Mediators of immune responses in cerebrospinal fluid with viral infections of central nervous system



Cite item

Full Text

Abstract

The revue includes contemporary information about the immune factors in cerebrospinal fluid (CSF) of patients with viral infections of central nervous system (CNS). The CSF concentrations of immunoglobulins, complement components, virus-specific antibodies, and inflammation mediators reflect their pathogenetic role in infection, that allows to use these parameters for dyagnostic improvement, course of disease prognosis, and in therapy monitoring. Detection in CSF of cytokines and chemokines, that are reflecting peculiarities of system and local immune responses in infection course, is especially clinically significant.

Full Text

Restricted Access

About the authors

G F Zheleznikova

Research Institute of Children Infections of the Federal Medico-Biological Agency of Russia, St. Petersburg

Email: zheleznikova.galina@gmail.com

N V Skripchenko

Research Institute of Children Infections of the Federal Medico-Biological Agency of Russia, St. Petersburg

Y V Lobzin

Research Institute of Children Infections of the Federal Medico-Biological Agency of Russia, St. Petersburg

References

  1. Железникова Г.Ф. Роль гамма-интерферона в иммунопатогенезе инфекций // Клин. лаб. диагн. 2008. № 4. С. 3-8.
  2. Железникова Г.Ф. Цитокины как предикторы течения и исхода инфекций // Цитокины и воспаление. 2009. Т. 8. № I.C. 10-17.
  3. Железникова Г.Ф., Скрипченко Н.В. Иммунопатогенез инфекционно-воспалительных заболеваний центральной нервной системы // Инфектология. 2011. Т. 3. № 2. С. 28-32.
  4. Кетлинский С.А., Симбирцев A.C. Цитокины. СПб.: Фолиант, 2008.
  5. Моргацкий Н.В., Железникова Г.Ф., Скрипченко Н.В. Иммунопатогенетические особенности клещевого энцефалита у детей и новые подходы к терапии // Мед. иммунол. 2007. Т. 9. № 2-3. С. 235- 236.
  6. Сорокина М.H., Скрипченко Н.В. Вирусные энцефалиты и менингиты у детей: Руководство для врачей. М.: Медицина, 2004.
  7. Abdulle S., Mellgren A., Brew В. et al. CSF neurofilament protein (NFL) - a marker of active HIV-related neurodegeneration // J. Neurol. 2007. Vol. 254. № 8. P. 1026-1032.
  8. Anthony I., Crawford D., Bell J. Effects of human immunodeficiency virus encephalitis and drug abuse on the В lymphocyte population of the brain // J. Neuroimmunol. 2004. Vol. 10. № 3. P. 181-188.
  9. Attallah A., Ibrahim G. Immunodetection of a hepatitis С virus (HCV) antigen and Thl/Th2 cytokines in cerebrospinal fluid of meningitis patients // J. Immunoassay Immunochem. 2004. Vol. 25. № 4. P. 313-320.
  10. Christo P., Viela Mde C., Bretas T. et al. Cerebrospinal fluid levels of chemokines in HIV infected patients with and without opportunistic infection of the cen tral nervous system // J. Neurol. Sei. 2009. Vol. 287. № 1-2. P. 79-83.
  11. Denes E., Labach C., Durox H. et al. Intrathecal synthesis of specific antibodies as a marker of herpes simplex encephalitis in patients with negative PCR // Swiss Med. Wkly. 2010. Vol. 140. w13107.
  12. Gisslen M., Lekman A., Fredman P. Cerebrospinal fluid antibodies directed against neuron-associated gangliosides in HIV-1 infection // Infection. 2000. Vol. 28. № 3. P. 143-148.
  13. Grygorczuk S., Zajkowska J., Swierzbinska R. et al. Concentration of beta-chemokine CCL5 (RANTES) in cerebrospinal fluid in patients with tick-borne encephalitis // Neurol. Neurochir. Pol. 2006. Vol. 40. № 2. P. 106-111.
  14. Grygorczuk S., Zajkowska J., Swierzbinska R. et al. Elevated concentration of the chemokine CCL3 (МІР-1α) in cerebrospinal fluid and serum of patients with tick borne encephalitis //Adv. Med. Sei. 2006. Vol. 51. P. 340-344.
  15. Haspolat S., Anlar B., Köse G. et al. Interleukin-1β, interleukin-1 antagonist levels in patients with subacute sclerosing panencephalitis and the effects of different treatment protokols //. Child. Neurol. 2001. Vol. 16. N6. P. 417-420.
  16. Holub M., Beran O., Lacinová Z. et al. Interferon-gamma and cortisol levels in cerebrospinal fluid and its relationship to the etiology of aseptic meningoencephalitis // Prague Med. Rep. 2006. Vol. 107. № 3. P. 343-353.
