA nephropathy presenting with minimal or no proteinuria. J. Am. Soc. Nephrol. 2012;23(10):1753-60. doi: 10.1681/ASN.2012010063.
  7. Imai E., Usui J., Kaneko S., et al. The precise long-term outcomes of adult IgA nephropathy by mail questionnaires: Better renal survival compared to earlier cohort studies. PLoS One. 2020;15(5):e0233186. Doi: 10.1371/ journal.pone.0233186.
  8. Levey A.S., Stevens L.A., Schmid C.H, et al. A new equation to estimate glomerular filtration rate. Ann.Intern. Med. 2009;150(9):604-12. doi: 10.7326/0003-4819-150-9-200905050-00006.
  9. Maixnerova D., Neprasova M., Skibova J., et al. IgA nephropathy in Czech patients--are we able reliably predict the outcome? Kidney Blood Press Res. 2014;39(6):555-62. doi: 10.1159/000368467.
  10. Moriyama T. Clinical and histological features and therapeutic strategies for IgA nephropathy. Clin. Exp. Nephrol. 2019;23(9):1089-99. doi: 10.1007/s10157-019-01735-4.
  11. R Core Team (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R
  12. Zhang H., Barratt J. Is IgA nephropathy the same disease in different parts of project.org/
  13. Schena F., Nistor I. Epidemiology of IgA Nephropathy: A Global Perspective. Semin. Nephrol. 2018;38(5):435-42. doi: 10.1016/j.semnephrol.2018.05.013. the world?Semin. Immunopathol. 2021;43(5):707-15. doi: 10.1007/s00281-021-00884-7.
  14. Trimarchi H., Barratt J., Cattran D., et al. Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int. 2017;91(5): 1014-21. doi: 10.1016/j.kint.2017.02.003.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies