Production of sFas, sFasL, TRAIL by placental tissue during normal pregnancies and those complicated by gestosis

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Surface molecules secretory variants can appear in different biological liquids because of various physiological and pathological processes. The aim of this investigation was comparison of sFas, sFasL, TRAIL serum concentrations and their placental production for different development terms in normal pregnancies and those complicated by gestosis. We observed that sFas concentrations in collected after placental tissue incubation supernatants in 3th trimester placentas and 1th trimester one were equal. Secretion of sFasL was decreased and secretion ofTRAIL was increased in terminal gestation age in comparison with early pregnancy. sFas placental tissue secretion was increased and sFasL secretion was lightly increased in complicated by gestosis pregnancies in comparison with normal one. TRAIL placental tissue secretion was equal in normal pregnancies and those complicated by gestosis. Serum sFas and sFasL were detected in neither normal pregnancies group, nor in those complicated by gestosis. Variation of sFas, sFasL and TRAIL placental tissue secretion during normal placental development reflects placental structures formation and stabilization. Compensatory protection mechanisms against abundant angiogenic and apoptotic stimulus and maternal lymphocytes cytotoxic affects are initiated in placental tissue during gestosis.

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  1. Abrahams V.M., Straszewski-Chavez S.L., Guller S. et al. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis // Mol. Hum. Rc- prod. 2004. Vol. 10. P. 55-63.
  2. Aggarwal В.В. Signalling pathways of the TNF superfamily: double-edged sword //Nat. Rev. Immunol. 2003. Vol. 3. P. 745-756.
  3. Allaire A.D., Ballenger K.A., Wells S.R. et al. Placental apoptosis in preeclampsia // Obstet. Gynecol. 2000. Vol. 96. P. 271-276.
  4. Ashton S.V., Whitley G.S., Dash P.R. et al. Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions // Arterioscler. Thromb. Vase. Biol. 2005. Vol. 25. P. 102-108.
  5. Brown S.B., Savill J. Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes // J. Immunol. 1999. Vol. 162. P. 4S0-485.
  6. Calucci L., Pinzino C., Zandomeneghi M. et al. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs and spices // J. Ag- ric. Food. Chem. 2003. Vol. 12. № 4. P. 927-934.
  7. Cheng J., Zhou T., Liu C. et al. Protection from Fas- mediated apoptosis by soluble form of the Fas molecule // Science. 1994. Vol. 263. P. 1759-1762.
  8. Ehrhardt F.I., Fulda S., Schmid I. et al. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kB // Oncogene. 2003. Vol. 22. P. 3842-3852.
  9. Hammer A., Blaschitz A., Daxbock C. et al. Fas and Fas-ligand are expressed in the uteroplacental unit of firsttrimester pregnancy // Am. J. Reprod. Immunol. 1999. Vol. 41. P. 41-51.
  10. Ishihara N., Matsuo H., Murakoshi H. et al. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauter- inegrowth retardation //Am. J. Obstet. Gynecol. 2002. Vol. 186. P. 158-166.
  11. Itoh N., Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen // Biol. Chem. 1993. Vol. 268. P. 10932-10937.
  12. Jiang S.P., Vacchio M.S. Multiple mechanisms of peripheral T cell tolerance to the fetal allograft // J. Immunol. 1998. Vol. 160. P. 3086-3090.
  13. Kauma S.W., Huff T.F., Hayes al. Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus // J. Clin. Endocrinol. Metab. 1999. Vol. 84. P.2188-2194.
  14. Kim S., Ryu H., Yang J. et al. Maternal serum levels of VCAM-1, ICAM-1 and E-selectin in preeclampsia // J. Korean Med. Sci. 2004. Vol. 19. P. 688-692.
  15. Krauss T., Kuhn W., Lakoma C. et al. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia // Obstet. Gynecol. 1997. Vol. 177. № 2. P. 443-449.
  16. Mor G., Abrahams V.M. Potential role of macrophages as immunoregulators of pregnancy // Reprod. Biol. Endocrinol. 2003. Vol. 1. P. 119-120.
  17. Mor G., Gutierrez L.S., Eliza M. et al. Fas-fas ligand system-induced apoptosis in human placenta and gestational trophoblastic disease // Am. J. Reprod. Immunol. 1998. Vol. 40. P. 89-94.
  18. Pimentel-Muinos F.X., Seed B. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation // Immunity. 1999. Vol. 11. P. 783-793.
  19. Phillips T.A., Ni J., Pan G. et al. TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilegel // J. Immunol. 1999. Vol. 162. P. 6053-6059.
  20. Phocas I., Rizos D., Papoulias J. et al. A comparative study of serum soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-1 in preeclampsia // J. Perinatol. 2000. Vol. 20. P. 114-119.
  21. Sheridan J.P., Marsters S.A., Pitti R.M. et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors // Science. 1997. Vol. 277. P. 818.
  22. Siegel R.M., Frederiksen J.K., Zacharias D.A. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations // Science. 2000. Vol. 288. P. 2354-2357.
  23. Tafuri A., Alferink J., Moller P. et al. T cell awareness of paternal alloantigens during pregnancy // Science. 1995. Vol. 270. P.630-633.
  24. Uckan D., Steele A., Cherry A. et al. Trophoblasts express Fas ligand: proposed mechanism for immune privilege in placenta and maternal invasion // Mol. Hum. Reprod. 1997. Vol. 3. P. 655-662.
  25. Zamai L. Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligandby immature and mature primary human NK cells // J. Exp. Med. 1998. Vol. 188. № 12. P. 2375-2380.



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Copyright (c) 2010 Stepanova O.I., Lesnichija M.V., Klukina M.A., Arzhanova O.N., Selkov S.A., Sokolov D.I.

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