Vol 2, No 3 (2014)

The development of medical compositions with herbal drug raw materials is an urgent issue of today. The production technology offered considers the use of domestic raw materials and maximal extraction of accessory agents from them, i.e. low-waste method. The purpose of this research is a selection of the best possible carrier base for soft external dosage form with Rhaponticum carthamoides extract. Traditional equipment for soft dosage forms processing was used during this study. Organoleptic properties of ointments, their pharmacological availability were examined, and production cost components were taken into account. Hence the studies conducted an optimal carrier base for production of external drug dosage with Rhaponticum carthamoides extract was chosen.

The article is devoted to a problem of rational medicines supply for military medical institutions. The main theoretical positions of the formulars system, pharmacoeconomical analysis and standardization as important instruments of medicines use optimization in military hospitals are elaborated and generalized.

Morphological and anatomical features of thalluses of brown (Laminaria saccharina, Fucus vesiculosus) and red (Ahnfeltia plicata) algae, procured at a coastal strip of the Northern basin in gulfs of Ura-Guba and Palkina-Guba at different depths. Compliance of Fucus and Ahnfeltia with pharmacopoeial norms and merchandising indices for Laminaria was established, except for high concentration of sand in Ahnfeltia thalluses. The identity of algae between each other was shown based on the results of qualitative analysis on polysaccharides, alginic acids, reducing sugars, iodine, mannitol, amino acids presence. Quantitative content of polysaccharides, alginic acids, reducing sugars, pentosans, iodine, cellulose, mannitol, proteins, lipids, agar was determined. In comparison with Fucus and Ahnfeltia higher concentration of the following content was noted in Laminaria: alginic acids (1.4 and 5.75 times higher), polysaccharides (1.3 and 1.4 times), iodine (4.5 and 1.8 times), mannatol (1.5 and 2.5 times) (data received is statistically reliable). Impropriety of storm algae for processing was shown as law quality raw material. The highest concentration of active substances was revealed in Laminaria thalluses which were procured at the depth of 10 m in a period from September to October. Active accumulation of sodium, potassium, calcium, iron, magnesium, manganese corresponding to similar sea water composition was established in algae. Mathematical equations of regression between protein and manganese, protein and iron content in algae were deduced. Under proper conditions of drying and storage high quality of the materials can be preserved during 3 years. Based on the findings of photochemical researches, taking into account squares of plantations and possible exploitation stocks, the possibility and prospectivity of industrial processing of Fucus vesiculosus and Ahnfeltia plicata together with Laminaria saccharina as plant sources of polysaccharides (mainly alginates) was proved.

Morphological and anatomical study of Ziziphora puschkinii Adams. was carried out. It resulted on the revelation of diagnostic signs of a stem, leafstalk and lamina structure. According to the present results, the nodal and caulifoliar morphology in Ziziphora may be helpful in systematic researches. Stomatal apparatus of diacytic type and big unicellular trichomes presence may be considered to be diagnostic signs of lamina epidermis. The data reseived may be uded in further systematic researches of Ziziphora L. genus.