  17. Ichiyama T., Shoji H., Takahashi Y. et al. Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis // Cytokine. 2008. Vol. 44. № 1. P. 149-153.
  18. Ichiyama T., Ito Y., Kubota M. et al. Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection // Brain Dev. 2009. Vol. 31. № 10. P. 731-738.
  19. Jongen P., Doesburg W., Ibrahim-Stappers J. et al. Cerebrospinal fluid C3 and C4 indexes in immunological disorders of the central nervous system // Acta Neurol. Scand. 2000. Vol. 101. №2. P. 116-121.
  20. Kawashima H., loi H., Ishii С. et al. Viral loads of cerebrospinal fluid in infants with enterovirus meningitis // J. Clin. Lab. Anal. 2008. Vol. 22. № 3. P. 216-219.
  21. Kawashima H., Suzuki K., Yamanaka G. et al. Antiglutamate receptor antibodies in pediatric enteroviral encephalitis // Int. J. Neurosci. 2010. Vol. 120. № 2. P. 99-103.
  22. Lackner P., Guengoer E., Beer R. et al. IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases // BMC Infect. Dis. 2010. Vol. 10. P. 202.
  23. Lentz M., Degaonkar M., Mohamed M. et al. Exploring the relationship of macrophage colony-stimulating factor levels on neuroaxonal metabolism and cognition during chronic human immunodeficiency vitus infection // J. Neurovirol. 2010. Vol. 16. № 5. P. 368-376.
  24. Lepej S., Misic-Majerus L., Jeren T. et al. Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis // Acta Neurol. Scand. 2007. Vol. 115. № 2. P. 109-114.
  25. Lucas S., Rothwell N., Gibson R. The role of inflammation in CNS injury and disease // Br. J. Pharmacol. 2006. Vol. 147 (Suppl. 1 ). P. 232-240.
  26. Michalowska-Wender G., Losy J., Kondrusik M. et al. Evaluation of soluble platelet cell adhesion molecule sPECAM-1 and chemokine MCP-1(CCL2) concentration in CSF of patients with tick-borne encephalitis // Pol. Merkur. Lekarski. 2006. Vol. 20. № 115. P. 46-48.
  27. Mistchenko A., Fomari M., Viegas M. et al. Detection of interleukin-10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis // J. Neurovirol. 2005. Vol. 11. № 1. P. 66-69.
  28. Mustonen K., Uotila L., Laitinen R., Koskiniemi M. CSF findings in neonates with seizures; infectious and noninfectious // J. Perinat. Med. 2003. Vol. 31. № 1. P. 69-74.
  29. Nagafuchi M., Nagafuchi Y., Sato R. et al. Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fluid cytokines // Intern. Med. 2006. Vol. 45. №21. P. 1209-1212.
  30. Nolting T., Lindecke A., Koutsilieri E. et al. Measurement of soluble inflammatory mediators in cerebrospinal fluid of human immunodeficiency virus-positive patients at distinct stages of infection by solid-phase protein array // J. Neurovirol. 2009. Vol. 15. № 5-6. P. 390-400.
  31. Puccioni-Sohler M., Soares C., Papaiz-Alvarenga R. et al. Neurologic dengue manifestations associated with intrathecal specific immune response // Neurology. 2009. Vol. 73. № 17. P. 1413-1417.
  32. Sanchez-Ramon S., Bellón J., Resino S. et al. Low blood CD8+ T-lymphocytes and circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children // Pediatrics. 2003. Vol. 111. № 2. P. 168-175.
  33. Suh H., Brosnan C., Lee S. Toll-like receptors in CNS viral infections // Curr. Top. Microbiol. Immunol. 2009. Vol. 336. P. 63-81.
  34. Tatomirović Z., Bokun R., Bokonjić D. Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome // Vojnosanit. Pregl. 2002. Vol. 59. № 3. P. 265-270.
  35. Winter P., Dung N., Loan H. et al. Proinflammatory cytokines and chemokines in humans with Japanese encephalitis // J. Infect. Dis. 2004. Vol. 190. № 9. P. 1618-1626.
  36. Yilmaz D., Yüksel D., Senbil N. et al. Cerebrospinal fluid nitric oxide levels in subacute sclerosing panencephalitis // Pediatr. Neurol. 2009. Vol. 41. N 3. P. 179-182.
  37. Zajkowska J., Grygorczuk S., Pryszmont J. et al. Concentration of interleukin 6 and 10 in tick-borne and purulend encephalomeningitis // Pol. Merkur. Lekarski. 2006. Vol. 21. № 121. P. 29-34.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Zheleznikova G.F., Skripchenko N.V., Lobzin Y.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies